Endocrine Abstracts

Introduction: Salt in the principal supply of sodium. In normal conditions the average daily salt intake of Iranian adults is 5–15 gr. 4–6 spoonfuls of salt in a day can be lethal, but for soldiers in equatorial regions 50 grams of salt in a day may be needed. In this study the effects of salt on night sleep was addressed.Method: 20 volunteer students were chosen for the study. They had no problem sleeping before the study. They recorded the ti...

Introduction: Thirst and ADH secretion are two principle mechanisms for controlling body fluid osmolarity. Even an excessive load of salt can effectively be handled by these systems. We studied the effect of salt solution consumption on serum sodium level and osmolarity and the action of these two systems.Method: Seven groups each consisting of 6 male rats weighing 200±20 gr. were chosen. Salt solutions (1,3,5, 7 and 9%) were also provided. The rats...

Galactorrhea (G) is a frequent symptom in endocrinology when breast are systematically examined. In literature there is few works about aetiologies of G. The aim of our work is to evaluate prevalence of G and to study it’s cause in 170 subjects with nipple discharge.Our methodology is based on anamnestic history, clinical exam and a complete hormonal exploration. Women with normal cycle has a temperature curve, endometrial biopsy and progesterone ev...

BACKGROUND: Hormonal male contraception is based on the reversible suppression of LH and FSH resulting in intratesticular testosterone depletion with subsequent spermatogenic arrest and infertility. Tibolone, a unique synthetic steroid with mixed progestational, androgenic and oestrogenic activities, has been shown to suppress gonadotrophins, inhibit ovulation and postmenopausal hot flushes in women. HYPOTHESIS: We hypothesise that the hybrid anti-gonadotrophic action of Tibol...

Objectives: To assess the gonadotrophin suppressive effects of 2 doses of nomegestrol acetate (NOMA) alone and in combination with testosterone enanthate (TE) in men.To evaluate the potential effects of NOMA on circulating lipids in menMethods: Twelve healthy male volunteers were recruited. Subjects were randomly allocated to receive either NOMA 5 milligrams or NOMA 10 milligrams orally daily. Study duration included 28 days treatm...

Objective: To identify the optimal regime for physiological replacement in hypogonadism. We assessed the pharmacokinetics of 3 different dose-intervals for i.m. administration of the new parenteral formulation of testosterone undecanoate in castor oil (Schering AG Berlin).Methods: Ten hypogonadal subjects (primary n equals 4 or secondary n equals 6) with a baseline T at diagnosis of less than 7 nanomols per litre were recruited and randomly allocated int...

This research is a descriptive and analytic study which was carried out to investigate the Fasting Blood Sugar of first trimester and 24-28 weeks , and 50-gram Glucose Challenge Test at 24-28 weeks of gestational age in non-diabetic pregnant women and their effect on the infants' weight in Shariati Hospital in Tehran .The means of the Fasting Blood Sugar for the first trimester , 24-28 weaks and Glucose Challenge Test were 81.15 , 80.8 and 111.75 miligrams per deciliter re...

Because the sodium iodide symporter, NIS, may be artificially expressed in cells to introduce ablative doses of radioactive iodide, it may be of clinical use. NIS is normally found in the basolateral membrane of thyrocytes and its expression and activity are known to be regulated by TSH. We have used primary cultures of human thyrocytes to examine other regulators of NIS activity. NIS activity was measured as uptake of 125I into cells in the presence of the thyroper...

The synthetic retinoid N-(4-hydroxyphenyl)retinamide (4HPR) has manifold actions which may be involved in its chemopreventive effects on breast cancer growth and progression. Ceramide is a sphingolipid involved in the mammalian stress response and is implicated in the induction of apoptosis. Its role in the mechanism of 4HPR action has not been fully explored. Here we attempt to elucidate the relationship between 4HPR, ceramide production and cell viability. Survival of viable...

It is well established that oestrogens participate in the control of normal spermatogenesis and endogenous or environmental oestrogens are involved in pathological germ cell proliferation including testicular germ cell tumours. The effects of oestrogen are now known to be mediated by oestrogen receptor-α (ERα) and ERβ subtypes, but only ERβ has been found in human germ cells of normal testis. However, its expression was markedly diminished in seminomas, emb...