Endocrine Abstracts

Patients with non-alcoholic fatty liver disease (NAFLD) have a higher prevalence of cardiovascular disease, particularly patients with liver fibrosis. Studies have shown a relationship between epicardial fat/coronary calcium and myocardial ischemia.Aim: Quantify epicardial fat and coronary calcium assessed by computed tomography (CT) in patients with NAFLD. Additionally, determine whether patients with hepatic fibrosis quantitatively assessed by liver el...

Introduction: The immunohistochemical characterization of Pit-1, Tpit and SF-1 transcription factors allows the identification of the three adenohypophyseal cell lines and has been incorporated into the latest WHO classification of pituitary adenomas (PA). The aim of the present study was to quantify the protein expression of pituitary-specific transcription factors (TF) by immunohistochemistry (IHC) and to correlate these results with the identification based on hormonal prot...

Introduction: Ovarian cancer is the most lethal gynecological malignancy. Early diagnosis has a survival rate of 90%. Unfortunately, more than 70% of cases are diagnosed when the cancer has already metastasized, and survival rates do not exceed 30% in these cases. The sodium iodide symporter (NIS) is an integral plasma membrane glycoprotein expressed in the basolateral surface of the thyroid gland, where it mediates active transport of iodide. Radioiodide therapy (RAI) through...

Introduction: In patients with human immunodeficiency virus (HIV) infection, the prevalence of osteoporosis is higher in comparison with the general population. Anti-retroviral therapy (ART) use seems to be a possible risk factor there is also high prevalence of vitamin D deficiency among people living with HIV.Objectives: To describe bone mineral density (BMD) status in HIV-infected patients as well as its associated risk factors such as vit D levels.</...

Lipoadenoma is an uncommon benign lesión of the parathyroid gland (<1%) and it has most commonly described as non-functional, but also is a very rare cause of primary hyperparathyroidism. Since 1958 scientific literatura had described 54 cases all over the world and only six of that paratyroid lipoadenomas was extended into torax. A case of intrathoracic parathyroid lipoadenoma with hyperparathyroidism is described. A 69–year–old man was refered to our hos...

Aim: To describe the clinical and analytical characteristics of patients with hypopituitarism in the Endocrinology Department.Materials and methods: This was a descriptive, retrospective study with 70 patients diagnosed with hypopituitarism in the Endocrinology Department´s outpatient consultations with a follow-up of up to 44 years. The qualitative variables were expressed in frequencies and the quantitative variables showed a normal distribution e...

Objective: Incidentally discovered thyroid microcarcinomas (TMc) are tumors with a maximal diameter ≥1 cm, indetified during a detailed histopathology examination following a thyroidectomy performed for reasons not pertaining to malignancies of the thyroid gland.Methods: We included 1555 patients who underwent a total thyroidectomy for benign disease between January 2005 and December 2018. Patients with post-surgical pathology consistent with thyro...

The diagnosis of atypical non-autoimmune forms of diabetes mellitus, such as maturity onset diabetes of the young (MODY) presents several challenges, in view of the extensive clinical and genetic heterogeneity of the disease. In this report we describe a case of atypical non autoimmune diabetes associated with a damaging HNF1β mutation. A 39-years-old woman with normal weight (BMI 20’8 kg/m2), endometriosis, ex-smoker, fatty liver and uterus bicornis unic...

Objective: To compare 2 modalities of bolus-basal insulin therapy with aspart-detemir, according to the moment of administration of detemir (DET), before the lunch or bed-time, in type 1 diabetic patients with poor metabolic control.Methods: We conducted a prospective study of 40 type 1 diabetic patients, with poor metabolic control (HbAc 7–12%), randomized to receive treatment with 1 injection of DET before the lunch or bed-time and followed-up dur...

Neoplastic thyroid diseases (multinodular goiter (MNG), follicular adenoma, differentiated (DTC) and undifferentiated thyroid carcinoma) have a higher incidence in women than in men. In fact, in the last ten years, DTC is the only cancer increasing the frequency in women, with an incidence similar to ovarian carcinoma or lymphomas.TGFb is a secreted factor important in the normal function of the thyrocyte. It has two independent actions: a fast antiproli...