Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

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ea0077nkm1 | Nikki Kieffer Medal | SFEBES2021

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ea0077ena1 | Endocrine Nurse Award | SFEBES2021

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ea0077ec1.1 | Early Career Prize Lecture Basic Science | SFEBES2021

Gene discovery in neonatal diabetes to uncover the mechanisms regulating human pancreas development

De Franco Elisa , Wakeling Matthew , Owens Nick , Johnson Matthew , Flanagan Sarah , Hattersley Andrew T

Understanding how pancreatic beta-cells develop during human development is essential to advance current protocols aimed at developing insulin-producing beta-cells in vitro and highlight therapeutic targets for diabetes treatment. Identifying the single-gene mutations which result in individuals developing diabetes in the first 6 months of life (a condition called neonatal diabetes) has the potential to give unique insights into the genes regulating human beta-cells w...
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ea0077ec1.2 | Early Career Prize Lecture Basic Science (1) | SFEBES2021

Cardiometabolic disease burden and urine steroid metabolome in benign adrenocortical tumours: a case-control study

Prete Alessandro , Subramanian Anuradhaa , Bancos Irina , Chortis Vasileios , Tsagarakis Stylianos , Lang Katharina , Macech Magdalena , Delivanis Danae A , Pupovac Ivana D , Reimondo Giuseppe , Marina Ljiljana V , Deutschbein Timo , Balomenaki Maria , O’Reilly Michael W , Bednarczuk Tomasz , Zhang Catherine , Dusek Tina , Diamantopoulos Aristidis , Asia Miriam , Kondracka Agnieszka , Li Dingfeng , Masjkur Jimmy R , Quinkler Marcus , Ueland Grethe AE , Dennedy M Conall , Beuschlein Felix , Tabarin Antoine , Fassnacht Martin , Ivovic Miomira , Terzolo Massimo , Kastelan Darko , Young Jr William F , Manolopoulos Konstantinos N , Ambroziak Urszula , Vassiliadi Dimitra A , Taylor Angela E , Sitch Alice J , Nirantharakumar Krishnarajah , Arlt Wiebke

Background: The overwhelming majority of incidentally discovered adrenal tumours are benign adrenocortical adenomas. These can be non-functioning (NFAT) or associated with cortisol excess on a spectrum ranging from rare clinically overt adrenal Cushing’s syndrome (CS) to much more prevalent mild autonomous cortisol secretion (MACS) without signs of CS. The 1mg-overnight dexamethasone suppression test (DST) further differentiates MACS-1 (possible MACS; post-DST cortisol 50...
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ea0077ec1.3 | Clinical Endocrinology Trust Best Abstract Clinical | SFEBES2021

Phase 3 and extension study of modified-release hydrocortisone in the treatment of congenital adrenal hyperplasia

Merke Deborah P , Mallappa Ashwini , Arlt Wiebke , De La Perriere Aude Brac , Hirschberg Angelica Linden , Juul Anders , Newell-Price John D C , Perry Colin Graham , Prete Alessandro , Rees Aled , Reisch Nicole , Stikkelbroeck Monica , Touraine Philippe A , Lewis Alexander , Maltby Kerry , Treasure Peter , Porter John , Ross Richard John M

Background: Patients with congenital adrenal hyperplasia (CAH) due to classic 21-hydroxylase deficiency have poor health outcomes. We compared disease control in CAH adults treated with modified release hydrocortisone (MRHC, Chronocort®, Diurnal Ltd) versus standard glucocorticoid (GC).Methods: 6-month, Phase 3 study in 122 patients randomised to either MRHC twice daily or standard GC followed by safety extension study on MRHC. Patients had 24-hr 17...
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ea0077ec1.4 | Clinical Endocrinology Trust Best Abstract Basic | SFEBES2021

The vagal Calcium Sensing Receptor mediates the effect of protein ingestion on insulin release and regulates macronutrient metabolism

Norton Mariana , Roberts Anna , Alonso Aldara Martin , Cao Ye , Gribble Fiona , Reimann Frank , Chang Wenhan , Salem Victoria , Murphy Kevin G

Protein stimulates insulin release and improves post-prandial glycaemic excursions. The underlying mechanism has previously been attributed to gastric emptying, incretin release and direct pancreatic stimulation. However, our studies suggest the calcium sensing receptor (CaSR) in the vagus nerve plays an important role. The CaSR has a well characterised role in calcium homeostasis, but also acts as a protein metabolite sensor. In response to the amino acid products of protein ...
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ea0077s1.1 | Lifestyle hacks for metabolic disease | SFEBES2021

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ea0077s1.2 | Lifestyle hacks for metabolic disease | SFEBES2021

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ea0077s1.3 | Lifestyle hacks for metabolic disease | SFEBES2021

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ea0077s2.1 | Nuclear receptors in male reproduction | SFEBES2021

Liver X Receptors (LXR)s and testicular function

Jarvis Sheba , Gethings Lee , Gadaleta Raffaella , Leach Damien , Claude Emmanuelle , Moschetta Antonio , Winston Robert , Williamson Catherine , Bevan Charlotte

Liver X receptors (LXRs) are are ligand-dependent transcription factors, members of the nuclear receptor superfamily of transcription factors. In humans two LXR isoforms exist, LXRα (NR1H3) and LXRβ (NR1H2). LXRα is expressed predominantly in metabolically active tissues, while LXRβ is expressed in the majority of tissues. They have long been known to have critical roles in regulation of lipid metabolism, particu...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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