Endocrine Abstracts

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Key learning points• Adrenocortical tumors comprise frequent benign adenomas and rare aggressive carcinomas (ACC).• cAMP/PKA pathway plays a central role in the pathogenesis of cortisol-producing adenomas - associated with Cushing syndrome, while molecular alterations in Wnt/β-catenin, Rb/p53 pathway and chromatin remodeling are frequent in ACCs.<p class="a...

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Pituitary tumour apoplexy is a condition that occurs as a result of acute haemorrhage and/or infarction within a pituitary tumour (most commonly non-functioning pituitary adenoma), which may or may not be previously known. The clinical presentation occurs within a few hours or days and is due to sudden expansion of the pituitary gland. Manifestations cover a wide range including very intense and frequently retro-orbital...

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We live in a world where neurosurgeons still prescribe salt tablets and fludrocortisone for hyponatraemia, and think cerebral salt wasting syndrome happens on a weekly basis. Neurosurgeons clearly need help, and the world of endocrinology needs to stage an interventionPituitary surgery is almost exclusively based in tertiary referral centres where neurosurgical departments are sited, often with en...

Abnormal uterine bleeding (AUB) is a debilitating symptom that affects up to one in three women at some point in their reproductive lives. It may result in anaemia that necessitates blood transfusion and has a significant negative impact on quality of life. In addition, AUB has a detrimental economic impact on those who experience it, health services and the wider economy. A number of medical treatment options for AUB are curre...