Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep996 | Thyroid (non-cancer) | ECE2016

Transforming growth factor β1 in postpartum thyroiditis

Zielinska Anna , Maciulewski Rafal , Siewko Katarzyna , Poplawska-Kita Anna , Kozlowska Gabryela , Lipinska Danuta , Gorska Maria , Szelachowska Malgorzata

Introduction and aims: TGF-β1 participates in the pathogenesis of autoimmune diseases e.g. diabetes, Hashimoto disease, autoimmune digestive system disorders. The aim of our study was to evaluate TGF-β1 levels during pregnancy and after childbirth in women who developed postpartum thyroiditis (PPT) in comparison to the healthy control group (CG) and women with positive anti-thyroid antibodies (ATA+) who did not develop PPT.Material and method: ...

ea0037gp.06.04 | Reproduction: Female and PCOS | ECE2015

Phenotypic characteristic of type 1 diabetic women with polycystic ovary syndrome

Lebkowska Agnieszka , Adamska Agnieszka , Karczewska-Kupczewska Monika , Nikolajuk Agnieszka , Otziomek Elzbieta , Milewski Robert , Wolczynski Slawomir , Gorska Maria , Kowalska Irina

Introduction: The prevalence of polycystic ovary syndrome (PCOS) is increased in women with type 1 diabetes (T1DM) in comparison to the general population. It has been suggested that exogenous insulin administered to T1DM women in supraphysiological doses could act as co-gonadotropin and lead to disturbances observed in PCOS.Aim: The aim of this study was to evaluate the phenotypic characteristic and differences between diabetic women with PCOS (T1DM+PCO...

ea0037gp.26.02 | Thyroid – hypothyroidism | ECE2015

High serum IgG4 concentrations in patients with Hashimoto's thyroiditis

Poplawska-Kita Anna , Kosciuszko-Zdrodowska Maria , Siewko Katarzyna , Telejko Beata , Hryniewicka Justyna , Milewski Robert , Szelachowska Malgorzata , Gorska Maria

Purpose: Recent reports strongly suggest that at least some cases of Hashimoto’s thyroiditis (HT) may be closely associated with IgG4-related disease. In the present study we aimed to find out, whether the measurement of serum IgG4 allows for an identification of distinct types of HT, with different clinical, sonographic and serologic characteristics.Methods: The group studied consisted of 53 patients with HT and 28 healthy individuals. All the part...

ea0035oc4.1 | Diabetes and Obesity 1 | ECE2014

The lower postprandial glucose oxidation in nondiabetic carriers of risk variants of TCF7L2 gene

Adamska Edyta , Kretowski Adam , Goscik Joanna , Waszczeniuk Magdalena , Wawrusiewicz-Kurylonek Natalia , Citko Anna , Ciborowski Michal , Maliszewska Katarzyna , Gorska Maria

Introduction: The transcription factor 7-like 2 gene (TCF7L2) has the strongest effect on the risk of type 2 diabetes but the mechanism for this is not fully understood. Some genetic variants are associated with pancreatic B-cell function and some single nucleotide polymorphisms show a significant correlation with obesity. The aim of the study was to analyze whether TCF7L2 variants may influence body weight and body fat content, as well as postprandial glucose metabolism in no...

ea0035p367 | Diabetes (epidemiology, pathophysiology) | ECE2014

Serum cytokines and proinflammatory markers in first degree relatives of patients with type 1 diabetes

Szelachowska Malgorzata , Siewko Katarzyna , Poplawska-Kita Anna , Telejko Beata , Zielinska Anna , Maciulewski Rafal , Lipinska Danuta , Gorska Maria

Background and aims: In patients with type 2 diabetes, elevated tumor necrosis factor α (TNFα), C-reactive protein (CRP), chemerin, fetuin-A, have been reported. However, it is not entirely clear whether these alterations in adipokine serum concentrations are already present in prediabetic states and in type 1 diabetes. The aim of the study was to investigate whether adipokine profiles (chemerin, fetuin-A, TNFα) and inflammatory markers (CRP) are associated with...

ea0035p368 | Diabetes (epidemiology, pathophysiology) | ECE2014

Increased prevalence of anti-thyroid and anti-gastric parietal cell antibodies in first degree relatives of patients with type 1 diabetes

Siewko Katarzyna , Poplawska-Kita Anna , Telejko Beata , Maciulewski Rafal , Zielinska Anna , Lipinska Danuta , Gorska Maria , Szelachowska Malgorzata

Aim: It is well known that T1D is associated with other autoimmune diseases. The aim of this study was to compare the prevalence of various auto-antibodies in first-degree relatives of patients with T1D and healthy individuals with negative family history of diabetes.Material and methods: The group studied consisted of 90 relatives and 60 healthy individuals. Serum concentrations of antibodies to anti-21-hydroxylase (21-OH-Abs), anti-gastric parietal cel...

ea0035p663 | Female reproduction | ECE2014

Plasma adhesion molecules concentrations in women with type 1 diabetes mellitus and polycystic ovary syndrome

Lebkowska Agnieszka , Karczewska-Kupczewska Monika , Nikolajuk Agnieszka , Adamska Agnieszka , Otziomek Elzbieta , Wolczynski Slawomir , Gorska Maria , Kowalska Irina

Introduction: Polycystic ovary syndrome (PCOS) and type 1 diabetes (T1DM) are accompanied by an increased risk of cardiovascular complications. The higher prevalence of PCOS in T1DM was reported and thus T1DM women with PCOS exhibit a higher risk of cardiovascular diseases. Soluble E-selectin (sE-selectin) and intercellular adhesion cell molecule-1 (sICAM-1) are considered as an early markers of atherosclerosis.Aim: We aimed to evaluate plasma levels of ...

ea0035p978 | Thyroid (non-cancer) | ECE2014

Body mass analysis in patients with Hashimoto thyroiditis

Poplawska-Kita Anna , Siewko Katarzyna , Telejko Beata , Kosciuszko-Zdrodowska Maria , Hryniewicka Justyna , Szelachowska Malgorzata , Milewski Robert , Gorska Maria

Introduction: Thyroid hormones deficiency in the course of subclinical and overt hypothyroidism is frequently related to the increased body mass, reduced thermogenesis and metabolic rate however the pathogenesis of improper body mass in Hashimoto thyroiditis (HT) patients is still an open question. Therefore, in the present study we compared body mass and body composition between the patients with Hashimoto thyroiditis who were in clinical and hormonal euthyreosis and healthy ...

ea0032p415 | Diabetes | ECE2013

Association between type 1 diabetes and oral health status

Poplawska-Kita Anna , Siewko Katarzyna , Szpak Piotr , Krol Beata , Telejko Beata , Mysliwiec Janusz , Stokowska Wanda , Gorska Maria , Szelachowska Malgorzata

Aims: We assessed periodontal status in patients with type 1 diabetes and healthy individuals in relation to their glycemic control, smoking, and inflammatory biomarkers.Methods: Periodontal status was examined in 107 patients with type 1 diabetes and 40 controls, using oral hygiene index (OHI), community periodontal index (CPI) and teeth number. CPI values of 0–2 and 3–4 were classified as non-periodontitis and periodontitis respectively. Bloo...

ea0022p152 | Cardiovascular endocrinology and lipid metabolism | ECE2010

Relationship between serum IL-12 and p40 subunit concentrations and lipid parameters in obese subjects

Nikolajuk Agnieszka , Kowalska Irina , Adamska Agnieszka , Karczewska-Kupczewska Monika , Otziomek Elzbieta , Lebkowska Agnieszka , Gorska Maria , Straczkowski Marek

Numerous studies indicate an association between low-grade chronic inflammation and predisposition to type 2 diabetes and atherosclerosis. IL-12 is a proinflammatory cytokine with proatherogenic properties. IL-12 is a disulfide-linked, 70 kDa (p70) heterodimeric glycoprotein composed of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. Many data reported higher levels of p40 subunit than total IL-12. The aim of the present study was to estimate serum IL-12 and p40 subunit in ...