Endocrine Abstracts

Studies into estrogen receptor alpha (ERα), progesterone receptor (PGR) and the androgen receptor (AR) involvement in breast, uterine and prostate cancers has provided considerable insight into the molecular actions these receptors, but have thus far focused on each receptor individually and alone in different cell types. Here, whole genome expression microarray analysis and ChIP-sequencing in ZR-75-1 breast cancer cells, in response to combinations of 17β-estradiol ...

Background: The purpose of this study was to determine the incidence of premature luteinization in patients with polycystic ovary syndrome and compared the main determinants of success in IVF in PCOS patients with and without premature luteinization.Methods: Retrospective analysis of 180 PCOS women of Chinese Han origin with infertility who underwent controlled ovarian hyperstimulation (COH) with an exogenous gonadotropin/GnRH antagonist protocol. Hormon...

Objective: Acromegaly is a rare disease with multiple serious comorbidities. The aim of this study was to gather information on patients diagnosed with Acromegaly from 1955 through 2010.Materials and methods: Information on patients with pituitary adenomas diagnosed from 1950 has aldready been gathered and and imported to patient journals at the National University Hospital in Iceland. In this retrospective study information on patients diagnosed with Ac...

Chronic low-grade inflammatory condition is associated with metabolic pathologies such as obesity. However, the role exerted by local inflammation occurring in different fat depots, such as subcutaneous (SAT) versus visceral (VAT) adipose tissue (AT), is still under evaluation. Aim of the present study was to characterize the inflammatory state in adipose tissue of obese (OB: n=58, mean±S.D. BMI=47±9) vs normoweight (NOR: n=28, mean±...

Congenital combined pituitary hormone deficiency (CCPHD) is a rare disease.Although most of them are growth hormone deficient, growth retardation is not always the presenting symptom\. There is no normative data in children younger than 3 years regarding dose and frequency with rhGH treatment. The objective was to evaluate the timing of growth retardation and the first and second year growth response to rhGH compared to the mathematical growth prediction...

Background: The age of the onset of puberty is much lower today than in the past century, due to the stability of the socio-economic conditions, improved quality of life and overall health of the population.Materials and methods: We examined healthy 818 boys aged from 7 to 18 years, the study was conducted between 2009 and 2011.Boys were examined in three urban districts of Tashkent city (i.e. Mirzo-Ulugbek, Shakhantaur, Yunus-Abad...

Introduction: Pituitary adenomas with cavernous sinus involvement (CSI) are associated with serious clinical sequelae but are often incompletely excised during surgery. Contradictory viewpoints exist regarding management of residual tumors in the cavernous sinus with some authors suggesting use of adjuvant radiotherapy post-operatively for long term tumor control. But radiotherapy has been associated with hypopituitarism and increased mortality due to cerebrovascular causes. W...

Atheroma is accelerated in overt hypothyroidism (OH) and possibly in subclinical-hypothyroidism (SCH), and is not completely explained by increased LDL-cholesterol. There is little data available regarding post-prandial metabolic changes in OH or SCH.Subjects with OH (n=21), SCH (n=28) and age, sex and BMI matched controls (n=50) were studied fasting and for up to 8-h following a mixed-meal. Investigations included apolipoprotein(apo...

Introduction: The incidence of hyperthyroidism is influenced by iodine nutrition. Sweden is a long-term iodine sufficient (IS) area with an iodination fortification program since 1936.Methods: In 2003–2005, all referred cases of subclinical (SH) and overt hyperthyroidism (OH) were registered from a targeted population of 631239 individuals in Gothenburg. Information on age, gender, etiology, smoking, thyroid associated ophtalmopathy (TAO), thyroid h...

Both of peroxisome proliferator-activated receptor gamma (PPARγ) and estrogen receptor (ER) contribute to the development of thyroid cancer. Previously, the activation of ERα was found to promote the proliferation of thyroid cancer cells, whereas activation of either ERβ or PPARγ resulted in apoptosis of thyroid cancer cells. Furthermore, a transactivation between ER and PPARγ was reported in estrogen-responsive malignancy, such as breast cancer. Howev...