Endocrine Abstracts

Introduction: Long-standing type 2 diabetes (DM) is associated with brain atrophy. In this prospective study we examined the impact of glycaemic status on total brain volume in an elderly cohort.Methods/Design: Two-year follow-up study of a population-derived cohort of non-demented community-dwelling adults aged 70–90 years (Sydney Memory and Aging Study). Prospective MRI and metabolic data were available in 312 of the 542 participants who had a MRI...

Introduction: The molecular basis of exocytosis of secretory insulin-containing granules (SGs) during biphasic glucose-stimulated insulin secretion (GSIS) of pancreatic β-cells remains unclear. Syntaxins (Syns) Syn-1A and Syn-4 are t-SNARE proteins situated on the plasma membrane that have been well studied to mediate insulin exocytosis. However, Syn-3, peculiarly more abundant in insulin SGs, has unclear function in GSIS.Methods/Designs: Confocal m...

Objective: Skeletal disability pathogenesis is multifactorial. Many studies have proved a negative relation of smoking on calcium-phosphate metabolisms, bone density and quality; however in some other papers these results have not been confirmed. The aim of the study was to monitor the influence of the length of smoking, a number of cigarettes smoked and the age of the first use of cigarettes on the whole-body bone density.Methods: Whole-body densitometr...

Introduction: The prevalence of impaired fasting glucose (IFG) in the elderly approaches 50% in some community-dwelling cohorts. We examined whether IFG is associated with a higher burden of disease, cardiovascular risk factors and circulating low-grade inflammation than in normoglycemic elderly people.Methods/Design: Cross-sectional data of 929 participants of the Sydney Memory and Aging Study (MAS) were examined. MAS is a population-derived cohort of c...

Probucol is a traditional anti-hyperlipidemic agent harboring marked antioxidant activity. While probucol is highly hydrophobic, its succinic acid ester, succinobucol, was reported as a water-soluble derivative and was in clinical trials. Succinobucol was shown to be more potent in lipid-lowering, anti-inflammatory and anti-atherogenic effects than probucol in animal models. In addition, succinobucol reduced HbA1c in diabetic patients. Although the clinical trials finally ende...

Introduction: Aim is to determine vitamin D level in patients with Type 2 DM and to evaluate the relationship between vitamin D level and glycemic control.Methods: We evaluated 107 women and 63 male patients with Type 2 DM whose mean age was 55±0.81. Patients fasting blood glucose (FBG), postprandial blood glucose (PPBG), HbA1c and 25(OH)D3 level were measured. The cases were divided into three groups according to measured 25(OH)D3 level (Vitamin D ...

The purpose of the present study was to elucidate expressions of ERβ1 and ERβ2 expression in papillary thyroid cancer (PTC). ER β splicing variants expressions were examined on formalin-fixed, paraffin-embedded thyroid tissues from 106 PTCs and 30 nodular thyroid goiters (NTGs) by immunehistochemical methods using Elivision plus two-step system. There was significant difference in the subcellular localization of ERβ1 expression (P<0.001), but not...

The metabolic features of Polycystic ovary syndrome (PCOS) can vary based on the definition used. The aim of this study is to compare the metabolic characteristics of PCOS according to the phenotypes from various diagnostic criteria and help to establish a optimal diagnostic criteria.Subjects with PCOS defined by the NIH criteria (n=494) and the Rotterdam criteria (n=568) and regular cycling non-hirsuite control women (n=1000) were r...

Insulin resistance is one of the common features of the polycystic ovary syndrome (PCOS), and recent studies indicate the possible role of vitamin D in the pathogenesis of insulin resistance and inflammatory response. We aimed to investigate the association between 25-hydroxyvitamin D (25(OH)D) and insulin resistance and inflammatory marker in obese women with PCOS and controls.We recruited 50 obese women with PCOS (age 25±5 years, BMI 27.5±2.3...

Rapid correction of chronic hyponatremia can cause osmotic demyelination syndrome(ODS). Recent days, vasopressin receptor antagonists(VAs) are clinically used for the treatment of congestive heart failure or hyponatremia including SIADH. To date, few cases of ODS caused by VAs have reported; however, it is presumed that the treatment with VAs for severe hyponatremia may be associated with an increased risk of ODS. Therefore, in this study, we investigated whether rapid correct...