Searchable abstracts of presentations at key conferences in endocrinology

ea0029p238 | Calcium & Vitamin D metabolism | ICEECE2012

Role of chromogranin-A in the truncation of parathyroid hormone in cultured parathyroid cells from patients of the secondary hyperparathyroidism

Kanai G. , Sawada K.

Introduction: Two major assay systems have been used for evaluation of parathyroid hormone (PTH) secretion. Whole PTH (wPTH) recognizes full-length 84 amino acid residues [PTH(1–84)], and Intact PTH (iPTH) recognizes NH2-truncated forms, such as PTH(7–84), in addition to PTH(1–84). Patients with chronic renal failure have increased amount of PTH(7–84) in circulations, so that the ratio of wPTH/iPTH indicates 0.7 or below usually. On the other hand, chromogr...

ea0029p290 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Testosterone and cardiovascular risk in patients with erectile dysfunction

Corona G. , Rastrelli G. , Balercia G. , Sforza A. , Forti G. , Maggi M.

Background: The relationship between cardiovascular (CV) diseases (CVD) and testosterone levels in men has not been completely clarified.Aim: To evaluate the association between testosterone levels and CV risk in subjects with erectile dysfunction (ED) and to verify whether their body mass index might (BMI) represents a possible confounder in testosterone-related CV stratification.Material and methods: A consecutive series of 2269 ...

ea0029p887 | Female Reproduction | ICEECE2012

Role of the CRH receptors and brainstem noradrenergic nuclei in the gonadotropins secretion induced by acute stress at proestrus morning

Traslavina G. , Franci C.

Acute stressors can active the reproductive function depending on estrogen priming. Corticotropin-releasing hormone (CRH) has been implicated as mediator of stress-induced effects on hypothalamus–pituitary–gonadal axis (HPG), acting in the limbic system, paraventricular nucleus and noradrenergic (NA) neurons. Antalarmin and astressin2-B are selective CRH-R1 and CRH-R2 antagonists, respectively. We investigated the mediation of CRH-R1 and/or CRH-R2 receptors and of lo...

ea0029p1252 | Obesity | ICEECE2012

Hyperuricemia and components of metabolic syndrome among patients of different age

Povoroznyuk V. , Dubetska G.

Aim of research: To determine uric acid level in blood serum and incidents of hyperuricemia among women and men of different age and their relation with some components of metabolic syndrome.Object of research: Women (n=450) and men (n=120), age of examined patients was from 20 to 89 years old. They were divided into the following groups: I group (BMI=18.5–24.9), II group (BMI=25.0–29.9), III group (BMI=30.0–34.9), IV group (...

ea0029p1397 | Pituitary Clinical | ICEECE2012

Outcome of transsphenoidal surgery for Cushing’s disease dependent on tumor size: a single center experience

Dimopoulou C. , Stalla G.

Introduction: Transsphenoidal surgery (TSS) currently presents treatment of choice for Cushing’s disease (CD). Dependent on tumor size, remission rates after initial TSS range from 66 to 94%. In ACTH-secreting pituitary macroadenomas, remission rates are reported to be lower. Visible adenomas on preoperative MRI or intraoperatively and neurosurgical expertise might contribute to successful TSS.Design: A retrospective, single center analysis in 51 CD...

ea0028p28 | Clinical biochemistry | SFEBES2012

Tolvaptan for the treatment of hyponatraemia secondary to SIADH in cancer patients

Kenz Sami , Brabant G

Introduction: SIADH is frequently observed as a paraneoplastic secretion in many cancer types with the highest frequency described in small-cell lung cancer. The paraneoplastic secretion of ADH/vasopressin may induce hyponatraemia which is associated with increased morbidity and mortality. Conventional treatment of the condition consists of fluid restriction and demeclocycline. Tolvaptan, an oral V2-receptor antagonist, that directly targets the mechanism of SIADH, has been pr...

ea0026s13.3 | Endocrine response to critical illness | ECE2011

Novel insights in endocrine and metabolic changes during critical illness

Van den Berghe G

Host responses to critical illness, such as excessive inflammation and hyperglycemia, trigger detrimental chain reactions that damage cellular proteins and organelles. Such responses to illness contribute to the risk of non-resolving multiple organ dysfunction and adverse outcome. Autophagy is a bulk degradation pathway able to remove toxic protein aggregates and damaged organelles. Morphologically, both liver and muscle of critically ill patients reveal an autophagy-deficienc...

ea0026s22.1 | Non traditional effects of pituitary hormones | ECE2011

Non-thyroidal effects of TSH

Williams G R

The glycoprotein hormone, TSH, is synthesized and secreted by thyrotrophs in the anterior pituitary gland. It acts at the TSH receptor (TSHR), a 7-transmembrane G-protein coupled cell membrane receptor expressed in thyroid follicular cells. The TSHR, thus, plays a key role in the regulation of thyroid status and growth of the thyroid gland. In recent years TSHR expression has also been identified in a wide variety of extra-thyroidal tissues including: anterior pituitary; hypot...

ea0026s25.2 | GNAS locus: imprinting, animal models and human diseases | ECE2011

Epigenetic defects at the GNAS locus and human diseases

Mantovani G , Spada A

The two main subtypes of pseudohypoparathyroidism (PHP), PHP-Ia and -Ib, are caused by mutations in GNAS exons 1–13 and methylation defects in the imprinted GNAS cluster, respectively. PHP-Ia patients show Albright hereditary osteodystrophy (AHO), together with end-organ resistance to the action of different hormones that activate the Gs-coupled pathways, primarily PTH, TSH, gonadotropins, and GHRH. In PHP-Ib patients AHO is classically absent, Gsα acti...

ea0026p348 | Obesity | ECE2011

Body mass index, obesity and hyperuricemia in postmenopausal women

Povoroznyuk V , Dubetska G

Aim of research: To determine uric acid level in blood serum and incidents of hyperuricemia in postmenopausal women and their relation with body mass index (BMI).Object of research: Patients of clinic by the physiology and pathology of bone and joint disease department and Ukrainian medical-scientific center of osteoporosis: postmenopausal women (n=134). They were divided in the following groups depending on BMI: I group (BMI=20.0–24.9) &#150...