Searchable abstracts of presentations at key conferences in endocrinology

ea0007p139 | Growth and development | BES2004

Transdermal testosterone application: pharmacokinetics and effects on pubertal status, short-term growth and bone turnover

Ahmed S , Mayo A , Macintyre H , Wallace A

Aim - To assess the effect of transdermal testosterone (TT) on free testosterone concentrations in saliva and on short-term growth and bone turnover in boys with growth or pubertal delay.Method - Prospective, randomized, cross-over study over 26 weeks with 4 weeks of Run-In, 8 weeks of Treatment I (8 hours/12 hours), 4 weeks of Wash-Out, 8 weeks of Treatment II (8 hours/12 hours) and 4 weeks of final Wash-Out.Main Outcome Measures ...

ea0007p236 | Thyroid | BES2004

Hypothyroidism is less frequent following radioactive iodine treatment for toxic nodular goitre than Graves' disease

Adamali H , Gibney J , McKenna T

Since the thyroid is diffusely active in Graves' disease (GD) but exhibits focal activity in toxic nodular goitre (TNG), we tested the hypothesis that hypothyroidism will occur more frequently following radioactive iodine treatment (RAI), in patients with GD compared to those with TNG. To do this we reviewed the outcome of treatment in 86 patients, age 49.7 plus/minus 1.5 years (mean plus/minus SEM), with GD, and 77 patients, age 62.7 plus/minus 1.3 years, with TNG, followed o...

ea0007p246 | Thyroid | BES2004

Electrocardiographic changes in patients with hypothyroidism

Agarwal S , Hira H , Sibal L

Introduction:Hypothyroidism may be associated with bradycardia, low voltage complexes,ST-T wave changes, atrioventricular and intraventricular conduction disturbances. Extrasystoles and tachyarrhythmias of both atrial and ventricular origins have been described in hypothyroidism with the ventricular tachyarrhythmias associated with prolonged QT interval.Aims: To ascertain the prevalence of cardiac arrhythmias in primary hypothyroidism.<p class="abste...

ea0007p261 | Clinical case reports | BES2004

Hypothalamic cavernous haemangioma presenting with hypothalamic syndrome and secondary hypogonadism

Downward H , Rowmanowski C , Bennet W

A 42 year-old man presented in 1994 with a two-week history of headaches, drowsiness and confusion. There had been reduced libido and weight gain for 2 years. There was testicular atrophy and morbid obesity, but no neurological abnormality. CT scan showed a large, partially calcified, suprasellar tumour extending up into the third ventricle. Downward displacement of the posterior clinoid was identified with features of haemorrhage peripherally. MRI scan showed tumour of mixed ...

ea0007p263 | Clinical case reports | BES2004

A case of the pituitary resistance to thyroid hormone successfully treated with bromocriptine

Zieleniewski W , Kolodziej-Maciejewska H , Krawczyk Z

Pituitary resistance to thyroid hormone is a very rare cause of hyperthyroidism. It is characterized by normal, or elevated TSH concentration with high concentration of thyroxine and triiodothyronine.Here, we present a case of a 24-year-old woman who suffered from mild thyrotoxicosis and diffuse goiter for ten years. For several years she was under treatment with methimazole, but without any significant improvement, apart from the enlargement of the thyr...

ea0007p301 | Clinical case reports | BES2004

Complete right vocal cord paralysis: a very rare complication of radioiodine therapy for hyperthyroidism

Beshyah S , Al-Fallouji H , Neave F

INTRODUCTION: The main local complications of radioiodine are transient sore thoart and dysphagia and less commonly hoarseness of voice. Laryngeal palsy is extremely rare. We describe a case of right complete laryngeal paralysis complicating a radioiodine therapy for thyrotoxicosis. CASE STUDY: A 73 year old man who suffers from Graves' disease, mild stable Graves' ophthalmopathy and recurrent hyperthyroidism received a second dose of Radioiodine (15 MiliCuries). He presented ...

ea0007p302 | Clinical case reports | BES2004

Radiotherapy is more effective than growth hormone in treating haemangiopericytoma induced hypoglycaemia

Soran H , Joseph F , Younis N , Scott A

Introduction: haemangiopericytoma is a rare soft tissue tumour originating from pericytes and manifest rarely as hypoglycaemia that can be difficult to treat. We report a case of haemangiopericytoma induced hypoglycaemia treated successfully with radiotherapy.Case report: A 72-year-old lady presented with an episode of confusion. She had had similar episodes usually in the early morning hours. She had had a large bladder haemangiopericytoma removed surgi...

ea0006oc14 | Reproduction | SFE2003

Expression and signaling characteristics of orexin receptors in the human male reproductive system

Karteris E , Chen J , Randeva H

Orexins (A & B) are derived from a common 130 amino acid precursor peptide, prepro-orexin, by proteolytic cleavage, and orchestrate their actions by binding and activating two types of G-protein coupled receptors, orexin-1 receptor (OX1R) and orexin-2 receptor (OX2R). The OX1R preferentially binds orexin-A, whilst OX2R binds both orexin-A and ?B, with similar affinity. Besides playing a role in the regulation of feeding and energy homeostasis, orexins appear to increase se...

ea0006oc17 | Growth and Development | SFE2003

BONE MORPHOGENETIC PROTEIN-2 - RECEPTOR EXPRESSION AND FUNCTION IN PITUITARY GONADOTROPHS

Sidhu K , Stoddart H , Burrin J

The local expression of bone morphogenetic protein-2 (BMP-2) during pituitary development mediates the commitment of undifferentiated cells to the gonadotroph lineage. In the current study, we have used alphaT3-1 and LbetaT2 cells, which represent different stages of gonadotroph development to examine BMP-2 receptor (BMPR) expression and effects of BMP-2 on cell signalling pathways and cell proliferation. In bone, signal transduction via BMPRs requires heteromeric complexing b...

ea0005s25 | Prolactin: Novel Aspects | BES2003

Prolactin receptor expression and prolactin-mediated effects in adipose tissue

Billig H , Svensson L , Ling C

Today prolactin (PRL) has been demonstrated to regulate more then 300 different biological functions, including metabolism during lactation and in subjects with hyperprolactinemia. However, the mechanisms for how PRL regulates the adipose tissue in humans and rodents have remained unclear. We recently reported PRL receptor (PRLR) expression in the adipose tissue of lactating and in PRL-transgenic mice. These results suggest PRLR-mediated effects in adipose tissue. However, to ...