Searchable abstracts of presentations at key conferences in endocrinology

ea0013p237 | Neuroendocrinology and behaviour (including pituitary) | SFEBES2007

A putative role for 11β-Hydroxysteroid dehydrogenase 1 in the regulation of cerebrospinal fluid dynamics

Sinclair Alexandra , Onyimba Claire , Khosla Pamela , Tomlinson Jeremy , Burdon Michael , Murray Philip , Stewart Paul , Walker Elizabeth , Rauz Saaeha

The pre-receptor regulation of glucocorticoids is mediated by 11β-hydroxysteroid dehydrogenases (11β-HSD). The type 1 isoform is primarily responsible for the generation of active cortisol in tissues such as liver and adipose, whereas 11β-HSD2 regulates sodium and ion transport. Recently, we have shown the presence of functional 11β-HSD1 in the ciliary body of the eye where it is important in control of sodium transport, aqueous humour production and intrao...

ea0013p288 | Steroids | SFEBES2007

Glucose-6-phosphate disposal and regulation of 11β-hydroxysteroid Dehydrogenase type 1: A new link between cellular glucose metabolism and the HPA axis

Ahmed Adeeba , Lavery Gareth , Tomlinson Jeremy , Cooper Mark , Chou Janice , McKiernan Patrick , Elias Elwyn , Walker Elizabeth , Stewart Paul

Microsomal glucose-6-phosphatase (G6Pase) and glucose-6-phosphate transporter (G6PT) are key enzymes in regulation of blood glucose concentration. Deficiency of G6Pase gives rise to glycogen storage disease type Ia (GSDIa) whilst mutations in G6PT cause GSDIb. Both are characterized by growth retardation, hypoglycemia, hepatomegaly, nephromegaly. G6Pase shares its substrate (G6P) with hexose-6-phosphate-dehydrogenase (H6PDH), an ER enzyme functionally coupled with, and which c...

ea0074ncc9 | Highlighted Cases | SFENCC2021

A rare case of Hypocalcaemia – A diagnostic dilemma

Abeyaratne Dayakshi , Healy Ultan , Naziat Auditi , Tomlinson Jeremy , Pal Aparna , Hannan Fadil , Thakker Rajesh , Shine Brian , Jafar-Mohammadi Bahram

Case history: A 38-year-old woman presented with blepharospasm, cramping of the hands, and paraesthesia primarily affecting the face and hands. Symptoms had been present for 10 years but had been progressive over the previous 12 months. Symptoms were consistent with neuromuscular instability. Hypocalcaemia and elevated Parathyroid hormone (PTH) were confirmed. Past medical history was notable for anorexia nervosa in remission. Family history was non-contributary. Hypocalcaemia...

ea0099p219 | Adrenal and Cardiovascular Endocrinology | ECE2024

11β-hydroxysteroid dehydrogenase type 1 inhibition unmasks multiple pathways that may mitigate the adverse effects of prescribed prednisolone

Pofi Riccardo , Coll Sergi , Othonos Nantia , Miller Hamish , Potter Tom , Escott Jane , Whittaker Andrew , Monfort Nuria , Ventura Rosa , Tomlinson Jeremy

Background: Prednisolone is the most commonly prescribed exogenous glucocorticoid(GC) and its use is frequently associated with the development of iatrogenic Cushing’s Syndrome. Once administered, prednisolone is rapidly converted to inactive prednisone by renal 11β-hydroxysteroid dehydrogenase type 2(11β-HSD2) and subsequently reactivated by 11β-HSD1. We have shown previously that 11β-HSD1 inhibition(with the selective 11β-HSD1 inhibitor, AZD4017...

ea0099p92 | Endocrine-Related Cancer | ECE2024

How well does ‘real world’ management of Immune check point inhibitor induced hypophysits (ICI-Hp) reflect the European Society of Endocrinology (ESE) 2023 clinical practice guidelines (CPG)?: Experience from a single tertiary care centre

Mathara Diddhenipothage Shani Apsara Dilrukshi , Warden Jacqui , Herbert Katie , Pofi Riccardo , Coupe Nicholas , Payne Miranda , Tomlinson Jeremy W , Turner Helen

Introduction: Hypophysitis (Hp) is a serious adverse effect (AE) of Immune check-point inhibitor (ICI) therapy in malignancy. We evaluated 6 yeas of clinical expereince with ICI against the recent ESE CPG 2023 which provides practical guidance on the management of this condition based on up-to-date evidence.Methods: A quality improvement project (QIP) included all patients with ICI-Hp (n=17) referred to a dedicated Endocrine-ICI clinic (January ...

ea0050oc4.6 | Adrenal and Steroids | SFEBES2017

Distinct patterns of glucocorticoid metabolism in patients with HNF1A-MODY have the potential to confer a beneficial metabolic phenotype

Juszczak Agata , Gilligan Lorna C. , Hughes Beverly A. , Hassan-Smith Zaki K. , Arlt Wiebke , McCarthy Mark I. , Tomlinson Jeremy W. , Owen Katharine R.

Background and aims: HNF1A-MODY causes monogenic diabetes with a lean, insulin sensitive phenotype. Altered glucocorticoid (GC) metabolism has been implicated in the pathogenesis of type 2 diabetes (T2D) and inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) which regenerates active cortisol from inactive cortisone have been trialled as a therapeutic approach. 11β-HSD1 is down-regulated in hepatocytes from Hnf1a knock-out mice but the role...

ea0050p315 | Obesity and Metabolism | SFEBES2017

Advanced NAFLD is common in bariatric surgical patients, poorly staged by non-invasive NAFLD biomarkers and is associated with adverse outcome

Dempster Niall , Gerogiannis Ioannis , Franklin Rachel , Watson Michael , Rickers Lisa , Fletcher Caroline , Jenkins Eleanor , Sgromo Bruno , Gillies Richard , Cobbold Jeremy , Rosenberg William , Hodson Leanne , Tomlinson Jeremy , Ryan John

Introduction: Non-Alcoholic Fatty Liver Disease (NAFLD) is reported to be common in patients undergoing bariatric surgery, but the diagnostic accuracy of non-invasive NAFLD biomarkers to stage disease and track progress longitudinally has not been assessed.Methods: 274 patients undergoing bariatric surgery were included in the study. Intra-operative liver biopsies were taken from 163 patients and histologically graded using t...

ea0050p320 | Obesity and Metabolism | SFEBES2017

Androgen excess is highly prevalent in women with idiopathic intracranial hypertension and is biochemically distinct from polycystic ovary syndromes

O'Reilly Michael , Hornby Catherine , Westgate Connar , Botfield Hannah , Markey Keira , Mitchell James , Jenkinson Carl , Gilligan Lorna , Sherlock Mark , Gibney James , Tomlinson Jeremy , Arlt Wiebke , Sinclair Alexandra

Idiopathic intracranial hypertension (IIH) is a condition of unknown aetiology characterised by raised intracranial pressure, chronic headaches and blindness. Akin to polycystic ovary syndrome (PCOS), IIH patients are almost exclusively obese females of reproductive age. A distinct androgen excess profile has been noted in PCOS. Here, we aimed to delineate androgen metabolism in IIH compared to PCOS and simple obesity.Women w...

ea0050oc4.6 | Adrenal and Steroids | SFEBES2017

Distinct patterns of glucocorticoid metabolism in patients with HNF1A-MODY have the potential to confer a beneficial metabolic phenotype

Juszczak Agata , Gilligan Lorna C. , Hughes Beverly A. , Hassan-Smith Zaki K. , Arlt Wiebke , McCarthy Mark I. , Tomlinson Jeremy W. , Owen Katharine R.

Background and aims: HNF1A-MODY causes monogenic diabetes with a lean, insulin sensitive phenotype. Altered glucocorticoid (GC) metabolism has been implicated in the pathogenesis of type 2 diabetes (T2D) and inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) which regenerates active cortisol from inactive cortisone have been trialled as a therapeutic approach. 11β-HSD1 is down-regulated in hepatocytes from Hnf1a knock-out mice but the role...

ea0050p315 | Obesity and Metabolism | SFEBES2017

Advanced NAFLD is common in bariatric surgical patients, poorly staged by non-invasive NAFLD biomarkers and is associated with adverse outcome

Dempster Niall , Gerogiannis Ioannis , Franklin Rachel , Watson Michael , Rickers Lisa , Fletcher Caroline , Jenkins Eleanor , Sgromo Bruno , Gillies Richard , Cobbold Jeremy , Rosenberg William , Hodson Leanne , Tomlinson Jeremy , Ryan John

Introduction: Non-Alcoholic Fatty Liver Disease (NAFLD) is reported to be common in patients undergoing bariatric surgery, but the diagnostic accuracy of non-invasive NAFLD biomarkers to stage disease and track progress longitudinally has not been assessed.Methods: 274 patients undergoing bariatric surgery were included in the study. Intra-operative liver biopsies were taken from 163 patients and histologically graded using t...