Endocrine Abstracts

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W F Young Jr, Mayo Clinic, Rochester, Minnesota, USA AbstractProf. William Young is Professor of Medicine at the Mayo Clinic College of Medicine and Vice-Chair of the Division of Endocrinology, Diabetes, Metabolism, and Nutrition. He received his MD degree from Michigan State University. Prof. Young trained in endocrinology and metabolism at Mayo Clinic, Rochester, Minnesota. He has been a member of the staff at Mayo ...

In the prevalence of obesity has increased worldwide reaching 30% of the adult population in some countries. Direct and inferential evidences show that this excess of body fat is associated with adverse health consequences, and that even a modest 5 to 10% weight loss results in substantial improvement in health. Considering the limited efficacy of the so-called ‘life style’ interventions based on diet plus exercise in the obese subjects, and that bariatric surgery is...

The Short Stature Homeobox-containing gene, SHOX, encodes a transcription factor involved in regulation of growth. SHOX haploinsufficient patients including those with Turner syndrome (TS) show growth impairment with or without mesomelic skeletal dysplasia. This study assessed the efficacy of GH in treating short stature associated with SHOX deficiency (SHOX-D). Prepubertal short patients (24 males, 28 females; 3.0–12.3 years) with molecularly-proven SHOX-D were ra...

Hypocalcemic cardiomyopathy due to hypoparathyroidism is a very rare condition which responds favorably to vitaminocalcic treatment.We report the case of a 50 years old man who presented to our unit for general fatigue, apathy and cough lasting several years with a worsening during the last months, there was biological evidence of hypoparathyroidism with profound hypocalcemia (21 mg/l) hyperphosphoremia (53 mg/l) and undetectable PTH levels the CT scan s...

A 60-year-old Caucasian male was referred to our Endocrine unit with symptoms suggestive of adrenal failure (malaise and fatigue).A Synachten test confirmed the diagnosis (baseline cortisol <5 nmol/l, post Synachten 74 nmol/l) and indicated secondary adrenal failure (baseline ACTH undetectable). Further hormonal tests showed secondary hypothyroidism (TSH 0.43 mU/ml, FT4 7.1 pmol/l) and hypogonadism (testosterone <0.7 nmol/l, LH 0.6 U/l). Prolacti...

Anorexia nervosa (AN) is a psychiatric disorder featuring multiple endocrine abnormalities, comprising a decrease in IGF-I production and an increase in GH concentrations. This resistance to GH action may contribute to impaired haematopoiesis in AN as GH/IGF-I modulate blood cell proliferation and GH therapy exerts beneficial effects on hematocrit values in GH deficient patients. Aim of the present study is to evaluate the link between GH/IGF-I status and haematologic p...

Introduction: The type of Maternal electrolyte taken during prenatal period may change the homeostasis of body fluids which genetically sensitizes individuals during maturation. So in this experience, we studied the effects of different Nacl concentrations in distilled water used by pregnant rats on their offspring.Method: Eight groups, each containing 6 Mature rats with 200 gr weight were selected, Each group contain 5 non pregnant rats and a male durin...

Introduction: Despite early demonstrations that sympathetic activation elevates blood pressure and early clinical inklings that human hypertension may have a psychosomatic component, the pivotal role of the nervous system in human hypertension is only recently being clarified. We studied the effect of nutrition with different salt concentrations on autonomic nervous response.Method: Eight groups of rats, six in each group, (one male and five female) havi...

Introduction: The tendency to eat salty foods is an individualized matter. Aldosterone plays an important role in this increase in salt appetite. In this study the effects of different salt concentrations during pregnancy on Na and aldosterone level, adrenal gland and salt appetite of rat’s infants and the relation of salt consumption with Bp were studied.Method: Eight groups of rats, six rats in each group, (ones of male and five female) having 200...