Searchable abstracts of presentations at key conferences in endocrinology

ea0016p662 | Signal transduction | ECE2008

Corticotropin releasing hormone receptor signalling pathways and regulation of NOSIII activity in syncytialized BeWo cells

Delidaki Maria , Gu Mei , Vatish Manu , Grammatopoulos Dimitris

Placental corticotrophin releasing hormone (CRH) appears to play important physiological roles during pregnancy and labour. In the placenta, CRH appears to regulate diverse actions such as human trophoblast cell grown and invasion, tissue remodeling, direct modulation of the placental prostaglandin generation and bioavailability and control of placental vascular tone through regulation of endothelial NOS (NOSIII) expression and activation1. CRH actions are mediated ...

ea0086p129 | Reproductive Endocrinology | SFEBES2022

Adipocytes-Derived Extracellular Vesicle-miR-26b Induces the process of Polycystic Ovary Syndrome

Zhou Guannan , Gu Yuanyuan , Zhou Fangyue , Hua Keqin , Ding Jingxin

Background: Adipocyte cells could produce numerous extracellular vesicles and orchestrate the balance of endocrinological system. Polycystic ovary syndrome (PCOS) is a refractory reproductive disease and also a kind of endocrine and metabolic disease. The aim of the study was to explore the effects of adipocyte-derived extracellular vesicles-miR-26b on cumulus cells (CCs) and development of PCOS.Methods: The crosstalk mediated by extracellular vesicle-mi...

ea0035p491 | Diabetes therapy | ECE2014

The favourable effects of autologous hematopoietic stem cell transplantation on the immune system in patients with type 1 diabetes

Li Li , Gu Weiqiong , Ye Lei , Yang Minglan , Wan Bin , Hong Jie , Wang Weiqing , Ning Guang

Objective: Autologous hematopoietic stem cell transplantation (AHSCT) is a promising treatment to reverse type 1 diabetes (T1D) in patients with significantly improved β-cell function. This study was designed to investigate the potential immunological mechanisms involved.Design and methods: 18 newly-diagnosed T1D were divided into two groups, the AHSCT group and the insulin therapy group. Blood mononuclear cells (PBMCs) of the patients at the baseli...

ea0070aep1070 | Hot topics (including COVID-19) | ECE2020

Efficacy of lanreotide autogel for chinese patients with active acromegaly with or without prior pituitary surgery: A post hoc analysis of the Lantern study

An zhenmei , Lei Ting , Duan lian , Zhang Lihui , Zhou Su , Shi Xiaofeng , Feng Gu

Background: Previous studies have yielded conflicting results on biochemical control with medical therapy in patients with or without prior pituitary surgery. The LANTERN study (NCT02493517) demonstrated that lanreotide autogel (LAN ATG) was non-inferior to lanreotide prolonged release (LAN PR) in Chinese patients with active acromegaly. This post hoc analysis of the LANTERN study aimed to explore the efficacy of LAN ATG in patients with or without prior pituitary surgery....

ea0070aep1081 | Hot topics (including COVID-19) | ECE2020

Efficacy of lanreotide autogel in Chinese patients with acromegaly according to tumor size: A post hoc analysis of the LANTERN study

An Zhenmei , Lei Ting , Duan lian , Zhang Lihui , Zhou Su , Shi Xiaofeng , Feng Gu

Background: The LANTERN study (NCT02493517) has demonstrated that lanreotide autogel (LAN ATG) was non-inferior to lanreotide prolonged release (LAN PR) in Chinese patients with active acromegaly. This post hoc analysis of the LANTERN study assessed the impact of tumor size on treatment effect.Design: In the LANTERN study, LAN ATG was started at 90 mg and subsequently titrated according to GH and IGF-1 levels for 32 weeks. Tumor diameters > 10 mm wer...

ea0032p906 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Treatment with pasireotide LAR normalizes prolactin levels in patients with acromegaly and hyperprolactinemia: randomized, double-blind, 12-month, phase III study

Colao Annamaria , Freda Pamela , Gu Feng , Resendiz Karina Hermosillo , Ruffin Matthieu , Chen YinMiao , Bronstein Marcello

Introduction: Around 20–30% of patients with acromegaly have hyperprolactinemia, which is associated with infertility and gonadal/sexual dysfunction. Current therapy involves somatostatin analogues for GH/IGF1 excess and a dopamine agonist to decrease prolactin levels. The objectives of this analysis were to assess treatment with pasireotide LAR or octreotide LAR alone in patients with acromegaly and hyperprolactinemia.Methods: Patients with acromeg...

ea0029oc12.5 | Obesity Clinical | ICEECE2012

Brown adipose tissue activation is inversely related with central obesity and metabolic parameters in adult human

Wang W. , Wang Q. , Zhang M. , Xu M. , Gu W. , Qi L. , Li B. , Ning G.

Background: Recent studies have shown that adult human possess active brown adipose tissue (BAT), which might be important in affecting obesity and related metabolic risk. However, the supporting evidence in large population based studies is sparse.Methods: We studied 4011 (2688 males and 1323 females) tumor-free Chinese adults aged 18–89 for BAT activities, visceral/subcutaneous fat areas and metabolic parameters. In vivo 18F-fluorodeoxygluc...

ea0029p1217 | Obesity | ICEECE2012

Serum liver fatty acid binding protein levels correlate positively with obesity and insulin resistance in chinese young adults

Shi J. , Hong J. , Gu W. , Zhang Y. , Cui B. , Yan Q. , Wang W. , Ning G.

Clear evidence on the specific impact of fatty acid binding proteins (FABPs) on cell biology and lipid metabolism in complex systems had been lacking until FABP-deficient mice models were created. Surprisingly, no change in appearance, gross morphology or viability was observed in FABP1-deficient mice. However, metabolic parameters in mice upon exposure to high-fat/cholesterol diet differed between studies. Therefore, liver fatty acid-binding protein (also called FABP1) plays ...

ea0026p32 | Adrenal cortex | ECE2011

Mission study: an international observational study on the mortality in Cushing’s syndrome

Pivonello R , Melnichenko G , Zacharieva S , Gu F , Oscar B , Shah N S , Gaillard R , Colao A

Cushing’s syndrome (CS) is a rare but severe disease associated with an increased mortality especially due to cardiovascular diseases, and associated with various systemic complications, including hypertension, glucose intolerance or diabetes mellitus, dyslipidemia and coagulopathy. Few studies have systematically evaluated the mortality of CS in a large and worldwide population of CS. The MISSION study is a retrospective study aimed at assessing the mortality in a large ...

ea0014p195 | (1) | ECE2007

Effect of supervised structured exercise program for 16 weeks on metabolic, pulmonary and cardiovascular parameters in obese adolescents

Guízar-Mendoza Juan , Linares Benigno , Amador Norma , Barbosa Gloria , Malacara Juan

Objective: To investigate whether a supervised structured exercise program by 16 weeks improves metabolic, pulmonary and cardiovascular parameters in obese adolescents.Material and methods: We included 38 obese adolescents between 12–15 years old. They participated in a supervised exercise program by 90 minutes, 5 days a week during 16 weeks. At baseline and at the end of the exercise program, we evaluated cardiorespiratory fitness, anthropometric m...