Searchable abstracts of presentations at key conferences in endocrinology

ea0011p94 | Clinical case reports | ECE2006

Systemic amyloidosis presenting with thyrotoxicosis: a case report

Fegan G , Rasbridge S , Taylor M

Although amyloid deposition can cause a goitre thyrotoxicosis secondary to amyloidosis is rare. We report a case of fatal systemic amyloidosis presenting as thyrotoxicosis.A 62-year-old previously healthy male presented with heat intolerance, weight loss and tremor. On examination he had moderate sized firm goitre and mild dysthyroid eye disease. Biochemistry confirmed thyrotoxicosis; serum free T4 47 pmol/l (normal 10–25) freeT3 14.4 pmol/l (normal...

ea0011p292 | Diabetes, metabolism and cardiovascular | ECE2006

Glucose metabolism, insulin secretion and insulin sensitivity in juvenile hemochromatosis

Angelopoulos N , Noutsou M , Goula A , Tolis G

Among specific diabetes subtypes secondary to pancreatopathies, hereditary hemochromatosis is an inherited disorder of iron metabolism, resulting to excessive iron overload and tissue damage in various organs. We report here the case of a man with the young-onset form of the disease and we describe his glycaemic status, before and during venesection therapy. A 25-year-old man attended our clinic in Athens, Greece, with hypogonadotropic hypogonadism due to hereditary hemochroma...

ea0011p314 | Diabetes, metabolism and cardiovascular | ECE2006

Challenge in Achieving Target Hba1c in a relatively rare Diabetes complication

Haq MU , Morrison G , Weston PJ

We present a case of 55 years old obese man with type 2 diabetes of 13 years duration, seen in diabetes clinic. His HbA1c had been 8–10% for about 7 years despite being on maximum doses of sulphonylurea and metformin.It was decided to start him on 30/70 mixed insulin and Metformin was continued. His HbA1c did not improve despite aggressive insulin titration. His injections became painful as insulin doses increased and resistance was noted on injecti...

ea0011p337 | Diabetes, metabolism and cardiovascular | ECE2006

Testosterone secretion and melatonin rhythm in men with the metabolic syndrome

Robeva R , Kirilov G , Kumanov Ph

Introduction: Low endogenous testosterone levels are related to the metabolic syndrome /MS/ and diabetes type 2 in middle-aged and elderly men, but little is known about interrelations testosterone-insulin in younger hyperinsulinemic men. Recent studies have shown that the night melatonin in males with hypogonadotropic hypogonadism is significantly higher in comparison with the healthy men, while it is significantly reduced in patients with hypergonadotropic hypogonadism. Howe...

ea0011p469 | Endocrine tumours and neoplasia | ECE2006

Octreotide as alternative to surgically adrenalectomy

Katalinic D , Mirosevic G , Zjacic-Rotkvic V

35-year old female patient with bilateral pheochromocytoma and operated medullary carcinoma of thyroid gland (MEN II B sy.) is put in the octreotide therapy as she doesn’t accept operation as a therapy because of religious reasons (transfusion of blood) and attacks of artery hypertension couldn’t be control with alfa-adrenergic receptors antagonists.12 MONTH 2004 ADRENALIN-urine 890 nmoldU/l (10.2–65.5); NORADRENALIN-urine >5000...

ea0011p570 | Growth and development | ECE2006

Maternal testosterone levels during pregnancy are associated with offspring size at birth

Carlsen SM , Jacobsen G , Romundstad P

Background: Animal studies have indicated that maternal androgen levels influence the intrauterine environment and development of the offspring. As human data are missing, we investigated the possible association between maternal androgens and offspring size at birth in humans.Methods: Randomly collected parous Caucasian women (n=147) were followed prospectively through pregnancy. Maternal serum levels of dehydroepiandrosterone sulphate (DHEAS), a...

ea0011p698 | Reproduction | ECE2006

Functional restoration of intact rabbit ovary after cryopreservation and transplantation

Chen C , Chen S , Wu G

Objective: Ovarian cryopreservation is an emerging technique that may advance breeding of endangered species and preservation of reproductive capacity in young women cancer patients who will undergo chemo/radiotherapy destruction of ovarian tissue.Materials and methods: A total of twelve mature female rabbits were used in experiment. Rabbits were anesthetized and then subjected to laparotomy. Bilateral oophorectomy was used to save one ovary as fresh con...

ea0010oc4 | Reproduction, neuroendocrinology and diabetes | SFE2005

The 3D cytoarchitecture of the VTA and the size of its dopaminergiccell population are permanently altered by perinatalglucocorticoid exposure

McArthur S , McHale|G##Gillies E

By including the synthetic glucocorticoid (GC), dexamethasone, in the maternal drinking water on gestational days 16–19 (0.5 μg/ml) or days 1–7 after birth (1.0 μg/ml), we have recently demonstrated (McArthur et al. J. Neuroendocrinol. 17: 475) that perinatal exposure of rat pups to GCs increased dopaminergic (DA) cell numbers in the adult ventral tegmental area (VTA) at −5.1 to −5.4 mm relative to Bregma (level I). In order to investig...

ea0010p6 | Clinical case reports/Governance | SFE2005

Lest an ‘old’ diagnosis be forgot – a case of disseminated osteolytic lesions and thyroid calcification

Simmgen M , Bano G , Nussey S

A 64 year-old Eritrean female presented with a toxic multinodular goitre. Free T4 was 37.8 pmol/L, TSH <0.01 mU/L, and a neck ultrasound scan showed areas of calcification. A Technetium scan revealed an increased tracer uptake of 9.8% with a right-sided dominant nodule and photopenic areas. An ablative dose of radio-iodine was administered as she did not tolerate thionamide therapy.Six months later the patient reported intermittent hoarseness of voic...

ea0010p32 | Diabetes, metabolism and cardiovascular | SFE2005

Is the mother always to blame?

Qureshi A , Homfray T , Nussey S , Bano G

In 1981 a 33yr old woman was diagnosed with Graves thyrotoxicosis and type 2 diabetes mellitus. At diagnosis her BMI was 19 kg/m2 and she was initially treated with carbimazole and glibenclamide. She had a past medical history of idiopathic lymphoedema, asthma and bronchopulmonary aspergillosis and was regularly reviewed by an ophthalmologist for hyperpigmented maculae.In 1991 she required insulin to control her diabetes and developed progress...