Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1740 | Thyroid (non-cancer) | ICEECE2012

The influence of cure of subclinical hyperthyroidism on the level of serum triglycerides and cholesterol fractions

Kaminski G. , Zielinski G. , Podgorski J.

Introduce: Subclinical hyperthyroidism (SH) affects 0.2 - 11.8% of world human population and is associated with important cardiovascular risk factors. It remains controversial whether or not to treat patients with low serum TSH levels. Between unwanted potential outcomes of treatment of SH there is an elevation of the level of serum triglycerides and cholesterol which may be responsible for higher risk of cardiac death.Aim: To estimate an influence of c...

ea0083domnp1 | Diabetes, Obesity, Metabolism and Nutrition | EYES2022

Does phase angle analysis in overweight women be a surrogate marker of insulin resistance?

G Erta , G Gersone , P Tretjakovs

Background: Phase angle (PA) is defined as the angular displacement between the current and voltage waveforms due to capacitor interference, measured in degrees or radians. [1] The fat-free mass (FFM) is made up of water and electrolytes and is characterized by a low impedance, while the FM (fat mass) is water-free and, therefore, with a high impedance. The larger the FM, the higher the resistance, and this parameter affects the PA. Body mass index (BMI) is the most widely use...

ea0081s23.2 | Thyroid autoimmunity | ECE2022

Thyroid autoimmunity, subfertility and assisted reproduction

Poppe Kris G

Severe thyroid dysfunction may lead to menstrual disorders and subfertility via direct and indirect interactions with the hypothalamo–pituitary–ovarian axis and the reproductive organs. However, the exact prevalence of subfertility in women with thyroid disorders remains unknown. Fertility problems may persist after restoring normal thyroid function, and then surgery and/or an assisted reproductive technology (ART) may be necessary to obtain a pregnancy. The initial ...

ea0062wc5 | Workshop C: Disorders of the thyroid gland | EU2019

Interpretation of abnormal thyroid function tests

Eid Hatem , Bano G

Background: In the majority of cases, the results of TFTs are straightforward. In significant subgroup of patients, the interpretation of TFTs is more challenging, either because. The results appear discordant with the clinical picture (e.g. normal TSH in a patient with suspected thyrotoxicosis), Or measurements appear to contradict each other (e.g. raised TH concentrations, but with non-suppressed TSH).Case presentation: 29 year old Caucasian female com...

ea0044se1.4 | Senior Endocrinologists' Session | SFEBES2016

On gonads and gadflies: the oestrus angle

Hillier Stephen G

“In the Lucanian woods among the oaks ‖ Of green Alburnus’ slopes there swarms a fly ‖ (By us called gad-fly, oestrus by the Greeks). ‖ It's fierce and buzzes monstrously: whole herds ‖ In terror of it scatter through the woods, ‖ Until the sky rings with their bellowing…” Virgil, Georgics, Book III [K.R. Mackenzie's translation].Virgil's description of ...

ea0041mte9 | (1) | ECE2016

Treatment of male hypogonadism

Goulis Dimitrios G

Traditionally, male hypogonadism is classified into hypogonadotrophic (the archetype being Kallmann syndrome) and hypergonadotrophic (the archetype being Klinefelter syndrome). Late-onset hypogonadism (LOH) constitutes a separate entity that can be defined as the state where men of advanced age demonstrate low serum testosterone (T) concentrations in combination with a spectrum of symptoms reminiscent of those of ‘classic’ male hypogonadism (e.g. reduced sexual funct...

ea0059pl10 | Society for Endocrinology Jubilee Lecture | SFEBES2018

Ups and downs of nuclear receptor action

Parker Malcolm G

Nuclear receptors regulate many developmental processes and a vast array of physiological responses. They control the expression of subsets of specific genes by recruiting co-factors that can function either as co-activators or co-repressors to either stimulate or repress gene transcription. Using the ligand-binding domain of the estrogen receptor as bait we identified a receptor interacting protein of MW 140Kd that we called RIP140. Examination of RIP140 null mice showed two ...

ea0029s14.3 | Wnt/Beta-catenin in pituitary development and disease | ICEECE2012

Wnt signalling in oestrogen-induced lactotroph proliferation

Davis J. , Brabant G.

The anterior pituitary gland displays considerable plasticity with a proliferative response to oestrogen in a number of different situations including pregnancy. The nature of pituitary remodelling to this physiological demand is not clear.Using microarray analysis we found that oestrogen treatment of the rat in vivo increased expression of Wnt4 mRNA in adult rat pituitary tissue. Dual immunofluorescence analysis showed that this Wnt4 expression w...

ea0029oc9.4 | Endocrine Tumours & Translation | ICEECE2012

Functional characterization of mutations in the multiple endocrine neoplasia type 1 (MEN1) gene suggest therapeutic strategies

Canaff L. , Hendy G.

Menin is the product of the multiple endocrine neoplasia type 1 (MEN1) gene which when inactivated causes an autosomal dominant disorder characterized by tumors of the parathyroids, endocrine pancreas and anterior pituitary.We identified an MEN1 splice-site mutation leading to a menin Δ(184–218) mutant having an in-frame deletion of 35 amino acids, but otherwise of wild-type sequence. The transfected mutant was well expressed, and like wild-typ...

ea0029p225 | Calcium & Vitamin D metabolism | ICEECE2012

Quality of life in premenopausal women with vitamin D deficiency and vitamin D insufficiency

Ecemis G. , Atmaca A.

Introduction: The aim of this study was to compare quality of life among premenopausal women with vitamin D deficiency, vitamin D insufficiency and vitamin D sufficiency.Methods: Premenopausal women with chronic fatigue, myalgia and nonspecific body pain were divided according to their vitamin D levels: ≤20 ng/ml (vitamin D deficient, n=30), 21–29 ng/ml (vitamin D insufficient, n=30) and ≥30 ng/ml (vitamin D sufficient, ...