Endocrine Abstracts

IntroductionMorbid obesity is a very prevalent disease, bariatric surgery being a fundamental pillar in its treatment.ObjectiveTo analyze the results of weight loss at 1 year in patients operated on gastric bypass and sleeve at the Regional University Hospital (HRU) of Malaga.MethodsRetrospective observational study, with a follow-up period of 1 year, of 215 patie...

IntroductionSodium-glucose cotransporter-2 inhibitors (SGLT2i) are a new class of oral antidiabetic drugs used for the treatment of type 2 diabetes mellitus. Recently, the SGLT2i dapagliflozin was approved for use in type 1 diabetes (T1DM) as an add-on to insulin therapy.Material and methodsWe conducted a retrospective observational study which included demographic and clinical-analytical data from 16 patient...

IntroductionThe term factitious thyrotoxicosis is defined as an excess of thyroid hormone in the body caused by the ingestion of exogenous thyroid hormone. It can be intentional, usually in patients with psychiatric disorders, or accidentally. Another possible cause is the inappropriate use of thyroid hormone for the treatment of obesity, depression or infertility.Case reportWe present the case of a 32-year-o...

IntroductionGastrointestinal adverse effects such as nausea and vomiting are widely described for GLP-1 receptor agonists (arGLP-1). We highlight Semaglutide, a drug that needs to start its administration at a reduced dose, to be able to increase the dose later with better tolerance and adherence of the patient. Not doing it this way can lead the patient to have serious adverse effects such as incoercible vomiting or profuse diarrhea that entails serious...

Retinoic acid (RA) treatment has been used in the last decade for redifferentiation of metastatic thyroid cancer that have lost radioiodine uptake (RIup) with heterogeneous results.Aim: To evaluate the improvement of RIup after a course of RA treatment.Method: Retrospective analysis of 29 patients with radioiodine negative metastatic disease (17 men /12 women; 22 papillary, 4 follicular and 3 oncocytic tumours). RA was given at a d...

Background: Vitamin D deficiency is a worldwide health issue that affects more than one billion people. Few guidelines assess optimal dosing of vitamin D in general population, and although there is no international consensus, the optimum dosing for vitamin D3 and mainly calcifediol is not known.Objective(s): To assess the efficacy of calcifediol in the treatment of vitamin D deficiency, compared with therapeutic guidelines recommendations for cholecalci...

Introduction: Catecholamine-secreting tumours derived from the adrenal medulla and the nodes of the autonomic nervous system are known as pheochromocytomas or paragangliomas, respectively. Although their clinical manifestations are similar, their differentiation is important from an epidemiological and prognostic point of view and their possibility of being associated with genetic syndromes.Case report: We present a case of a 16 year old patient, with no...

Introduction: The defecatory strain in constipated people can raise the blood pressure and occasionally trigger cardiovascular events.Methods: Review of the patient’s clinical records and the relevant literature.Results: Clinical Case: A 53-year old woman with history of breast surgery for adenocarcinoma and chronical constipation had severe resistant hypertension in the previous three years; she had hypertensive crises with ...

Introduction: Thyroid-associated ophthalmopathy is the most frequent extrathyroidal manifestation of Graves’ disease. Its treatment is based on the administration of intravenous corticosteroids, and the clinical activity score (CAS), TSH-binding inhibitor immunoglobulin (TBII) and TSH-receptor antibodies (TRAb) have been classically used to measure the response to treatment. However, in recent studies [1] it has been observed that other analytical parameters such as chol...

Introduction: TKIs including anti-VEGF receptor activity have been approved for the treatment of patients with radioiodine resistant thyroid carcinomas. For lenvatinib arterial thromboembolic events are listed as adverse events of special interest. In the phase III study of SELECT trial, arterial thromboembolic events were reported in 3% of lenvatinib-treated patients and 1% in the placebo group. Most of the patients had predisposing factors. Only one myocardial infarct was re...