Searchable abstracts of presentations at key conferences in endocrinology

ea0070ep14 | Adrenal and Cardiovascular Endocrinology | ECE2020

Descriptive analysis of suprarrenal carcinoma in our center. Clinical characteristics and evolution

Damas-Fuentes Miguel , Martínez Montoro José Ignacio , Fernández Valero Andrea , José Picón-César María , Tinahones Madueño Francisco J

Introduction: Adrenocortical carcinoma (ACC) is a very rare entity with a variable clinical presentation.Objective: To review the casuistry of ACC in our center in the last 15 years and to assess clinical characteristics and evolution in our patients.Material and method: We searched cases of ACC from 2004 to December 2018 registered in the Pathology Department.Results: Fifteen cases were found, 9 women and 6 ...

ea0070ep26 | Adrenal and Cardiovascular Endocrinology | ECE2020

Success rate of adrenal vein sampling: A ten-year experience

Martínez Montoro José Ignacio , Damas Fuentes Miguel , Fernández Valero Andrea , Picón César María José , Tinahones Madueño Francisco José

Introduction: Adrenal vein sampling (AVS) is the gold standard test to distinguish between unilateral adenoma and bilateral hyperplasia in primary hyperaldosteronism. This is a technical complicated procedure with a variable success rate. Our aim was to report our 10-year-success rate and results as regards to this procedure.Material and Methods: Retrospective observational study including data from patients undergoing AVS between 2009 and 2019.<p cl...

ea0070ep105 | Bone and Calcium | ECE2020

A case of hyperparathyroidism due to ntrathorcic lipoadenoma

Montalban Mendez Cristina , González Lázaro Paloma , Contreras Pascual Cristina , Moreno Tirado Antonio , Silva Fernández Julia , Javier Gómez Alfonso Francisco , Gómez García Inés

Lipoadenoma is an uncommon benign lesión of the parathyroid gland (<1%) and it has most commonly described as non-functional, but also is a very rare cause of primary hyperparathyroidism. Since 1958 scientific literatura had described 54 cases all over the world and only six of that paratyroid lipoadenomas was extended into torax. A case of intrathoracic parathyroid lipoadenoma with hyperparathyroidism is described. A 69–year–old man was refered to our hos...

ea0070ep555 | Hot topics (including COVID-19) | ECE2020

Maturity-onset diabetes of the young type 5 (MODY 5): A case reporte

Contreras Pascual Cristina , González Lázaro Paloma , Montalbán Méndez Cristina , Moreno Tirado Antonio , Silva Fernández Julia , Gómez García Inés

The diagnosis of atypical non-autoimmune forms of diabetes mellitus, such as maturity onset diabetes of the young (MODY) presents several challenges, in view of the extensive clinical and genetic heterogeneity of the disease. In this report we describe a case of atypical non autoimmune diabetes associated with a damaging HNF1β mutation. A 39-years-old woman with normal weight (BMI 20’8 kg/m2), endometriosis, ex-smoker, fatty liver and uterus bicornis unic...

ea0073aep165 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Circulating microRNAs as predictive tool of the effectiveness of lifestyle intervention for weight loss

Clemente-Postigo Mercedes , Coin-Araguez Leticia , Jose Carlos Fernández-García , Alcaide-Torres Juan A , Bekay Rajaa El , Bernal-Lopez Maria Rosa , Macias-Gonzalez Manuel , Tinahones Francisco J

Background and aimsLifestyle modifications based on diet and exercise are common strategies for the treatment and prevention of obesity and related comorbidities. However, not all patients respond equally to similar weight loss intervention which compromise patient adherence. Strategies for predicting the individual response are required for improving intervention efficiency by personalized recommendations. microRNAs (miRNAs), small RNA particles which r...

ea0073aep293 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Effectiveness of semaglutide in obese patients with type 2 diabetes. a six-month clinical experience

Andrea Fernández Valero , José Ignacio Martínez Montoro , Ana María Gómez Pérez , Damas-Fuentes Miguel , Francisco José Tinahones Madueño

IntroductionSemaglutide is a glucagon-like peptide-1 receptor agonist which has shown important benefits in patients with type 2 diabetes mellitus (T2DM) in randomized clinical trials. Its commercialization in Spain began in May of 2019. The main purpose of this study was to analyze the effectiveness of this drug into routine clinical practice in patients with T2DM with a body-mass index above 30 kg/m2.Matherial and meth...

ea0073aep333 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Adherence to the mediterranean diet and metabolic syndrome: Potential relationship in patients candidates for bariatric surgery

Sara León Utrero , Mª del Carmen Andreo López , Torres Enrique Redondo , Mª del Carmen Serrano Laguna , Mª Luisa Fernández Soto

ObjectiveTo study the possible relationship between adherence to the Mediterranean diet and the metabolic syndrome. Material and methods: Retrospective observational study of patients evaluated in a prebariatric surgery consultation between November 2017 and November 2019, who were given a questionnaire of adherence to a Mediterranean diet. Anthropometric and analytical parameters related to the metabolic syn...

ea0073aep504 | Pituitary and Neuroendocrinology | ECE2021

Acromegaly: Knowing the enemy in order to win

Porras Mariana Gomes , Alexa Benítez Valderrama , Paola Parra Ramírez , Rosa García Moreno , Rojas Patricia Martin , Gumersindo Fernández Vázquez , Beatriz Lecumberri Santamaría , Cristina Álvarez Escolá

IntroductionAcromegaly is an uncommon chronic disease with an insidious course. Due to the high morbimortality it causes, its early diagnosis and treatment are priority. The three therapeutic pillars are surgery, pharmacological treatment and radiotherapy, alone or in combination.ObjectivesTo clinically, biochemically and histologically characterize patients with acromegaly under follow-up in a tertiary hospi...

ea0073aep521 | Pituitary and Neuroendocrinology | ECE2021

Outcomes and complications of endoscopic pituitary surgery: A single-center study

Taibo Rocio Villar , Alicia Santamaría Nieto , Paula Andújar Plata , Antía Fernández Pombo , María Gemma Rodríguez Carnero , Ignacio Bernabeu Morón

ObjectivesTo present the results of our series of endoscopic surgery of PA, performed in a third level hospital by an experienced team.MethodsRetrospective review of PA undergoing endoscopic surgery between 2011 – 2018 in our institution. Clinical variables and radiological characteristics and outcomes were collected at diagnosis, before surgery and for an average of 4.8 years of postoperative follow-up....

ea0073oc7.4 | Oral Communications 7: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Liver GPR55 regulates NAFLD progression from steatosis to fibrosis

Fernández Uxía , Fernández Fondevila Marcos , González Rellán María Jesús , Da Silva Lima Natalia , Buque Xabier , González Rodríguez Marta , Delgado Teresa , Varela Rey Marta V , Eva Novoa , Tojo Marta , Marta Miguel , Diéguez Carlos , Diéguez Miguel , DiéguezMaría Luísa , Arrese Marco , García-Monzón Carmelo , Mato Jose , Aspichueta Jose , Nogueiras Rubén

Background and aimsG protein-coupled receptor 55 (GPR55) is a putative cannabinoid receptor, and l-α-lysophosphatidylinositol (LPI) is its only known endogenous ligand. Although GPR55 has been linked to energy homeostasis in different organs, its specific role in lipid metabolism in the liver and its contribution to the pathophysiology of non-alcoholic fatty liver disease (NAFLD) remains unknown.MethodWe...