Searchable abstracts of presentations at key conferences in endocrinology

ea0077se1.1 | (1) | SFEBES2021

Are gonadotrophins more than gonadotrophins?

Huhtaniemi Ilpo

There is a plethora of information about the extragonadal expression of gonadotrophin receptors (R), i.e. for LH/hCG and FSH, many of the studies published in high-profile journals. LHCGR has been found to be expressed in almost all organs of the body, and FSHR is expressed in fat and bone tissues, as well as in multiple malignant tumours. On the basis of these findings it has been proposed that direct gonadotrophin action participat...

ea0077se1.2 | (1) | SFEBES2021

Abstract Unavailable...

ea0077se1.3 | (1) | SFEBES2021

INSL3: a new index of testis function in puberty and aging

Ivell Richard , Anand-Ivell Ravinder

Insulin-like peptide 3 (INSL3) is a peptide hormone secreted exclusively in boys and men by the mature Leydig cells of the testes. It acts through a unique G-protein-coupled receptor, called RXFP2. In the female INSL3 regulates ovarian antral follicle growth. Whereas INSL3 in the male foetus is responsible for the first phase of testicular descent, in the adult it appears to support spermatogenesis and bone health. Importantly, it is...

ea0077oc1.1 | Reproductive and Neuroendocrinology | SFEBES2021

Melanocortin-4 receptor agonism improves sexual brain processing in women with low sexual desire

Thurston Layla , Hunjan Tia , Mills Edouard , Wall Matthew , Ertl Natalie , Phylactou Maria , Muzi Beatrice , Patel Bijal , Alexander Emma , Suladze Sofiya , Modi Manish , Eng Pei , Bassett Paul , Abbara Ali , Goldmeier David , Comninos Alexander , Dhillo Waljit

Hypoactive sexual desire disorder (HSDD) is the most prevalent female sexual health complaint worldwide, affecting 1-in-10 women. It is characterised by a persistent lack of desire for sexual activity and sexual fantasies, causing distress or interpersonal difficulties. Treatment options are limited, however, melanocortin-4 receptor (MC4R) agonists have emerged as a promising therapy for HSDD, through unclear mechanisms. Investigating the pathways involved is crucial for our u...

ea0077oc1.2 | Reproductive and Neuroendocrinology | SFEBES2021

Hyper-phosphorylation of β-catenin at Serine552 correlates with invasion and predicts recurrence of Non-Functioning Pituitary Tumours (NFPTs)

Rai Ashutosh , Yelamanchi Soujanya D. , Radotra Bishan D , Gupta Sunil K , Chhabra Rajesh , Pandey Akhilesh , Korbonits Marta , Gaston-Massuet Carles , Dutta Pinaki

Background: No predictive biomarkers for NFPT recurrence have been identified, apart from Ki67. We employed high-throughput mass spectrometry-based analyses to examine the phosphorylation pattern of different subsets of NFPTs. Methods: Based on histopathological, radiological and surgical features, NFPTs were sub-grouped into three groups: non-invasive (n = 15), invasive (n = 10) and recurrent (n = 5) subtypes. Invasiveness was...

ea0077oc1.3 | Reproductive and Neuroendocrinology | SFEBES2021

Acromegalic cardiomyopathy in pituitary-specific aryl hydrocarbon receptor interacting protein (Aip) gene knockout animals

Mistry Anisha , Funge Gregory , Sebastian Sonia , Aziz Qadeer , Solomou Antonia , Vignola Maria Lillina , Thong Lim Chung , Herincs Maria , Caimari Francisca , Gaston-Massuet Carles , Tinker Andrew , Korbonits Marta

Introduction: Patients with a germline loss-of-function mutation in AIP are predisposed to young-onset GH excess resulting in gigantism or acromegaly. Acromegaly leads to disease-specific cardiomyopathy with biventricular hypertrophy and diastolic dysfunction progressing to fulminant cardiac failure if left untreated, therefore it is vital to have a tractable animal model to investigate the diseaseFindings: Our AipFlox/Flox;<...

ea0077oc1.4 | Reproductive and Neuroendocrinology | SFEBES2021

Intranasal Kisspeptin Administration Stimulates Reproductive Hormone Secretion in Healthy Men

Mills Edouard G , Swedrowska Magda , Thurston Layla , Phylactou Maria , Patel Bijal , Clarke Sophie A , Yang Lisa , Muzi Beatrice , Choudhry Muhammad , Alexander Emma , Abbara Ali , Forbes Ben , Comninos Alexander N , Dhillo Waljit S

Background: Kisspeptin is a critical activator of hypothalamic gonadotrophin-releasing hormone neurons, inducing release of downstream reproductive hormones. Intravenous or subcutaneous kisspeptin administration has been shown to have significant potential to treat reproductive disorders. However, intranasal administration could offer a novel non-invasive delivery route, which would be clinically preferable. We therefore sought to determine the effects of intranasal kisspeptin...

ea0077oc1.5 | Reproductive and Neuroendocrinology | SFEBES2021

Is radiotherapy for pituitary adenoma or craniopharyngioma associated with increased risk of second brain tumour? A long-term multi-centre study of 3,679 patients

Hamblin Ross , Vardon Ashley , Akpalu Josephine , Tampourlou Metaxia , Spiliotis Ioannis , Sbardella Emilia , Lynch Julie , Shankaran Vani , Mavilakandy Akash , Gagliardi Irene , Meade Sara , Hobbs Claire , Levy Miles J , Cameron Alison , Grossman Ashley , Rosaria Ambrosio Maria , Chiara Zatelli Maria , Reddy Narendra , Bradley Karin , Murray Robert D , Pal Aparna , Karavitaki Niki

Background: Current conclusions on risk of second brain tumour following radiotherapy for pituitary adenoma or craniopharyngioma are challenged methodologically by small patient sample size, selection biases or lack of appropriate controls.Objective: To ascertain whether radiotherapy for pituitary adenoma or craniopharyngioma is associated with increased second brain tumour risk, through use of appropriate methodology.Design: Multi...

ea0077oc1.6 | Reproductive and Neuroendocrinology | SFEBES2021

Differential follicle stimulating hormone glycosylation modulates pre-antral follicle growth and survival rates

Johnson Gillian , Onabanjo Caitlan , Bousfield George , Hardy Kate , Jonas Kim

Ovarian ageing is a naturally occurring physiological process, marked by dynamic changes in ovarian function and hormone secretion. A key endocrine regulator of ovarian function is the heterodimeric glycoprotein hormone, follicle stimulating hormone (FSH). FSH is secreted as two glycosylation variants: partially glycosylated FSH (FSH21) and fully glycosylated FSH (FSH24). These variants have different in-vitro activities, with FSH21 more bioactive than FSH24. Interest...

ea0077oc2.1 | Endocrine Cancer and Late Effects | SFEBES2021

Outcomes of surgery and treatment with selective RET TK inhibitor Selpercatinib in children with MEN2 and advanced MTC.

Kurzawinski Tom , Hubbard Jonathan , Abdel Aziz Tarek , Butler Colin , Brain Caroline , Beale Tim , Gaze Mark , Ross Emma , Stoneham Sarah , Hulse Tony , Simpson Kate , Proctor Ian , Cattaneo Elene , Gevers Evelien , Marshall Lynley , Shankar Ananth

Background: Patients with Multiple Endocrine Neoplasia type 2 (MEN2) without previous family history often present late with advanced Medullary Thyroid Cancer (MTC). Surgery is not always curative but RET tyrosine kinase pathway is a potential target for molecular treatment for progressive MTC.Methods: Retrospective review of clinical, genetic, biochemical (calcitonin, CEA) and imaging (US, CT/MRI, Gallium Dotate) data of children with MEN2 who developed...