Searchable abstracts of presentations at key conferences in endocrinology

ea0006dp9 | Diabetes, metabolism and cardiovascular | SFE2003

Treatment of metabolic syndrome with topiramate. An open study

Messina G , Proietti R , Faroni J

Topiramate is an antiepileptic drug, with anoressant effect, known to positively modulate GABA receptors. There are some published data concerning the use of topiramate in mood disorders (expecially BED), while there are not know data on its use in obese patients without BED. This is a preliminary study to explane the effectiveness and tolerability of topiramate in non-Binge Eating Disorder (BED) obese patients with metabolic syndrome. We described the effects of topiramate, w...

ea0006dp18 | Diabetes, metabolism and cardiovascular | SFE2003

PHAEOCHROMOCYTOMA AND MULTIFOCAL GASTROINTESTINAL STROMAL TUMOURS:CARNEY TRIAD VARIANT OR A NEW SYNDROME?

Zachariah S , Bano G , Nussey S

Case: A GP with autoimmune hypothyroidism presented with a phaeochromocytoma during labour at the age of 36 y. A left adrenalectomy confirmed the diagnosis and a basal cell carcinoma was also removed. She had a history of Dupuytren's lesions of both soles and palms starting in her teenage years and multiple keratosis. There was no family history of any endocrine or skin disorder. At 41y, a benign breast lump was removed and also a gastrointestinal spindle cell stromal tumour (...

ea0006dp19 | Diabetes, metabolism and cardiovascular | SFE2003

Effect Of The Mode Of Conception On Incidences Of Apoptotic And Proliferative Cells In Full Term Human Placentas

Basir G , Cheung P , Cheung A , Lao T

Objectives: To compare the cell dynamics of term placental tissue in pregnancies conceived by in-vitro fertilization (IVF) and embryo transfer with spontaneous pregnancies.Methods: Placental samples were obtained from singleton term IVF pregnancies (n=25) and singleton term spontaneous pregnancies (n=30). Ethical approval was obtained from the Faculty of Medicine, The University of Hong Kong. The incidence of apoptotic and proliferative cells was determi...

ea0005p7 | Bone | BES2003

Effects of thyroid hormone (T3) on fibroblast growth factor signalling in bone

Barnard J , Williams A , Harvey C , Williams G

T3 and fibroblast growth factors (FGFs) are critical regulators of chondrocyte proliferation during bone formation and we identified recently that T3 modulates skeletal FGF receptor-1 (FGFR1) activity. FGFRs signal via several routes including mitogen-activated protein kinase (MAPK), STAT and phospholipase C gamma pathways. Mechanisms determining which pathways are activated by FGFRs are poorly understood but include alternative splicing of exons encoding variable domains with...

ea0005p72 | Cytokines and Growth Factors | BES2003

Relationships between IL-6 levels and anthropometric, metabolic and hormonal parameters in women with PCOS and the effect of treatment with metformin

Tsilchorozidou T , Mohamed-Ali V , Conway G

Over a third of women with polycystic ovarian syndrome (PCOS) display glucose intolerance and multiple risk factors for cardiovascular disease, including central obesity. Interleukin-6, a cytokine that is mainly derived from adipose tissue, has recently been implicated as an important link in the development of cardiovascular disease in obesity. We determined the relations between circulating Interleukin-6 levels and anthropometric, metabolic and hormonal parameters in 38 wome...

ea0005p207 | Reproduction | BES2003

Polycystic ovary syndrome (PCOS) has a significant negative impact on health-related quality of life (HRQoL)

Coffey S , Bano G , Mason H

PCOS is a chronic medical condition consisting of PCO on ultrasound in conjunction with menstrual cycle disturbance, insulin resistance, obesity and/or hyperandrogenism manifest as acne, hirsutism and androgenic alopecia. These symptoms can be expected to have a significant impact on quality of life. The aim of this study was to compare the health-related quality of life (HRQoL) of women with PCOS with that of women in the general population.HRQoL is generally measured by ...

ea0005p256 | Thyroid | BES2003

The type II and III iodothyronine deiodinase enzymes are expressed in differentiating growth plate chondrocytes

Robson H , Shalet S , Williams G

The thyroid hormones, L-thyroxine (T4) and 3,5,3'-triiodothyronine (T3), are essential for skeletal development and regulate bone mineralisation in the adult. T4 is a pro-hormone that is converted to active T3 by the type I and II 5'-iodothyronine deiodinase enzymes (D1 and D2). T4 and T3 are substrates for the type III 5-deiodinase enzyme (D3) which catalyses the irreversible production of inactive metabolites. The deiodinases are expressed widely in T3-target tissues and the...

ea0005p268 | Thyroid | BES2003

A managed clinical network for thyroid disease

Cuthbertson D , Jung R , Leese G

The high prevalence of thyroid disease necessitates efficient and effective monitoring. We expanded a hospital-based register to a managed clinical network for almost 10,000 patients with thyroid disease. Evaluation of our network compared to register data from 1991 demonstrates changing trends in treatment of hyperthyroidism. Use of radio-iodine significantly increased (58 percent v 44 percent; p less than 0.001) with a reduction in thyroid surgery (34 percent v 47 percent; p...

ea0004s19 | Maintenance of pregnancy | SFE2002

Immunology of implantation and pregnancy

Sargent I , Sacks G , Redman C

Recent advances in reproductive immunology have caused a fundamental shift in our appreciation of the nature of human pregnancy. For nearly 50 years, the subject has been dominated by Medawar's 'fetal allograft' hypothesis, in which an analogy is assumed between the fetus and a tissue transplant. In this framework, all maternal immune mechanisms are considered potentially harmful for the fetus and, therefore, must be overcome, bypassed or suppressed. Much progress has been mad...