Endocrine Abstracts

Introduction: Graves’ ophthalmopathy (GO) is an autoimmune disorder that constitutes a major clinical and therapeutic challenge. Current treatment options for moderate-to-severe GO include immunotherapy, orbital radiotherapy and decompression surgery. Limited drugs of proven efficacy are available for the treatment of people with GO. Given the role in the pathogenesis of GO of interleukin (IL)-6 expression in adipocytes, fibroblasts and macrophages, the proposed theory i...

Introduction: There has been an increase in the use of new drugs called immune checkpoint inhibitors (ICPI) used in advanced tumors. Clinical trials have also reported an increased risk of developing immune-related adverse events (IRAEs). Endocrine IRAEs may be particularly relevant.Material and Methods: This is a retrospective study. Patients treated with ICPI were obtained from Medical Oncology departament of the General University Hospital of Albacete...

Hyperandrogenism and virilization are infrecuent in postmenopausal women and may result from androgen-producing tumors. Androgen-secreting adrenal tumors are rare in clinical practice and often diagnosed as adrenocortical carcinoma, while benign androgen-secreting adrenal tumors are even more rare.Case presentation: A 63-year-old postmenopausal woman in follow-up for hypothyroidism reported hair loss, increased libido accompanied by deepening of the voic...

Small fish are excellent experimental models to screen endocrine-disrupting compounds, but current fish-based assays to detect endocrine disruption have not been standardized yet, meaning that there is not consensus on endpoints and biomarkers to be measured. Moreover, exposure conditions may vary depending on the species used as the experimental model or the endocrine pathway evaluated. Another drawback is the fact that most methods to detect endocrine disruption rely on the ...

BackgroundMultiple Endocrine Neoplasia type 1 (MEN 1) is a genetic syndrome caused by inactivating mutations of the menin gene, which predisposes to the development of endocrine tumors. The causative mutations, clinical manifestations, and age of tumor development are highly variable. The objective of this study is to describe the characteristics of patients with MEN1 in our hospital.Material and methodsWe pe...

Objective: To understand the factors associated with changes in thyroid nodule volume with previous benign citology.Material and Methods: This is a prospective single-center observational study. We included patients with a benign citology from March/2016 to May/2018 and ultrasound follow-up after 12–24 months. Initially we determined the nodule size (volume in ml), and its risk of malignancy was classified according to ATA 2015 criteria. Volume cha...

Introduction: The aim of this work is the evaluation of usefulness of radioactive seed localization (RSL) for the detection of cervical recurrence of thyroid cancer in order to improve the surgical outcome.Material and method: Six patients with thyroid cancer with cervical recurrences evidenced by ultrasound, cytology/Tg-FNAB were selected for this procedure. A 125I seed was placed in the metastatic lesion using a needle guided by ultrasound. ...

Objectives: We have examined the relationship between the hepatic enzymes and type 2 diabetes. We have analyzed if the levels of hepatic enzymes are associated with body weight, lipid profile and the treatment with metformin, thiazolidinediones or statins.Methods: 318 patients with type 2 diabetes were included and they were compared with 100 healthy subjects. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gammaglutamiltranspeptidas...

Introduction: The aim of our study was to determine the frequency of hypogonadism (H) in males with type 2 diabetes (T2D) and its relation with erectile dysfunction (ED) and obesity.Methods: We studied 107 diabetic males who came successively to an Endocrine consultation. The presence of H was determined by total testosterone (T) with an immunofluerescence method and free testosterone (fT) calculated with Vermeulen’s equation, defining H if T<2 ...

Background: Pancreatic Cancer (PC) is uncommon; however, it is one of the most deadly cancer types of all. New-onset diabetes (NOD) is associated with a higher risk of pancreatic cancer than general population, particularly if late-onset. An association between new-onset diabetes and increased mortality in patients with pancreatic cancer has been suggested but clinical relevant differences between those individuals with new-onset diabetes and those without are not well establi...