Searchable abstracts of presentations at key conferences in endocrinology

ea0021p329 | Steroids | SFEBES2009

Metyrapone interference in serum cortisol immunoassay

Halsall David , Owen Laura , Viljoen Adam , Taylor Kevin , Simpson Helen , Chatterjee Krishna , Gurnell Mark

Metyrapone (MT) is used in the medical management of Cushing’s syndrome as it decreases serum cortisol (CT) levels by inhibiting adrenal β-hydroxylation of 11-deoxycortisol, the final step in CT synthesis. CT precursors, in particular 11-deoxycortisol (DOC), increase following MT therapy. Monitoring glucocorticoid replacement in patients taking MT could therefore be confounded as DOC cross-reacts in commonly used immunoassays (IA) for serum CT. Serum CT results from ...

ea0013p81 | Clinical practice/governance and case reports | SFEBES2007

Use of anti thyroid hormone receptor antibody (TRAB) in Graves’ Disease

Myint Khin Swe , Andappa Gayathridevisa Shankargall , MacFarlane Ian , Gurnell Mark , Wood Diana , Chatterjee Khris , Simpson Helen

TRAB antibody is specific for diagnosis of Grave’s disease. We have conducted an audit to on our practice on parameters which TRAB could influence.Method: TRAB (NR 0–1 IU/l) positive patients were identified from biochemistry laboratory form April 2003 to February 2004. Sixty case notes were randomly selected for reviewed. Data were analysed subsequently.Result: 46 cases (77%) were female. Mean age was 42, range 6 to 78 y...

ea0013p90 | Clinical practice/governance and case reports | SFEBES2007

Primary hyperparathyroidism in pregnancy-an increasingly common condition?

Chandran Shanthi , Wood Diana , Gurnell Mark , Chatterjee Krish , Wishart Gordon , Simpson Helen

Primary hyperparathyroidism in pregnancy is reported as being rare rare. It can be associated with significant complications. Maternal complications include symptomatic hypercalcaemia, renal calculi, hyperemesis, muscle weakness, and pre-eclampsia. Fetal complications include IUGR, low birth weight, preterm delivery, intrauterine death, neonatal tetany and fits.Patient 1 presented with asthma and was found to have primary hyperparathyroidism, corrected c...

ea0013p223 | AMEND Young Investigator's Award | SFEBES2007

Ectopic ACTH-management difficulties

Yeow Toh-Peng , Balan K , Wood Diana , Gurnell Mark , Chatterjee Krish , Simpson Helen

A 44 yr old IT systems analyst, presented in 2003 with a six month history of weight gain, diabetes and hypertension. On examination he was floridly Cushingoid. Investigations showed raised 9AM cortisol (1887 nmol/l) with failure to suppress following low and high dose dexamethasone, together with elevated 24 h urinary free cortisol (3300 nmol) and circulating ACTH (130 ng/l) levels. CT scan demonstrated a complex 11.5×9 cm lesion in the left lobe of liver and biopsy indi...

ea0086oc3.5 | Reproductive and Neuroendocrinology | SFEBES2022

Radiomics as a tool for risk stratification of non-functioning pituitary adenomas following primary surgery

MacFarlane James , Gillett Daniel , Koulouri Olympia , Bashari Waiel , Casey Ruth , Gurnell Mark

Background: Existing biomarkers have limited ability to discriminate indolent non-functioning pituitary adenomas (NFPAs) from those with a propensity to recur following primary surgery. Radiomics, the extraction of quantitative data from medical imaging, is increasingly recognised as a tool to augment clinical decision making.Methods: 39 patients who underwent primary trans-sphenoidal surgery for an NFPA between January 2007 and April 2017, were enrolled...

ea0086p89 | Neuroendocrinology and Pituitary | SFEBES2022

Somatic sequencing in an enriched cohort of recurrent non-functioning pituitary adenomas

MacFarlane James , Clark Graeme , Rodger Fay , Martin Ezequiel , Allinson Kieren , Gurnell Mark , Casey Ruth

Background: Sporadic non-functioning pituitary adenomas (NFPAs) are described as having quiet mutational landscapes. Genes with recurrent somatic alterations have not been identified by previous studies examining heterogeneous pituitary tumour populations. Existing biomarkers have limited ability to discriminate NFPAs with a predisposition for regrowth from those that will follow a more indolent course after primary surgery. We undertook somatic sequencing, in an enriched coho...

ea0077p95 | Neuroendocrinology and Pituitary | SFEBES2021

Coronary artery bypass grafting (CABG)-related pituitary apoplexy

Serban Laura , MacFarlane James , Senanayake Russell , Stastna Daniela , Mathew Rajeev , Sharma Rishi , Mannion Richard , Gurnell Mark , Bashari Waiel

Background: Pituitary apoplexy is a relatively rare but important clinical syndrome which may be associated with acute headache, visual compromise and hypopituitarism. It can be the initial presentation of a previously unsuspected pituitary macroadenoma. Recognised risk factors include hypertension and the use of antiplatelet agents and/or anticoagulant therapy. It may be life-threatening, requiring emergency endocrine (e.g hydrocortisone) replacement therapy[1] and...

ea0055p32 | Poster Presentations | SFEEU2018

Clinical and biochemical acromegaly associated with a functioning pituitary FSHoma

Huang-Doran Isabel , Koulouri Olympia , Oddy Sue , Halsall David , Allinson Kieren , O'Donovan Dominic , Mannion Richard , Gurnell Mark

Case history: A previously healthy 39 year-old male presented to his optometrist with visual disturbance. Visual field perimetry confirmed bitemporal hemianopia, prompting referral to endocrinology. On questioning, he reported an increase in hand and shoe size, but no headache or diaphoresis. Examination revealed classical acromegaloid features including prognathism, spatulate hands and prominent orbital margins, as well as marked bilateral macro-orchidism.<p class="abstex...

ea0081ep84 | Adrenal and Cardiovascular Endocrinology | ECE2022

The primary aldosteronism rollercoaster: hypoaldosteronism as a potential postoperative complication

Palma August , Hu Lihua , Cheow Heok , Mendichovszky Iosif , Kosmoliaptsis Vasilis , Marker Alison , Bashari Waiel , Senanayake Russell , Gurnell Mark

Introduction: Primary aldosteronism (PA) is a common and potentially reversible cause of secondary hypertension, characterised by resistance to standard antihypertensive therapy and possible hypokalaemia. Lateralisation investigations, including adrenal vein sampling (AVS), are required to distinguish between unilateral or bilateral disease, with unilateral disease representing a potentially surgically curable form of PA. The majority of patients proceeding to adrenalectomy re...

ea0050p291 | Neuroendocrinology and Pituitary | SFEBES2017

Predictors of post-operative hypopituitarism following transsphenoidal surgery

Mulay Akhilesh , Moneim Joe , Keenan Heather , Flynn Rachel , Walsh Sean , Misquita Lauren , Koulouri Olympia , Powlson Andrew S , Gurnell Mark

Background & Aims: The aims of transsphenoidal surgery (restoration/preservation of vision and amelioration of hormonal excess) are balanced against the risk of inducing new post-operative pituitary deficits. This study aims to assess the rate of new anterior hormonal deficits following transsphenoidal pituitary adenoma surgery in our centre and to assess whether the visibility of normal pituitary gland on pre-operative imaging predic...