Endocrine Abstracts

Acromegaly secondary to a lung carcinoïd is a very rare entity. Secretion of GHRH (Growth hormone releasing hormone) or GHRH like by neuroendocrine tumor induces pituitary hyperplasia and a production of Growth hormone (GH) with or without others anterior pituitary hormones. Total resection of lung tumor induces normalisation of pituitary function as in our observation.AD, 37 years, male, came to our unit for diabetes mellitus and acromegaly. His ch...

Introduction: Primary pigmented nodular adrenocortical disease (PPNAD) is a rare cause of ACTH-independent Cushing’s syndrome in pediatric population. This entity due to genetic mutation has specific histological appearance and can be associated to Carney’s complex and McCune Albright syndrome. Our aim was to report a pediatric case in order to specify clinical and biological characteristics.Case report: A 6 year-old boy with no family or perso...

Introduction: Papillary thyroid carcinoma is characterized by a good prognosis and a slow progression. Its metastases are usually located in cervical lymph nodes. But, sometimes they can reach the lung and bones. Cerebral metastases are exceptional as they have been reported in only 4%. Single or multiple, they can be totally symptomatic, but they are life threatening and require specific care as in the following caseCase report: A man aged 56, was refer...

Background and aims: It has been demonstrated that the thyroid autoimmunity, during pregnancy, adversely affects the course of the pregnancy. The anomalies may be prior to the conception, hence the interest of studying the women during the genital activity period. Our objective was to determine the prevalence of the thyroiditis in childbearing age women.Materials and methods: Prospective study, on 270 childbearing age women. Study protocol: clinical exam...

Background and aims: The hypothyroidism may be prior to the conception, hence the interest of studying women during the genital activity period. Our objective was to determine the prevalence and the etiologies of the hypothyroidism in childbearing age women.Materials and methods: Prospective study, on 270 childbearing age women. Study protocol: clinical examination, urinary iodine, thyroid stimulating hormone (TSH), free thyroxine (FT4) and thyroid antib...

Introduction: Computed tomography (CT) scan is the first imaging method used to characterize adrenal lesions in order to select patients for surgical treatment. Our aim was to specify the performance of this tool in the work up of adrenal masses (AM) recruited in a department of Endocrinology.Material and methods: This retrospective study included 100 patients hospitalized in our department between 2008 and 2014 for adrenal tumors. After a systematic exc...

Introduction: Hyponatremia’s etiological diagnosis remains a challenge in the real life. Our aim was to report a patient who was sent for severe behavioral disorders revealing hyponatremia due to an isolated deficit in aldosterone. This observation emphasizes the extreme rarity of the disease which deserves to be reported.Case report: A young patient aged 34 with a history of autoimmune thyroiditis consulted for an acute and severe psychiatric syndr...

46, XY disorders of sex development are rare diseases secondary to gonadal dysgenesis (GD) and disorders of androgens synthesis or action. Familial forms of GD are very rare; we report here the observations of two siblings with 46, XY GD.The first patient whose parents were relatives, raised as a girl consulted at 3 years for ambiguous genitalia, at clinical exam we found a small phallus, partial fusion of labio-scrotal folds with one orifice at the phal...

Introduction: Iodine deficiency has serious consequences for both the mother and the offspring, it is a real public health problem. Our aim was to study the iodine status impact on thyroid parameters during the first trimester of pregnancy in women free of any current or previous thyroid disease.Patients and methods: Prospective study, on 145 pregnant women (mean age of 29.4±0.5 years) at 10.4±0.2 weeks of gestation. Women with disrupted thyroi...

Introduction: Hypothyroidism is known for its adverse effects for both the pregnant woman and her offspring. Our aim is to highlight the benefits of screening for hypothyroidism in all pregnant women with and without risk factors.Patients and methods: Prospective study, on 270 pregnant women. Women with disrupted thyroid balance, who smoke (active smoking confessed) and those followed for thyroid disease or taking medications that interfere with the thyr...