Endocrine Abstracts

Introduction: Hashimoto’s thyroiditis (HT) is multifactorial disease. Interaction between cellular and humoral immunity is base of HT’s pathogenesis. HT’s assessment is difficult because the prevalence of patient with an increased titer of thyroid’s autoantibody and normal thyroid’s function is high. Our research focuses on the estimating of the prevalence of HT in certain regions of the Russian Federation (Tula Region and Chechen Republic), and estima...

Aim: To identify associations of polymorphisms in TLR9, IL28B, TLR2 with autoimmune adrenal insufficiency (AAI).Methods: In n = 54 patients with AAI (isolated and as part of type 2 autoimmune polyglandular syndrome (APS-2; group 1a)), n = 9 patients with APS-1 (group 1b), n = 32 healthy individuals (group 2) we analyzed polymorphisms in IL28B (rs12979860, rs8099917), TLR9 (rs5743836, rs352140), TL...

Background: Acromegaly is a chronic endocrine disease characterized by excessive secretion of somatotropic hormone (GH), which in turn leads to increased secretion of insulin-like growth factor 1 (IGF-1) in the liver. Many cells in the body are targets for these hormones. Excess of GH, in the vast majority of cases caused by hormone-producing pituitary adenoma, and IGF-1 leads to cellular and tissue growth of practically all organs and systems, including the bone and joint app...