Searchable abstracts of presentations at key conferences in endocrinology

ea0011p390 | Diabetes, metabolism and cardiovascular | ECE2006

Association among individual deprivation using the EPICES score and anthropometric factors linked to abdominal and metabolic markers

Bihan H , Nguyen G , Cohen R , Menu C , Soufi K , Reach G , LeClésiau H

The medical burden of deprived patients is high. In diabetes deprivation status is associated with poor metabolic control and more frequent complications. No data to date existed showing the association between individual deprivation in adults and anthropomorphic factors linked to abdominal obesity. We would determine whether individual index of deprivation were associated with anthropomorphometric dimensions, postures or body girths and metabolic parameters. We conducted a cr...

ea0011p482 | Endocrine tumours and neoplasia | ECE2006

48 h appears as sufficient duration of fasting in the diagnosis of insulinoma – a single centre experience with 23 cases

Quinkler M , Strehlow F , Biering H , Pirlich M , Gerl H , Strasburger CJ , Ventz M

Insulinoma causes fasting hypoglycemia due to inappropriate insulin secretion. The diagnosis of insulinoma is based on Whipple’s triad (1. symptoms precipitated by fasting with 2. associated blood sugars of 50 mg/dl or less and 3. relief of symptoms by glucose administration) during a supervised 72 h fasting test. After introducing reliable assays for measurement of insulin and proinsulin, there is an ongoing debate whether a 48 h fasting test is sufficient for diagnosis ...

ea0011p834 | Thyroid | ECE2006

An audit of radioiodine treatment for thyrotoxicosis in Cambridge

Andreou H , Kalavalapalli S , Gurnell M , Simpson H , Wood DF , Balan KK , Chatterjee VKK

Radioiodine (RAI) is widely used for the treatment of thyrotoxicosis. The efficacy and hypothyroidism rate following a single dose of RAI is variable and the optimum administered dose – sufficient to achieve remission but with an acceptable low hypothyroidism rate, is still debated.Our audit sought to compare the results of local practice with published rates of success and hypothyroidism following RAI. We also examined the relationship between trea...

ea0009p121 | Endocrine tumours and neoplasia | BES2005

Absence of specific effect of DHEA-S deficiency on mood and quality of life in Addisons disease

Adma P , Heald A , Kane J , Gibson C , Davis J , Buckler H , Fowler H

Clinic based studies have shown that patients with Addison's disease have relatively high rates of depression and anxiety symptoms compared with population-based reference samples. Addison's disease results in deficiency of dehydroepiandrosterone (DHEA) and DHEA-sulphate in addition to glucocorticoids and mineralocorticoids. DHEA is thought to have beneficial effects on energy level and mood, independent of circulating testosterone levels. Thus there may be a direct link betwe...

ea0009p133 | Steroids | BES2005

Modulation of glucocorticoid sensitivity by retroviral gene transfer

Le Rouzic P , Gillingham H , Berry A , Garside H , White A , Ray D

Glucocorticoid sensitivity is dependent on the intracellular concentration of the glucocorticoid receptor (GR). GR expression is regulated in a complex, cell-type specific manner, but in most cell types the GR is subject to negative autoregulation by glucocorticoid exposure. Many human diseases are associated with reduced tissue sensitivity to glucocorticoids, including inflammatory arthritis, asthma, and chronic obstructive pulmonary disease. Therefore there is interest in ap...

ea0009p149 | Thyroid | BES2005

Thyroid hormone (T3) activates GH/IGF-1 signalling during skeletal development

O'Shea P , Sriskantharajah S , Yao H , Suzuki H , Cheng S , Chassande O , Samarut J , Williams G

T3, GH and IGF-1 are essential for skeletal development. GH acts directly on growth plate chondrocytes and also via a local paracrine pathway involving IGF-1, but it is unclear whether T3 stimulates bone formation directly or indirectly. To address this, we determined expression of GH-receptor, IGF-1 and IGF-1 receptor (IGF-1R) by in situ hybridisation and activation of downstream STAT5 and AKT signalling by immunohistochemistry in growth plates from four T3-receptor (TR) muta...

ea0007p142 | Growth and development | BES2004

Regulation of the growth hormone (GH) and insulin-like growth factor-1 (IGF-1) paracrine pathway by thyroid hormone (T3) during bone development

Sriskantharajah S , O'Shea P , Yao H , Suzuki H , Cheng S , Williams G

T3, GH and IGF-1 are essential for skeletal development, growth and bone mineralisation. The major growth-promoting actions of GH occur in epiphyseal chondrocytes via direct effects on GH-receptor expressing cells and via a local paracrine pathway involving IGF-1. There is controversy regarding whether T3-actions in bone are direct or occur via regulation of GH secretion and action. We examined this in mice with a mutation (PV) targeted to either T3-receptor (TR) beta or alpha...

ea0006p40 | Endocrine tumours and neoplasia | SFE2003

The effect of pegvisomant therapy on plasma levels of matrix metalloproteinases 2, 9 and vascular endothelial growth factor in patients with acromegaly

Paisley A , Randeva H , Parkinson C , Alsafadi H , Roberts M , Monson J , Drake W , Trainer P

Vascular endothelial growth factor (VEGF) is involved in the activation of the matrix metalloproteinase system (MMP) which in turn degrades the extracellular matrix involved in development, morphogenesis and tissue remodelling. Increased activity of MMPs has been implicated in atherosclerosis and cardiovascular disease. This study assessed plasma MMP and VEGF levels in patients with active acromegaly (IGF-I >130%ULN), and on treatment with pegvisomant.<p class="abstext"...

ea0005p208 | Reproduction | BES2003

Pharmacokinetics and tolerability of a new a bioadhesive buccal testosterone tablet in testosterone deficient men

Ross R , Jabbar A , Jones H , Roberts B , Dunkley K , Long A , Levine H , Cullen D

Pharmacokinetics and tolerability of a new a bioadhesive buccal testosterone tablet in testosterone deficient men.RJM Ross, A Jabbar, H Jones, B Roberts, K Dunkley, A Long, H Levine, DR CullenObjectives: A phase I single centre, open label study of the pharmacokinetics and tolerability of a buccal testosterone tablet (COL1621). Design: The study was approved by The South Sheffield Ethics Committee. Twelve testosterone deficient males were treated with the buccal tablet...

ea0005p211 | Reproduction | BES2003

1,25-Dihydroxyvitamin D3 has a direct effect on steroid production from human theca cells

Brain H , Bano G , Brincat M , Galea R , Pellatt L , Nussey S , Mason H

There is evidence from animal studies that 1,25-dihyroxyvitamin D3 (1,25(OH)2D3) is essential for normal reproductive function. Vitamin deficient rats have reduced fertility and VDR null mutant mice demonstrate impaired folliculogenesis. One small uncontrolled study in humans has demonstrated that vitamin D replacement improves menstrual frequency and acne in women with polycystic ovary syndrome (PCOS). We have previously demonstrated that 1,25(OH)2D3 inh...