Searchable abstracts of presentations at key conferences in endocrinology

ea0037oc1.4 | Adrenal 1 | ECE2015

11C-metomidate PET-CT in primary aldosteronism: five possible indications for a non-invasive alternative to adrenal vein sampling

Powlson Andrew S , Koulouri Olympia , Azizan Elena , Maniero Carmela , Taylor Kevin , Aigbirhio Franklin , Koo Brendan , Cheow Heok K , Buscombe John , Gurnell Mark , Brown Morris J

Background: Adrenal vein sampling (AVS) remains the gold-standard for distinguishing unilateral and bilateral disease in primary aldosteronism (PA). However, it is invasive, technically demanding, and may yield inconclusive or equivocal results. 11C-Metomidate PET-CT (11C-MTO-PET-CT) is a non-invasive alternative to AVS for localising unilateral aldosterone-producing adenomas (APAs).Methods/patients: We report a retrospective analys...

ea0037gp.20.08 | Pituitary – Hypopituitarism | ECE2015

‘Pseudo-resistance' in macroprolactinomas treated with dopamine agonists; recognising delayed radiological response and a role for 11C-methionine PET-CT in guiding management

Powlson Andrew S , Koulouri Olympia , Steuwe Andrea , Gillett Daniel , Heard Sarah , Hoole Andrew , Scott Miriam , Challis Benjamin G , Antoun Nagui , Cheow Heok K , Mannion Richard J , Gurnell Mark

Background: Endocrine Society guidelines classify macroprolactinomas as ‘resistant’ if there is failure to normalise prolactin, or to achieve radiological tumour shrinkage of >50%, on standard doses of dopamine agonist. In this context, escalation of treatment to maximal tolerable doses and/or referral for surgery is advised. However, we have recently observed several ‘discordant responders’, where tumour shrinkage lags significantly (>6 months) beh...

ea0037ep89 | Adrenal cortex | ECE2015

Low DHEAS: a sensitive and specific screening test for the detection of subclinical hypercortisolism in adrenal incidentalomas

Dennedy Michael Conall , Anamalai Anand K , Smith Olivia Prankerd , Powlson Andrew S , Graggaber Johann , Shaw Ashley , Halsall David J , Gurnell Mark

Subclinical hypercortisolism (SH) occurs in 5–30% of incidentally-detected adrenal adenomas (AIs). Common screening tests for ACTH-independent hypercortisolism have significant false positive rates, mandating further investigations that are both time and resource intensive. We investigated whether a low basal DHEAS level is a sensitive and specific screening test for the detection/exclusion of SH in patients with newly-diagnosed AI. We recruited 185 consecutive patients w...

ea0034oc6.6 | Clinical | SFEBES2014

11C-methionine PET--CT co-registered with volume MRI: a novel adjunctive imaging modality to aid diagnosis and management in patients with pituitary adenomas

Koulouri Olympia , Kandasamy Narayanan , Powlson Andrew , Moran Carla , Cheow Heok , Antoun Nagui , Levy Miles , Hoole Andrew , Chatterjee Krishna , Donnelly Neil , Mannion Richard , Burnet Neil , Pickard John , Gurnell Mark

Although MRI remains the investigation of choice for pituitary imaging, it does not provide information about ‘functionality’ of lesions (e.g. residual adenoma vs post-surgical scar tissue) and cannot reliably identify all microadenomas.We hypothesised that i) imaging with the PET ligand 11C-methionine, which is taken up at sites of peptide/protein synthesis, would permit more reliable identification of functioning pituitary adenoma ...

ea0031p263 | Pituitary | SFEBES2013

11C-methionine PET–CT co-registered with volume MRI identifies residual functioning tumour in acromegaly

Koulouri Olympia , Kandasamy Narayanan , Moran Carla , Chatterjee Krish , Halsall David , Cheow HK , Antoun Nagui , Hoole Andrew , Burnet Neil , Donnelly Neil , Mannion Richard , Pickard John , Gurnell Mark

Although MRI remains the investigation of choice for pituitary imaging, it does not reliably identify all secretory microadenomas, and cannot always discriminate residual tumour from post-surgical change following hypophysectomy. We hypothesised that i) imaging with the PET ligand 11C-methionine, which is taken up at sites of peptide/protein synthesis, would permit more reliable identification of functioning pituitary adenoma, and ii) co-registration of PET–CT ...

ea0021p204 | Endocrine tumours and neoplasia | SFEBES2009

Temozolomide-induced regression of hepatic metastases in a pituitary corticotroph carcinoma with low O6-methylguanine-DNA methyltransferase expression

Burton Hannah , Annamalai Anand K , Dean Andrew , Kovacs Kalman , Antoun Nagui , Kirollos Ramez W , Simpson Helen L , Jeffries Sarah J , Burnet Neil G , Gurnell Mark

Background: Pituitary carcinoma occurs in ~0.2% of resected pituitary tumours, and carries a poor prognosis (mean survival <4 years), with standard chemotherapeutic regimens showing limited efficacy. However, recent evidence suggests that temozolomide, an orally active alkylating agent used principally in the management of glioblastoma, may also be effective in controlling aggressive/invasive pituitary adenomas/carcinomas. Low levels of expression of the DNA-repair enzyme ...

ea0015p152 | Diabetes, metabolism and cardiovascular | SFEBES2008

Weight gain, on the background of human PPARγ haploinsufficiency, exposes a metabolic phenotype

Mitchell Catherine , Al-Ali Nadia , Savage David , Simpson Helen , Luan Jian'an , Semple Robert , Agostini Maura , Wareham Nicholas , Gurnell Mark , O'Rahilly Stephen , Chatterjee V Krishna

Peroxisome proliferator activated receptor gamma (PPARγ), a ligand-inducible transcription factor, is essential for adipocyte differentiation and lipogenesis. We previously described a kindred in which some individuals were heterozygous for a frameshift/premature stop mutation, (A553ΔAAAiT)fs.185(stop186) in PPARγ, with the truncated protein being non-functional and lacking dominant negative activity1. PPARγ null heterozygotes had norm...

ea0086oc3.1 | Reproductive and Neuroendocrinology | SFEBES2022

Depot somatostatin receptor ligand therapy reverses tissue thyrotoxicosis in thyrotropinomas and aids microadenoma localization via 11C-Methionine PET

Koulouri Olympia , MacFarlane James , Bashari Waiel , Gillett Daniel , Senanayake Russell , Halsall David , Oddy Sue , Powlson Andrew , Serban Laura , Moran Carla , Schoenmakers Nadia , Chatterjee Krishna , Gurnell Mark

Context: Surgery is the first-line treatment option for thyrotropinomas, but medical therapy with somatostatin receptor ligands (SRL) may be used as neoadjuvant treatment and to facilitate safe surgery.Objectives: To determine the extent to which neoadjuvant SRL (i) corrects clinical, laboratory and tissue hyperthyroidism in thyrotropinomas, (ii) induces tumour shrinkage in macroadenomas, and (iii) aids microadenoma detection by 11C-methionine...

ea0051p060 | Pituitary and growth | BSPED2017

A novel IGSF1 mutation in a large Irish kindred highlights the need for family screening in the IGSF1 deficiency syndrome

Roche Edna , McGowan Anne , Koulouri Olympia , Turgeon Marc-Olivier , Nicholas Adeline K , Heffernan Emmeline , El-Khairi Ranna , Lyons Greta , Persani Luca , Dattani Mehul T , Gurnell Mark , Bernard Daniel J , Schoenmakers Nadia

Introduction: Loss-of-function mutations in IGSF1 result in X-linked congenital central hypothyroidism (CeCH), occurring in isolation or in association with additional pituitary hormone deficits. Intrafamilial penetrance is highly variable and a minority of heterozygous females are also affected. We identified and characterized a novel IGSF1 mutation and investigated its associated phenotypes in a large Irish kindred.Methods/Design: A novel, hem...

ea0050oc2.3 | Clinical Highlights | SFEBES2017

A novel IGSF1 mutation in a large Irish kindred highlights the need for systematic familial endocrine screening in the IGSF1 deficiency syndrome

McGowan Anne , Roche Edna , Koulouri Olympia , Turgeon Marc-Olivier , Nicholas Adeline K , Heffernan Emmeline , El-Khairi Ranna , Lyons Greta , Persani Luca , Dattani Mehul T , Gurnell Mark , Bernard Daniel J , Schoenmakers Nadia

Background: Loss-of-function mutations in IGSF1 result in X-linked congenital central hypothyroidism (CeCH), occurring in isolation or in association with additional pituitary hormone deficits. Intrafamilial penetrance is highly variable and a minority of heterozygous females are also affected. We identified and characterized a novel IGSF1 mutation and investigated its associated phenotypes in a large Irish kindred.Methods: A novel, hem...