Searchable abstracts of presentations at key conferences in endocrinology

ea0014p63 | (1) | ECE2007

Does screening of primary hyperaldosteronism only lead to diagnosis of more adrenal hyperplasia?

Sigurjonsdottir Helga , Gronowitz Mikael , Anderson Ove , Eggertsen Robert , Herlitz Hans , Johannsson Gudmundur

Background: The prevalence of primary hyperaldosteronism (PA) has recently been reported as high as 7.5% in patients with hypertension from unselected populations (USP) and up to 22% in selected populations (SP). Whether increased screening and diagnosis of PA will lead to more findings of curable PA (aldosterone producing adenoma, APA) is unclear.Methods: Three-hundred fifty-three consecutive patients with hypertension, age 20 to 88 years were included ...

ea0056gp2 | Acromegaly | ECE2018

Retinal vessel abnormalities in acromegaly

Fuchtbauer Laila , Olsson Daniel S , Norrman Lise-Lott , Bengtsson Bengt-AEke , Hellstrom Ann , Johannsson Gudmundur

Growth hormone (GH) and insulin like growth factor 1 (IGF-I) modulate and stimulate angiogenesis and endothelial function. Excess of GH, as in acromegaly, is associated with cardiovascular morbidity and mortality, which is reversible after normalization of IGF-I and GH. Diabetes mellitus (DM) is a common comorbidity in acromegaly, but the prevalence of diabetes retinopathy in patients with acromegaly is unknown. Also, the roles of GH and IGF-I in diabetes retinopathy are not f...

ea0056p67 | Adrenal cortex (to include Cushing's) | ECE2018

Adrenal venous sampling in patients with ACTH-independent Cushing’s syndrome

Papakokkinou Eleni , Jakobsson Hugo , Sakinis Augustinas , Muth Andreas , Wangberg Bo , Ehn Olof , Johannsson Gudmundur , Ragnarsson Oskar

Background: ACTH-independent Cushing syndrome (CS) accounts for 15–20% of endogenous CS. Approximately 10% of these patients have bilateral adrenal lesions where the differential diagnoses are primary bilateral adrenal macronodular hyperplasia (PBMAH), primary pigmented nodular adrenal disease (PPNAD), bilateral cortisol producing adenomas or a unilateral cortisol producing adenoma with a contralateral nonfunctioning adenoma. Also, the prevalence of subclinical CS is high...

ea0056p908 | Endocrine Nursing | ECE2018

Patient perspectives on sexuality in hypopituitarism

Bjorkman Ida , Persson Jenny Tiberg , Ung Eva Jakobsson , Olofsson Ann-Charlotte , Johannsson Gudmundur , Dellenborg Lisen

Aim: The aim of the study was to explore patient perspectives on sexuality in hypopituitarism.Background: Hypopituitarism usually leads to a complete loss of sex hormones and the condition has a negative impact on sexuality. Previous research has mainly focused on erectile functioning in men and fertility issues in women but little is known about their sexual wellbeing and experiences of hypopituitarism in relation to sexuality.Des...

ea0073aep39 | Adrenal and Cardiovascular Endocrinology | ECE2021

Increasing incidence of primary aldosteronism – yet an underdiagnosed disorder

Gkaniatsa Eleftheria , Ekerstad Eva , Gavric Emanuela , Trimpou Penelope , Olsson Daniel S. , Johannsson Gudmundur , Ragnarsson Oskar

ContextPrimary aldosteronism (PA) is the most common cause of secondary hypertension. Yet, the incidence of PA in the population has not been studied.ObjectiveTo estimate the incidence of PA in western Sweden.Design and methodsPatients who had received a diagnostic code for PA between 1987 and 2016 were identified in the Swedish National Patient Registry. Assessme...

ea0081rc4.6 | Rapid Communications 4: Pituitary and Neuroendocrinology 1 | ECE2022

Impact of diabetes on morbidity and mortality in patients with acromegaly

Esposito Daniela , Olsson Daniel S , Franzen Stefan , Gudbjornsdottir Soffia , Miftaraj Mervete , Natman Jonatan , Svensson Ann-Marie , Johannsson Gudmundur

Background: Diabetes is an important risk factor for cardiovascular morbidity and mortality but its impact on outcome in acromegaly is unknown.Methods: This was a nationwide, observational, matched-cohort study. Adult patients with acromegaly due to a pituitary adenoma were identified in the Swedish National Patient Registry between 1987 and 2020 and those with coexistent type 2 diabetes in the National Diabetes Registry and Drug Registry. Overall mortal...

ea0063gp53 | Acromegaly and GH | ECE2019

Efficacy and safety of once-weekly somapacitan in adult growth hormone deficiency (AGHD) confirmed in a 53-week REAL-1 trial extension

Johannsson Gudmundur , Gordon Murray , Rasmussen Michael Hojby , Hakonsson Ida Holme , Svaerke Claus , Tahara Shigeyuki , Takano Koji , Biller Beverly MK

Background: Following the 34-week, double-blind, placebo-controlled main phase of REAL-1 (NCT02229851), this open-label trial extension evaluated efficacy and safety of somapacitan in patients aged 23–79 years with AGHD, for an additional 52 weeks (8 weeks’ dose titration followed by 44 weeks’ fixed dose treatment; 86 weeks’ treatment in total).Methods: Patients completing the main trial entered the extension: 1) somapacitan-treated p...

ea0063gp157 | Cushing's | ECE2019

DNA Methylation and fMRI responses in patients with Cushing’s syndrome in remission – suggestions of a functional link between hypercortisolism and neurocognitive dysfunction

Glad Camilla , Andersson-Assarsson Johanna , Stomby Andreas , Dahlqvist Per , Nyberg Lars , Bergthorsdottir Ragnhildur , Johannsson Gudmundur , Ragnarsson Oskar

Introduction: Compared with healthy controls, women with Cushing’s syndrome (CS) in long-term remission have reduced functional brain responses during episodic and working memory testing and decreased overall levels of DNA methylation in blood cells. Here, we sought to test the hypothesis that functional brain responses in the prefrontal cortex and hippocampus are related to epigenetic changes in subjects with CS in long-term remission.Methods: In t...

ea0041oc13.3 | Pituitary Clinical | ECE2016

Increased glucocorticoid replacement doses are associated with excess mortality in patients with non-functioning pituitary adenoma

Hammarstrand Casper , Hallen Tobias , Andersson Eva , Skoglund Thomas , Nilsson Anna G , Ragnarsson Oskar , Johannsson Gudmundur , Olsson Daniel S

Background: Patients with secondary adrenal insufficiency have an excess mortality. Data concerning the influence of the glucocorticoid replacement regime on mortality is sparse.Objective: To investigate if the total daily dose of glucocorticoid replacement has an effect on mortality in patients with non-functioning pituitary adenoma (NFPA).Method: Patients with NFPA treated for hypopituitarism in the western region of Sweden were ...

ea0014p245 | (1) | ECE2007

Growth hormone Reduces Inflammation in Postmenopausal Women with Abdominal Obesity: a 12-month randomized placebo-controlled trial

Franco Celina , Andersson Björn , Lönn Lars , Bengtsson Bengt-Æke , Svensson Johan , Johannsson Gudmundur

Context: Abdominally obese individuals have relative hyposomatotropism, elevated serum markers of inflammation, and increased risk of cardiovascular disease (CVD).Objective: The aim was to study the effect of GH treatment on serum levels of inflammatory markers and vascular adhesion molecules in postmenopausal women with abdominal obesity.Design: Forty postmenopausal women aged 51–63 yrs with abdominal obesity received GH (0.6...