Searchable abstracts of presentations at key conferences in endocrinology

ea0014p602 | (1) | ECE2007

Endocrine and neuro-ophtalmologic correlates of primary empty sella

Bianchi Antonio , Gregori Bruno , Sacco Eugenia , Giampietro Antonella , Milardi Domenico , Fusco Alessandra , Accornero Neri , Pontecorvi Alfredo , De Marinis Laura

Background: Primary empty sella (ES) can be asymptomatic or associated with endocrine and neurological alterations, such as visual defects. Studies in a large number of patients is still lacking.Objective: To study visual deficit in ES and its relationship with hormonal status.Material and Methods: We recorded visual evoked potentials (VEP) by white/black, red/black, blue/black patterns. Isoluminance between red and blue checks all...

ea0073aep840 | Late Breaking | ECE2021

Markers of humoral and cell-mediated immune response in primary autoimmune hypophysitis: A pilot study

Chiloiro Sabrina , Giampietro Antonella , Angelini Flavia , Paolo Mattogno Pier , Tartaglione Tommaso , Lauretti Liverana , Pontecorvi Alfredo , De Marinis Laura , Bianchi Antonio

IntroductionPrimary autoimmune hypophysitis (PAHs) is a rare inflammatory disease of the pituitary gland. Although largely investigated, the pathogenesis of PAH is not completely clarified. We aimed to investigate the immune response in PAHs.Material and methodsSerum anti-pituitary and anti-hypothalamus antibodies (respectively APAs and AHAs) were investigated though an indirect immunofluorescence on monkey h...

ea0081p431 | Pituitary and Neuroendocrinology | ECE2022

Acromegaly and aging: a double hit against quality of life?

Gagliardi Irene , Chiloiro Sabrina , Vallillo Maria , Bondanelli Marta , Volpato Stefano , Giampietro Antonella , Bianchi Antonio , De Marinis Laura , Chiara Zatelli Maria , Rosaria Ambrosio Maria

Introduction: Acromegaly patients (ACRO) show increased morbidity that affects health and quality of life (QoL). Elderly ACRO are going to increase in the next few years, but evidence regarding their management is lacking.Aim: To evaluate physical, functional and cognitive performances of elderly ACRO and the relationship with QoL.Methods: Multicenter case-control study conducted on 42 older ACRO (≥ 65 years) compared to an a...

ea0081ep771 | Pituitary and Neuroendocrinology | ECE2022

The management of hypophysitis in Covid-19

Menotti Sara , Veleno Miriam , Giampietro Antonella , Chiloiro Sabrina , Mattogno Pier Paolo , Giorgio D'Alessandris Quintino , Lauretti Liverana , Gaudino Simona , Doglietto Francesco , Pontecorvi Alfredo , Marinis Laura De , Bianchi Antonio

Introduction: Literature has already described some cases of hypophysitis related to acute respiratory syndrome coronavirus 2 (SARS-Cov2). The pituitary is indeed target for the virus due to the angiotensin-converting-enzyme-2 expression. Hypophysitis patients present with mass effect and pituitary dysfunction related symptoms. ACTH and TSH deficiencies are the most reported, along with central diabetes insipidus (CDI). The best way to manage these hypophysitis is still undefi...

ea0090p409 | Pituitary and Neuroendocrinology | ECE2023

Inflammatory infiltrate in wild-type and non-wild-type GNAS somatotropinomas

Chiloiro Sabrina , Cicia Martina , Giampietro Antonella , Gessi Marco , Lauretti Liverana , Paolo Mattogno Pier , Carlino Angela , Olivi Alessandro , Rindi Guido , Pontecorvi Alfredo , De Marinis Laura , Doglietto Francesco , Bianchi Antonio

Introduction: Somatotropinomas are benign pituitary tumors with heterogeneous biological and clinical behavior. The tumor microenvironment (TME) is an environment generated by the interaction between tumor cells and the host immune system. It affects both the behavior of the tumor and the outcome of the therapy. The GNAS gene encodes the alpha subunit of G proteins associated with hormone receptors such as TSH, PTH, GHRH, FSH/lH, ACTH. Mutation of this gene has been associated...

ea0090p424 | Pituitary and Neuroendocrinology | ECE2023

The acro-TIME score: a new clinical, pathological and immune integrative approach to early identify acromegaly patients resistant to treatment with first generation somatostatin ligands

Chiloiro Sabrina , Giampietro Antonella , Gessi Marco , Lauretti Liverana , Mattogno Pierpaolo , Costanza Flavia , Carlino Angela , Olivi Alessandro , Rindi Guido , Pontecorvi Alfredo , De Marinis Laura , Doglietto Francesco , Bianchi Antonio

Somatotropinomas are benign pituitary tumors, with a heterogenous biological and clinical behavior. Tumor microenvironment reflects the interaction between tumor cells and the host immune system and may regulate tumor behavior and therapy outcome. We develop a scoring system that includes clinical, pathological and immune markers to early identify fg-SRLs resistant acromegaly pts. 43 acromegaly pts were included according the following criteria (1) first line treatment with su...

ea0090p438 | Pituitary and Neuroendocrinology | ECE2023

The Role of the GH Receptor Polymorphism as Prognostic Factor of Vertebral Fractures in Acromegaly Patients Resistant to First Generation SSAs and Treated with GH Receptor Antagonist or Second-Generation Somatostatin Ligand

Costanza Flavia , Chiloiro Sabrina , Giampietro Antonella , Mattogno Pierpaolo , Amato Infante , Angelini Flavia , Lauretti Liverana , Olivi Alessandro , Pontecorvi Alfredo , Doglietto Francesco , De Marinis Laura , Bianchi Antonio

Acromegaly is associated with skeletal fragility and an increased prevalence of vertebral fractures (VF). In recent years several authors have tried to investigate the markers that can predict the risk of bone fragility in this endocrine disorder. Two different isoforms of the GH receptor (GHR) have been described so far, which differ in the presence or absence of a transcript of exon 3 of the GHR gene. Both isoforms produce a functional receptor, but the exon 3-deleted isofor...

ea0090ep628 | Endocrine-related Cancer | ECE2023

Pancreas, An Unusual Metastatic Site In A Long-term Indolent Surviving Case, Under Somatostatin Analogues Therapy, Of Medullary Thyroid Carcinoma: A Case Report And Review Of Cases Documented In Literature

Raia Salvatore , Chiloiro Sabrina , Giampietro Antonella , Grazia Maratta Maria , Schinzari Giovanni , Attili Fabia , Gabriella Brizi Maria , Rufini Vittoria , De Marinis Laura , Pontecorvi Alfredo , Rindi Guido , Bianchi Antonio

Medullary thyroid carcinoma (MTC) accounts for 1%–2% of thyroid cancers and has a variable clinical course. MTCs present with locoregional metastasis in 50% of patients and distant metastasis in 10% to 15% at the time of initial diagnosis. The lungs, liver, and bone are common metastatic sites, and distant metastasis is known to be a poor prognostic factor for long-term oncologic outcomes. We present the long course case, under somatostatin analogues (SSA) therapy, of a 7...

ea0063gp59 | Acromegaly and GH | ECE2019

Effects of pegvisomant and pasireotide LAR on incidence of vertebral fractures in patients with acromegaly resistant to treatment with first-line somatostatin analogs

Chiloiro Sabrina , Giampietro Antonella , Bianchi Antonio , Bima Chiara , Frara Stefano , Mirra Federica , Donfrancesco Federico , Fleseriu Cara Maria , Fleseriu Maria , Giustina Andrea , Laura De Marinis , Pontecorvi Alfredo

Purpose: Osteopathy is an emerging complication of acromegaly characterized by increased bone turnover, deterioration in bone microarchitecture and high risk of vertebral fractures (VFs). In somatostatin analog (SSA)-resistant patients (pts), Pegvisomant (PegV) and Pasireotide LAR (Pasi) are used for acromegaly treatment, but their effect on skeletal health is still not defined.Methods: In a longitudinal international multicenter study, we evaluated inci...

ea0049ep997 | Pituitary - Clinical | ECE2017

Localization of the catheters during Bilateral sampling of the inferior petrosal sinuses can impact diagnostic power?

Chiloiro Sabrina , Pedicelli Alessandro , Valente Iacopo , Tartaglione Tommaso , Bianchi Antonio , Giampietro Antonella , Bima Chiara , Lauretti Liverana , Anile Carmelo , Pontecorvi Alfredo , De Marinis Laura

Introduction: Bilateral sampling of the inferior petrosal sinuses (IPSS) is considerate actually the best diagnostic test for Cushing.Patients and methods: We retrospectively reviewed our series of patients undergone IPSS for Cushing disease and we compared the difference between central and peripheral ACTH gradient in basal condition and after CRH stimulation in cases of localization of the tip of the catheters inside the inferior petrosal sinus or at t...