Searchable abstracts of presentations at key conferences in endocrinology

ea0016p478 | Neuroendocrinology | ECE2008

Cyclical Cushing's syndrome: prevalence in patients with Cushing's disease

Alexandraki Krystallenia I , Kaltsas Gregory A , Isidori Andrea M , Akker Scott A , Drake William M , Chew Shern L , Monson John P , Besser G Michael , Grossman Ashley B

Background: Cyclical Cushing’s syndrome has been considered to be a rare clinical entity, characterised by periodic increases in cortisol levels followed by regression of the Cushing’s syndrome. The cycles of hypercortisolism may occur before the establishment of the diagnosis, rendering actual diagnosis difficult, or may occur after inadequate or ineffective treatment and affect disease management. The aim of this study was to investigate the prevalence of cyclicity...

ea0056p1160 | Thyroid cancer | ECE2018

Treatment strategies in medullary thyroid carcinoma – outcome following initial surgery with a curative, debulking or prophylactic intent

Mitravela Vasiliki-Ioanna , Glynn Nigel , Waterhouse Mona , Akker Scott , Korbonits Marta , Drake William , Berney Daniel , Plowman Nick , Carpenter Robert , Parvanta Laila , Druce Maralyn

Medullary thyroid carcinoma (MTC) is a rare malignancy which has often metastasised at time of diagnosis. Surgical resection represents the only prospect for cure. However, debulking neck surgery may be beneficial in advanced cases. Prophylactic surgery is increasingly undertaken in asymptomatic patients with known mutations in the RET oncogene. The aim was to describe the outcome following initial surgical treatment for MTC at our institution. We performed a retrospe...

ea0077p10 | Adrenal and Cardiovascular | SFEBES2021

Method of venesection and location of peripheral sample alter adrenal venous sampling results and interpretation in primary aldosteronism

Mourougavelou Vishnou , Wu Xilin , Goodchild Emily , Argentesi Giulia , Laycock Kate , Akker Scott , Druce Maralyn , Sze Candy , Waterhouse Mona , Dawnay Anne , Matson Matthew , Brown Morris , Drake William , O’Toole Sam

Introduction: Adrenal venous sampling (AVS) is the criterion standard method of lateralisation in primary aldosteronism (PA). Despite this pivotal role, there is limited consensus and significant variability between centres related to many of the technical aspects of AVS. In this study, we sought to address whether variations in two different technical aspects of AVS altered parameters and interpretation, namely: 1. Peripheral sample site 2. Method of adrenal vein (AV) venesec...

ea0051oc5.1 | Oral Communications 5 | BSPED2017

New insights into the preoperative localisation of corticotroph adenomas in paediatric Cushing’s disease (CD)

Wilkinson Ingrid C.E. , Evanson Jane , Matson Matthew , Miszkiel Katherine , Grieve Joan , Sabin Ian , Afshar Farhad , Martin Lee , Grossman Ashley B. , Akker Scott , Savage Martin O. , Drake William M. , Storr Helen L.

Introduction: Selective transsphenoidal microadenomectomy (TSS) is the first-line treatment of paediatric Cushing’s disease (CD). Corticotroph adenomas in children are often small and difficult to visualize. We aimed to assess the utility of pituitary MRI and bilateral inferior petrosal sinus sampling (BIPSS) in confirming the diagnosis of CD and the localisation of the adenoma. We also report our early experience of STEALTH MRI (volumetric T1 weighted, contrast-enhanced ...

ea0070aep600 | Pituitary and Neuroendocrinology | ECE2020

Phenotypic differences between patients with familial pituitary neuroendocrine tumours due to MEN1 or AIP mutations

Marques Pedro , Magalhães Daniela , Caimari Francisca , Hernández Ramírez Laura , Collier David , Lim Chung , Stals Karen , Ellard Sian , Druce Maralyn , Akker Scott , Waterhouse Mona , Drake William , Grossman Ashley B. , Korbonits Marta

Introduction: Germline AIP and MEN1 mutations are the main known aetiologies of familial pituitary neuroendocrine tumours (PitNETs), which represent 5% of all PitNETs. We compared the clinical and tumour characteristics of AIP (AIP mut) and MEN1 mutation-positive (MEN1 mut) PitNET patients.Methods: We retrospectively analysed 70 MEN1 mut and 167 AIP mut patients with PitNETs. MEN...

ea0028p251 | Pituitary | SFEBES2012

The characterisation of growth hormone-related cardiac disease with magnetic resonance imaging

Thomas Julia , Dattani Abhishek , Burchell Thomas , Zemrak Filip , Khoo Bernard , Chew Shern , Kaplan Felicity , Drake William , Aylwin Simon , Gurnell Mark , Akker Scott , Petersen Steffen , Davies Ceri , Grossman Ashley , Korbonits Marta

Acromegaly causes a distinct cardiomyopathy. Growth hormone deficiency (GHD) limits cardiac response to exercise and increases cardiac mortality. Cardiac magnetic resonance imaging (CMR) is considered the gold standard for assessment of cardiac mass and provides data on function, fibrosis, valves and ischaemia. Twenty-three patients with abnormal GH levels (acromegaly, n=13; adult-onset GHD, n=10) and 23 matched controls underwent CMR. Patients had repeat CMR at ...

ea0021oc2.8 | Neuroendocrine tumours/pituitary | SFEBES2009

Diagnosis and localisation of insulinoma: the value of modern MRI in conjunction with calcium stimulation catheterisation

Muthuppalaniappan Vasantha M , Druce Maralyn R , O'Leary Benjamin , Chew Shern L , Drake William M , Monson John P , Akker Scott A , Besser Michael , Sahdev Anju , Rockall Andrea , Vyas Soumil , Matson Matthew , Berney Daniel , Bhattacharya Satya , Grossman Ashley B

Objective: To review the diagnostic features and localization accuracy of different investigations for insulinomas diagnosed 1990–2009 at a single tertiary referral centre.Design: A cross-sectional, restrospective analysis, including sporadic tumours and those in multiple endocrine neoplasia syndromes.Methods: Case notes and investigation results were reviewed from patients with biochemically or histologically-proven insulinom...

ea0073aep842 | Late Breaking | ECE2021

The first comprehensive study of the clinical response of a cohort of acromegalic patients with somatostatin responsive headache

Sonia Kaniuka-Jakubowska , J Levy Miles , Pal Aparna , Abeyaratne Dayakshi , Drake William , Kyriakakis Nikolaos , D Murray Robert , M Orme Steve , Gohil Shailesh , Brook Antonia , Leese Graham , Márta Korbonits , Wass John

It is known that acromegaly may be associated with headache as a significant co-morbidity. Amongst all acromegaly headache patients, there is a unique group with specific types of severe headache that fail to improve despite acromegaly therapy and are resistant to conventional analgesics, however, immediately respond to subcutaneous short-acting (SA) somatostatin analogue (SSA) treatment. We have surveyed 8 tertiary specialist UK centres and identified 18 patients (6 females) ...

ea0086oc2.4 | Endocrine Cancer and Late Effects | SFEBES2022

Delta-like non-canonical Notch ligand 1 (DLK1) – a novel biomarker in adrenocortical carcinoma

Pittaway James , Mariniello Katia , Altieri Barbara , Sbiera Iuliu , Sbiera Silviu , Chung Teng-Teng , Abdel-Azziz Tarek , DiMarco Aimee , Palazzo Fausto , Akker Scott A. , Landwehr Laura-Sophie , Ronchi Cristina , Parvanta Laila , Drake William , Kroiss Matthias , Fassnacht Martin , Guasti Leonardo

Adrenocortical carcinoma (ACC) is a rare malignancy with limited treatment options and a heterogenous prognosis. The histological diagnosis of ACC is complex and there is increasing interest in identifying and validating new immunohistochemical markers. Delta-like non-canonical Notch ligand 1 (DLK1) is a cleavable single-pass transmembrane protein. In humans, DLK1 is present in many tissues during foetal development, is restricted to progenitor/stem cells in a few adult tissue...

ea0086p7 | Adrenal and Cardiovascular | SFEBES2022

Adrenalectomy for unilateral primary aldosteronism improves quality of life: prospective analyses in the MATCH trial

Blackstone Brittany , Goodchild Emily , Tooze Oliver , Salsbury Jackie , Wu Xilin , Ronaldson Amy , Senanayake Russell , Bashari Waiel , Argentesi Giulia , O'Toole Samuel M. , Parvanta Laila , Sahdev Anju , Laycock Kate , Cruickshank Kennedy , Gurnell Mark , M. Drake William , Brown Morris J.

Background: After adrenalectomy (ADX) for primary aldosteronism (PA), approximately 30% of patients achieve clinical success (normalisation of home BP); many additional patients report feeling subjectively better. We used the non-randomised MATCH study1 to further assess quality of life (QoL) changes in participants.Objective: Assess QoL using the 36-item Short Form Health Survey (SF-36) after surgical treatment of unilateral PA and medical treatment of ...