Searchable abstracts of presentations at key conferences in endocrinology

ea0007s20 | Neural migration in neuroendocrine systems | BES2004

Recent advances in the understanding of GnRH neuronal migration in mammals

Tobet S , Schwarting G

Gonadotropin releasing-hormone (GnRH or LHRH) regulates the hypothalamo-pituitary-gonadal (HPG) axis in vertebrates. GnRH neurons that regulate the HPG axis derive from progenitor cells in the nasal compartment and migrate along vomeronasal fibers across the cribriform plate into the forebrain. GnRH neurons migrate over a long route that provides many factors for guidance. Early in their migration, GnRH neurons always follow fibers; if fiber trajectories are altered, GnRH neur...

ea0007p131 | Growth and development | BES2004

Do prolonged courses of testosterone affect final height in extreme maturational delay?

Lee R , Butler G

Aim: Differentiating idiopathic hypogonadotrophic hypogonadism from extreme maturational delay can be difficult, so most boys receive testosterone (T) replacement until the diagnosis becomes clear. Standard 3 month T therapy for maturational delay does not diminish adult stature, so we set out to determine whether T treatment of greater than 6 months duration would have an adverse effect on final height (FH) in boys with the eventual diagnosis of extreme maturational delay.</p...

ea0006p76 | Thyroid | SFE2003

Urticaria The Presenting Symptom Of Thyrotoxicosis

Mousa A , Knight G

Urticaria and pruritis are rare skin manifestations of thyrotoxicosis, we present a case where the presenting symptom was generalized distressing urticarial rash.CaseA 39-year-old male presented with a history of itchy urticarial rash all over the body, treated unsuccessfully with antihistamines. Ten weeks after its onset he developed weight loss, palpitations and irritability. Blood tests showed him to be thyrotoxic (TSH 0.02 mIU/...

ea0005p201 | Reproduction | BES2003

Screening for iron deficiency and anaemia in adults with Turner syndrome

Ostberg J , Conway G

IntroductionWomen with Turner Syndrome (TS), characterised by the complete or partial absence of one X-chromosome in females, are reported to have an increased risk of coeliac disease, inflammatory bowel disease and angiodysplasia. These may contribute to iron deficiency and anaemia through malabsorption or blood loss. This study screened the serum ferritin and haemoglobin measurements in an adult TS population.MethodSerum ferritin concentrations were measured in 1...

ea0005p254 | Thyroid | BES2003

Thyroid hormone receptor (TR) activity is modulated by TRdeltabeta3 in a cell-, response element-, and TR isoform-specific manner

Harvey C , Williams G

Alternative splicing of the rat THRB gene produces thyroid hormone (T3) receptor (TR) beta isoforms 1-3 and also TRdeltabeta3, which lacks the DNA binding domain but binds T3. TRbeta1 is ubiquitous; TRbeta2 is found predominantly in pituitary and hypothalamus, whilst TRbeta3 and TRdeltabeta3 are expressed widely in a ratio that is tissue-specific and T3-dependent. We investigated the function of the newly identified TRbeta3 and TRdeltabeta3 isoforms by transient transfection a...

ea0004p4 | Bone | SFE2002

Determinants of bone density and height in women with Androgen insenstivity,46XY Gonadal dysgenesis and 46XX Gonadal dysgenesis

Trikudanathan S , Conway G

Low bone density in women with androgen insensitivity syndrome [AIS] has been attributed to both androgen and oestrogen deficiency. Tall stature in women with AIS has been attributed to the presence of the Y chromosome and to delayed closure of the epiphyses due to relative sex steroid deficiency. In order to gain greater insight into these interactions we have compared bone density and height in four groups of women-27 women with AIS, 15 women with 46XY gonadal dysgenesis, 25...

ea0003s24 | Metalloproteinases and Their Inhibitors: Regulators of Endocrine Activity | BES2002

Metalloproteinases and the modulation of growth hormone signalling

Baumann G , Frank S

Growth hormone (GH) signals through the GH receptor (GHR), a member of the cytokine receptor superfamily. The extracellular domain of the GHR exists as a soluble form known as the GH binding protein (GHBP). The GHBP is either derived from the GHR by proteolysis (man, rabbit) or from the GHR gene by alternative splicing (rodents). The GHBP circulates in blood and modulates GH action by i) altering GH kinetics, ii) competing with GHRs for ligand, and iii) unproductive GHR/GHBP h...

ea0003p116 | Diabetes &amp; Metabolism | BES2002

A pilot study of metformin for the treatment of hirsutism in patients without diabetes

Moleele G , Sturrock N

Aim: To determine whether metformin has beneficial effects on hirsutism in patientswithout diabetes mellitus.Methods: This was a randomised placebo controlled double blind parallel study of six months Metformin (1500milligrams per day)/placebo. The primary outcomes were change in hair growth rate on hirsutography and by Ferriman-Galwey score. Secondary endpoints were changes in biochemical parameters related to androgens and ins...

ea0003p302 | Thyroid | BES2002

Environmental factors produce variation within a model of thyroid eye disease

Baker G , Ludgate M

An established murine model of thyroid eye disease is induced by transfer of thyrotropin receptor (TSHR) primed T-cells to syngeneic recipients. Our aim was to extend the model to determine if: there are gender differences, Rundle's curve occurs and magnetic resonance imaging (MRI) could be applied as an in vivo marker. Orbital MRI on non-living mice used a surface coil and 1.5T MRI. 0.75mm slices have resolution sufficient to image ocular muscles. TSHR primed T-cells were gen...

ea0073s13.1 | Symposium 13: TGF-β signalling in ovaries in women with PCOS | ECE2021

Interplay between androgens and TGF-β signalling in the ovary

Knight Phil G

Theca cells are indispensable for female reproduction being the source of androgens required for follicular oestrogen synthesis and also for interacting with androgen receptors in the ovary and other somatic tissues. Differentiated theca interna cells acquire responsiveness to LH and other endocrine signals, including insulin, that upregulate the steroidogenic pathway leading to androgen biosynthesis. In addition, numerous intraovarian factors of thecal, granulosal and/or oocy...