Endocrine Abstracts

Introduction: Disturbances of the thyroid gland are the most common diseases of the endocrine system. Their prevalence is increasing with age and can be easily under diagnosed. Advanced forms of thyroid disease can mimic cardiovascular, psychiatric disorders, malignancy or other disorders and can result in life threatening conditions.Case reports: In the current study we present two case reports concerning patients with cardiovascular symptoms. In both p...

Indroduction: Amiodaron is an potent antiarrhythmic drug used for the treatment of ventricular and supraventricular arrhythmias. Long-term amiodaron therapy can cause a thyroid abnormalities in up to 14–18% patients. There are two main forms of AIT: type 1, a form of iodine-induced hyperthyroidism, and type 2, a drug-induced destructive thyroiditis. Differentiation of these 2 types is essential for determining the best management of the disease.Case...

Objective: Craving of sweet foods and sucrose may be a big obstacle for glycemic control of diabetic patients. It is generally believed that diabetic patients may prefer sweet taste. However, few studies have examined sucrose preference in diabetic patients. Therefore, we investigated changes in sucrose preference in diabetic condition.Research design and methods: We performed two-alternative staircase methods and forced-choice tracking procedures to ass...

Objective: The objective of this study was to determine level of non-HDL and LDL cholesterol in type 2 diabetic patients with or without coronary artery disease irrespective on lipid lowering therapy and the common factors associated with elevated non-HDL cholesterol.Study design: cross-sectional study: Place and duration of study: diabetic clinic, Aga Khan University Hospital, Karachi. Data of Type 2 diabetes mellitus patients attended clinics during 20...

We report on a patient whose type 2 diabetes resolved following interferon-α (IFN-α) therapy for hepatitis C virus (HCV). A 57-years-old man, presented with fatigue, polyuria and polydipsia. He was newly diagnosed with type 2 diabetes. During the hospital day, he was also diagnosed with chronic hepatitis. Serological studies for chronic hepatitis demonstrated presence of hepatitis C, type 2a/2c genotype. He was started on subcutaneous insulin and IFN-α. After 24...

Introduction: More than 50 years after its introducing in 1957 (1996 in USA), metformin is used today in more than 90 countries. It is the most efficient, safe and costless anti-hyperglycemic agent in the treatment of type 2 diabetes mellitus. Its principal risk remains metformin-associated lactic acidosis (MALA), subject of controversies as reported in a recent Cochrane database review in 2010.Patients and methods: We present personal series of all case...

Objectives: Pointing out all the problems and challenges that the medical staff encounters in the management of the patients with a terminal malignant disease with co-existing diabetes mellitus.Methods: Medical documentation, laboratory results, US (Ultra Sound) etc.Results: The study included patients hospitalized in the Gerontology Institute - Hospice “Sue Ryder”-Skopje, with a capacity of 75 beds, in the period of 2009...

Tc- 99m Sestamibi parathyroid scan (SP scan) is performed to identify location of either hyperplastic or adenomatous gland(s) in primary hyperparathyroidism (HPT). In this study we evaluated diagnostic outcome in 55 consecutive patients with clinical diagnosis of HPT who were referred for SP scans and subsequently had parathyroid surgery. These patients with HPT were of 66.9+12.46 (mean + SD) age, and had serum calcium 10.9+0.93 mg/dl, phosphorus 3.0+0.51 mg/dl, chloride 107+3...

Objective: To research the frequencies of HPRL, HI and CAH in PCOS, as well deducing their significance.Material and methods: For five years, 96 patients and their clinical histories were examined by the author, as each patient was visited.HI was proven by 3 h OGGT, testing glucose and insulin simultaneously, ovarian ultrasonography, testosterone, androstenedione, DHEA, 17-hydoxyprogesterone, PRL and LH/FSH were also investigated.<...

Objective: This work sets forth the current status and perspectives of HRT.Material and methods: In total, 547 medical works dealing with this subject are evaluated.Results: The beneficial effect of estrogens on the lipids, as well as the antagonistic influence of progestogens, have long been known.After MWS, HERS and WHI, the beneficial effects on several organs – the arterial system included – hav...