Searchable abstracts of presentations at key conferences in endocrinology

ea0063p1120 | Reproductive Endocrinology 2 | ECE2019

Immunomodulatory effects of dihydrotestosterone (DHT) in rat vaginal smooth muscle cells

Maseroli Elisa , Cellai Ilaria , Corno Chiara , Filippi Sandra , Comeglio Paolo , Sarchielli Erica , Rastrelli Giulia , Morelli Annamaria , Maggi Mario , Vignozzi Linda

Pathologies of the female reproductive system, characterized by chronic pain, are frequent and it has been hypothesized that inflammation may play an essential role in their pathogenesis. It is known that androgens, including dihydrotestosterone (DHT), have shown immunomodulatory effects in experimental models of chronic inflammation. The aim of this study was to evaluate the immunomodulatory effects of DHT in smooth muscle cells (rSMCs) isolated from vagina of intact Sprague-...

ea0035p692 | Male reproduction | ECE2014

Clinical implications of measuring prolactin levels in males of infertile couples

Lotti Francesco , Corona Giovanni , Maseroli Elisa , Rossi Matteo , Silverii Antonio , Degl'Innocenti Selene , Rastrelli Giulia , Forti Gianni , Maggi Mario

Introduction: Although in females of infertile couples abnormal PRL has a definitive role in the medical flow-chart, its role in males is less clear. Animal models suggest that PRL does not play a major role in male reproduction, although its trophic action on male accessory glands was often observed. Studies in humans are scanty. We systematically evaluated possible clinical and ultrasound correlates of PRL in males of infertile couples.Methods: Out of ...

ea0032p675 | Male reproduction | ECE2013

Investigation on psychological symptoms improves ANDROTEST accuracy in predicting hypogonadism in subjects with sexual dysfunction

Rastrelli Giulia , Corona Giovanni , Bandini Elisa , Strada Carolina , Maseroli Elisa , Ricca Valdo , Faravelli Carlo , Mannucci Edoardo , Maggi Mario

The role of psychological symptoms in recognizing late-onset hypogonadism (LOH) is still controversial. The aim of the study is to evaluate the association between LOH and specific psychological symptoms and to verify whether investigating intra-psychic domain improves the accuracy of a validated case-history tool (ANDROTEST) in detecting LOH. A consecutive series of 1009 subjects (mean age 49.23±13.34) consulting for sexual dysfunction was studied. Intra-psychic symptoms...

ea0032p758 | Obesity | ECE2013

Body weight loss reverts obesity-associated hypogonadotropic hypogonadism: a meta-analytic study

Corona Giovanni , Rastrelli Giulia , Monami Matteo , Saad Farid , Luconi Michaela , Lucchese Marcello , Sforza Alessandra , Forti Gianni , Mannucci Edoardo , Maggi Mario

Introduction: Few randomised clinical studies have evaluated the impact of diet and physical activity on testosterone levels in obese men with conflicting results. Conversely, studies on bariatric surgery in men generally showed an increase in testosterone levels. The aim of the present study is to perform a systematic review and meta-analysis of available trials on the effect of body weight loss on sex hormones levels.Methods: An extensive Medline searc...

ea0026p315 | Obesity | ECE2011

Testosterone and metabolic syndrome: a meta-analysis study

Corona Giovanni , Monami Matteo , Rastrelli Giulia , Abersa Antonio , Tishova Yuliya , Saad Farid , Lenzi Andrea , Forti Gianni , Maggi Mario

Introduction: Metabolic syndrome (MetS) is often associated with male hypogonadism. The role of testosterone replacement therapy (TRT) in MetS has not been completely clarified.To systematically analyse the relationship between androgen levels and MetS we performed a review and meta-analyses of available prospective and cross-sectional studies. A specific meta-analysis on the metabolic effects of TRT in available randomised clinical trials (RCTs) was als...

ea0022oc1.4 | Diabetes and obesity | ECE2010

The effect of statin therapy on testosterone levels in subjects consulting for erectile dysfunction

Corona Giovanni , Boddi Valentina , Balercia Giancarlo , Giulia Rastrelli , de Vita Giulia , Sforza Alessandra , Forti Gianni , Mannucci Edoardo , Maggi Mario

Introduction: Previous clinical studies on effect of statins treatment on testosterone levels have produced mixed results. The aim of the present study is to evaluate the association between statin therapy and hormonal parameters in a large series of subjects seeking medical care at our Unit for ED.Methods: A consecutive series of 3484 (mean age 51.6±13.1 years) patients with ED was studied.Several hormonal and biochemical par...

ea0081p309 | Calcium and Bone | ECE2022

Testosterone supplementation and bone parameters, a systematic review and meta-analysis study

Vena Walter , Corona Giovanni , Pizzocaro Alessandro , Giagulli Vito , Francomano Davide , Rastrelli Giulia , Aversa Antonio , Marcello Isidori Andrea , Pivonello Rosario , Vignozzi Linda , Mannucci Edoardo , Maggi Mario , Ferlin Alberto

Background: Testosterone (T) is essential for bone health during all ages, helping to achieve a proper peak bone mass and, later, to maintain bone density and strength. Guidelines on management of male osteoporosis recommend testosterone replacement in young-adult hypogonadal to prevent bone loss and anti-resorbitive drugs in case of high fracture risk, but the role of T replacement therapy (TRT) alone in subjects with late onset hypogonadism is still the object of an intense ...

ea0063oc14.1 | Sex Hormones | ECE2019

Testosterone replacement therapy is able to reduce prostate inflammation in men with BPH, metabolic syndrome and hypogonadism: preliminary results from a randomized placebo-controlled clinical trial

Rastrelli Giulia , Cipriani Sarah , Lotti Francesco , Cellai Ilaria , Comeglio Paolo , Boddi Valentina , Della Camera Pierandrea , Gacci Mauro , Serni Sergio , Maggi Mario , Vignozzi Linda

Objectives: BPH is characterised by prostate inflammation, which frequently occurs in men with metabolic syndrome (MetS). MetS is often associated with low testosterone (T). Recent evidence shows that low, rather than high, T is associated with BPH/lower urinary tract symptoms (LUTS). To evaluate if T replacement therapy (TRT) for 6 months in BPH men with MetS and low T, is able to improve LUTS and prostate inflammation.Methods: 120 men in waiting list f...

ea0063gp65 | Reproductive Axis | ECE2019

Testosterone replacement therapy outcomes in subjects with Klinefelter syndrome: preliminary results from a meta-analysis study

Vena Walter , Pizzocaro Alessandro , Pelliccione Fiore , Pivonello Rosario , Radicioni Antonio , Selice Riccardo , Rastrelli Giulia , Pasquali Daniela , Calogero Aldo Eugenio , Ferlin Alberto , Francavilla Sandro , Garolla Andrea , Corona Giovanni

Background: In patients with Klinefelter syndrome (KS) morbidity and mortality seem to be higher than general population, this depending on a wide number of possible comorbidities. Impaired metabolic profile, increased risk of venous thrombosis and the consequent increase of cardiovascular diseases might play a key role in this condition as well as reduced bone mineral density and higher fracture risk. Nowadays testosterone replacement therapy (TRT) is the first-choice treatme...

ea0063p598 | Diabetes, Obesity and Metabolism 2 | ECE2019

Physical activity counteracts metabolic syndrome-induced hypogonadotropic hypogonadism and erectile dysfunction in the rabbit

Morelli Annamaria , Filippi Sandra , Comeglio Paolo , Sarchielli Erica , Cellai Ilaria , Danza Giovanna , Rastrelli Giulia , Corno Chiara , Zizza Michela , Guarnieri Giulia , Vignozzi Linda , Maggi Mario

Metabolic syndrome (MetS) clusters cardiovascular and metabolic risk factors, along with hypogonadism (HG) and erectile dysfunction (ED). Lifestyle modifications, including physical exercise (PhyEx), are well-known treatments for this condition. We previously established a non-genomic, high-fat diet (HFD)-induced rabbit model of MetS that recapitulates the human phenotype, including HG and ED. We now report studies on the effect of PhyEx on hypothalamus-pituitary-testis (HPT) ...