Searchable abstracts of presentations at key conferences in endocrinology

ea0022s3.3 | Bone cell biology | ECE2010

The role of the hypothalamic–pituitary–thyroid axis in bone

Bassett J H Duncan

Disruption of the HPT-axis during growth profoundly influences skeletal development and effects may not be reversed fully following correction of thyroid status. Adult thyrotoxicosis leads to increased bone turnover and is an established risk factor for osteoporotic fracture. The conventional view that skeletal responses to abnormal thyroid status result solely from altered T3 action in bone has, however, been questioned by studies proposing TSH as a negative regula...

ea0019p24 | Clinical practice/governance and case reports | SFEBES2009

All that glitters (on a bone scan) is not cancer

George J , Moisey R

Introduction: Malignancies and hyperparathyroidism account for over 90% of cases of hypercalcaemia. When presenting with suppressed PTH, malignancy is its commonest cause. We present a case of PTH-independent hypercalcaemia of immobilisation responding to bisphosphonate therapy.Case summary: A 57-year-old Caucasian male presented with significant weight loss and severe back pain. He consumed 50 units of alcohol a week, had stopped smoking 20 years earlie...

ea0019p258 | Pituitary | SFEBES2009

Growth hormone replacement and its effect on muscle strength in GH-deficient adults: a meta-analysis

Widdowson WM , Gibney J

A recently published meta-analysis has demonstrated a significant beneficial effect on exercise performance of growth hormone (GH) replacement in GH-deficient (GHD) adults. The current meta-analysis was carried out to determine whether GH replacement confers a similar improvement in muscle strength in this patient group. A medline search and examination of reference lists of included studies and relevant review articles identified five studies with utilizable, robust data, inv...

ea0019p393 | Thyroid | SFEBES2009

Acute changes in thyroid function during treatment with sorafenib, a tyrosine kinase inhibitor

Thomas M , Ahlquist J

Sunitinib and sorafenib are orally active tyrosine kinase inhibitors which have recently been developed as therapy for renal cell cancer and gastro-intestinal stromal tumours. Changes in thyroid function are frequently found during sunitinib therapy, typically occurring 7–24 months into therapy; the mechanism is not clear, though inhibition of iodine uptake, thyroid follicular cell apoptosis and thyroiditis have all been proposed. In contrast, thyroid dysfunction is repor...

ea0017oc11 | Diabetes 1 | BSPED2008

The influence of paediatric diabetic specialist nurses (PDSN) on glycaemic control (HbA1c) in children with Type 1 diabetes in Wales

O'Hagan M , Harvey J

Introduction: Satisfactory glycaemic control in children and teenagers with Type 1 diabetes is difficult to achieve. In Wales before 2002 the level of glycaemic control across the Principality in this age group was unknown.Aims: To determine the level of glycaemic control in diabetic children across Wales.To determine if glycaemic control improved from 2002 to 2007.To identify factors that might be responsibl...

ea0017oc13 | Diabetes 1 | BSPED2008

Children with Type 1 diabetes should be screened for lipid abnormalities at annual review

Howard S , Allgrove J

Background: Hypercholesterolaemia has been identified as a major risk factor for cardiovascular disease in adults with Diabetes Mellitus (DM), and studies have shown evidence of raised lipid levels in children with Diabetes. However, current NICE guidelines state that ‘Routine screening for elevated blood lipid levels is not recommended for children and young people with type 1 diabetes’; although ISPAD and APEG recommendations are for lipid screening in those over 1...

ea0017p15 | (1) | BSPED2008

BSPED audit of patient choice in GH therapy

Kirk J , Langham S

There is now evidence that patient choice in GH device not only improves adherence with GH therapy, but in addition is associated with improved height velocity (Kapoor et al. 2008). In order to find out how common free patient choice is for those commencing GH therapy, and how choice is provided, a questionnaire was sent to all members of the BSPED.A total of 38 questionnaires were received, including from 19 Health Services Human Growth Hormone C...

ea0017p54 | (1) | BSPED2008

Seasonality of disease onset and of birth in type 1 diabetes mellitus

Bandhakavi M , Kirk J

Background: It is recognised that the incidence of type 1 diabetes mellitus (T1DM) is increasing in the United Kingdom, especially in young patients (<5 y). Although seasonal variation in the onset of T1DM, with autumn and winter peaks, and also in the month of birth has been described, it was our perception that new patients were presenting throughout the year to our unit.Methods: Data was available on 440 newly diagnosed cases of TIDM, (100, 173 an...

ea0016s3.2 | Gene/environment interactions in autoimmune endocrine disease | ECE2008

Genome-wide association studies and hormone-dependent cancers

Hunter David J

The cataloguing of human genes and determination of common genetic variation in the human genome presents the major challenge of determining how inherited genetic variation affects our health. Epidemiologists are responsible for assessing the proportion of specific diseases associated with particular genotypes, and how these genotypes interact with environmental and lifestyle factors in disease causation. The advent of the capacity to perform Genome-Wide Association Studies ha...