Searchable abstracts of presentations at key conferences in endocrinology

ea0070ep477 | Thyroid | ECE2020

Thyrotoxicosis and Tuberculosis (TB) related cervical lymphadenopathies: A case report

Almeida Lucia , Sousa Ana , Melo Gustavo , Ramalho Diogo , Correia Sara , Alves Helena , João Oliveira Maria

Introduction: Grave´s disease (GD) is the most prevalent cause of hyperthyroidism, leading to inflammation of the thyroid gland and sometimes to an enlargement of the nearest lymph nodes caused by that same inflammatory process. Peripheral lymphadenopathy of doubtful cause presents a diagnostic dilemma. There are many potential causes: biopsy is sometimes the best way to reach a definitive diagnosis. Tuberculous adenitis is usually regional and mainly affects nodes of the...

ea0033p59 | (1) | BSPED2013

Screening log data can be used to inform protocol modifications, increasing patient recrutiment to a challanging clinical trial

Blair Jo , Awoyale Lola , Thornborough Keith , Peak Matthew , Didi Mohammed , Bedson Emma , Hughes Dyfrig , Ridyard Colin , Tat Tri , Gregory John

Background: Delivery of clinical trials to time and target is critical for studies to be financially viable and relevant. Feasibility studies are informative. However, protocol acceptability and recruitment rates can only be accurately ascertained once a study is open.The SCIPI study (SubCutaneous Insulin: Pumps or Injections?), randomises patients to treatment with multiple daily injections (MDI) or pumps at diagnosis of type I diabetes (TID). A consent...

ea0033p72 | (1) | BSPED2013

Assessment of cortisol and thyroid hormone levels in neonates with myelomeningocele

Soni Astha , Beech Gail , Blair Jo , Didi Mohammed , Das Urmi , Dharmaraj Poonam , Burn Sasha , Buxton Neil , Mallucci Conor , Benedetta Pettorini

Background: GH deficiency has been reported widely in association with myelomeningocele and other pituitary hormone deficiencies occur less frequently. Following an episode of adrenal crisis in a newborn infant with myelomeningocele and multiple pituitary hormone deficiencies we introduced a policy of screening affected, newborn infants for pituitary insufficiency, focusing on thyroid function and cortisol levels.Patients and methods: Data from 26 infant...

ea0028p216 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2012

Severe Acute Mountain Sickness and Brain Natriuretic Peptide in Humans

Stacey Mike , Mellor Adrian , Boos Christopher , Smith Chris , Hooper Tim , Jo Yarker , Hodkinson Pete , Green Nic , Woods David

We have previously reported that exercise at high altitude (HA) led to a significant increase in brain natriuretic peptide (BNP) levels. In contrast two other publications have reported no change in resting BNP at HA. We therefore measured BNP and Lake Louise (LL) Acute Mountain Sickness (AMS) scores in a further 20 subjects at rest in Kathmandu (Kat; 1300 m); and following exercise and at rest at 4270 m and 5150 m. Compared with the baseline BNP level at Kat (9.2+/−2 pg...

ea0027p39 | (1) | BSPED2011

Treatment strategies and outcomes of paediatric Craniopharyngioma since 2005: a single centre experience

Upadrasta Swathi , Doss Arun , Mallucci Conor , Pizer Barry , Abernethy Laurence , Das Urmi , Dharmiaj Poonam , Didi Mohamed , Blair Jo

Background: The Craniopharyngioma service in our centre has changed since 2005 with a standardised preoperative assessment and a new approach to surgery and use of radiotherapy. We review the subsequent outcomes.Treatment strategy: Preoperative endocrinology: prior to dexamethasone therapy: standard dose short synacthen test (SST), thyroid function test (TFT), IGF1, LH, FSH, testosterone/oestradiol±GH stimulation test. Staging: MRI and tumour stagin...

ea0045oc9.1 | Oral Communications 9- Nurses | BSPED2016

A review of junior doctors’ knowledge of the management of newborn disorders of sexual development

Alsaffar Hussain , Turner Lucy , Odedun Rebecca , Giri Dinesh , Edwards Zoe , Blair Jo , Kenny Simon , Senniappan Senthil , McAndrew Fiona , Das Urmi

Introduction: Disorders of sexual development (DSDs) are estimated to occur in 1 in 4500 births. This potentially represents one baby born every other day in the UK. We aim to explore how Mersey foundation and paediatric trainees deal with newborn babies with possible DSD and identify if there is a need for further training in this subject.Methods: An online survey composed of 10 questions was distributed amongst foundation and paediatric trainees in Mer...

ea0073aep176 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

COVID-19 and diabetes: Impact on emergency department demand by diabetic patients. experience from a portuguese center

Maria João Ferreira , Pedro Jorge , José Luis Castedo , Pereira Fernando , Carvalho Davide , Tiago Guimarães

IntroductionCOVID-19 is an emerging disease caused by the new coronavirus (SARS-CoV-2) that has overburdened healthcare worldwide. In Portugal, schedule appointments were cancelled, postponed or changed to tele-consultation. The objective of the study is to assess the impact of the pandemic on the use of Emergency Department (ED) by diabetic patients.Material and methodsRetrospective monocentric study of the ...

ea0073aep430 | General Endocrinology | ECE2021

Sulfamethoxazole/Trimethoprim associated hypoglycaemia in a patient with renal transplantation history

Lavrador Mariana , Catarino Diana , Cátia Andreia Araújo , Luísa Barros , Paiva Isabel

BackgroundAlthough rare, hypoglycaemia in patients without history of diabetes should be recognized and studied, in order to reduce associated morbidity. Cotrimoxazole (TMP/SMX) is commonly used in clinical practice and hypoglycaemia is a rare side effect associated with its use. Literature advocates that this effect is due to the fact that SMX has the same sulphanilamide structural group of sulfonylurea, mimicking the hypoglycaemic effect by stimulating...

ea0073ep178 | Reproductive and Developmental Endocrinology | ECE2021

Precocious puberty: two siblings, two diagnosis

Maria João Ferreira , Moita Rita , Ferreira Sofia , Costa Carla , Santos Silva Rita , Cíntia Castro-Correia

8-year-old girl is referred to a Pediatric Endocrinologist for the appearance of thelarche, first noted at 6.5 years. She had a relevant clinical history of a neonatal meningitis, requiring prolonged hospitalization and the need for ventriculoperitoneal shunt. On physical examination, she had breast development and dark, coarse pubic hair compatible with Tanner stage 3. She weighed 32.3 kg (percentile – Pc- 75–90), her height was 128 cm (Pc 50) and her annual growth ...

ea0073ep209 | Thyroid | ECE2021

Differentiated thyroid carcinoma with metastatic presentation

Almeida Lucia , Almeida Ferreira Marta , Sousa Ana , Alves Helena , Ramalho Diogo , Correia Sara , Maria João Oliveira

IntroductionFollicular thyroid carcinoma (FTC) has metastasis in 10-15%; papillary thyroid carcinoma (PTC) rarely metastasizes. Bone metastasis are rare and can cause pain, fractures and spinal cord compression.Case-172 year-old male referred to the hospital with lower back pain. Imaging examination revealed lytic lumbar lesions. Thoracic-abdominal-pelvic-CT showed trachea compression by a multinodular right ...