Searchable abstracts of presentations at key conferences in endocrinology

ea0014s24.3 | Obesity | ECE2007

Adipokines and insulin sensitivity in humans

Fernández-Real José Manuel

Decreased insulin action has been proposed as the common factor that is in the background of the different components of the metabolic syndrome. Insulin resistance is also associated with a chronic activation of the innate immune system. The innate immune system constitutes the first line of body’s defence and it is constituted by different barriers (epithelia, adipose tissue), and different blood and tissue components as macrophages, and neutrophils. Once activated, the ...

ea0070aep551 | General Endocrinology | ECE2020

TNF-α induces hyperpolarization in agrp neurons without affecting pomc neurons of the arcuate nucleus

Chaves Fernanda , Frazao Renata , Donato Junior José

Neurons expressing the agouti-related protein (AgRP) and the pro-opiomelanocortin (POMC) are part of the central system responsible for regulating energy balance and food intake. The hypothalamus is sensitive to changes in the inflammatory state. Either high-grade inflammation (e.g., caused by sepsis) or low-grade inflammation (caused by obesity) disturbs the hypothalamic function via inflammatory cytokines. Understanding how these cytokines interact and regulate the circuits ...

ea0073aep217 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

In the context of acute disease does the same hyperlactatemia cut-off point hold similar meaning in patients with and without Diabetes mellitus? A retrospective study

Inês Vieira , Petrova Maja , José Moura

IntroductionHyperlactatemia is defined by a lactate value > 2 mmol/l and a lactate value above > 4 mmol/l is commonly used to define more severe hyperlactatemia. It is a common disorder in critically ill patients, associated with adverse prognosis. Diabetes mellitus (DM), however, can also be associated with increased lactate levels at baseline.ObjectivesTo document the development of severe hyperlact...

ea0070ep26 | Adrenal and Cardiovascular Endocrinology | ECE2020

Success rate of adrenal vein sampling: A ten-year experience

Martínez Montoro José Ignacio , Damas Fuentes Miguel , Fernández Valero Andrea , Picón César María José , Tinahones Madueño Francisco José

Introduction: Adrenal vein sampling (AVS) is the gold standard test to distinguish between unilateral adenoma and bilateral hyperplasia in primary hyperaldosteronism. This is a technical complicated procedure with a variable success rate. Our aim was to report our 10-year-success rate and results as regards to this procedure.Material and Methods: Retrospective observational study including data from patients undergoing AVS between 2009 and 2019.<p cl...

ea0073aep115 | Calcium and Bone | ECE2021

Transient hypocalcaemia and definitive hypoparathyroidism after total thyroidectomy in Graves’ disease

Bruno Bouça , Amaral Sara , Vasques Miguel , Monteiro Nuno , Crespo Ana , José Coutinho , Tavares Paula , Bogalho Paula , José Silva-Nunes

IntroductionHypocalcaemia is a complication of total thyroidectomy (TT) and may be more frequent in patients with Graves’ disease. The reason for this increased risk is unclear and its occurrence has been associated with: ophthalmopathy severity, preoperative calcaemia and reimplantation of parathyroid glands.ObjectivesTo evaluate the risk factors for transient hypocalcaemia (TH) and definitive hypoparat...

ea0073aep346 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Use and effectiveness of dapagliflozin in type 1 diabetes: Clinical experience data of six months

José Ignacio Martínez Montoro , Andrea Fernández Valero , Fuentes Miguel Damas , José Luis Pinzón Martín , Tinahones Francisco J

IntroductionSodium-glucose cotransporter-2 inhibitors (SGLT2i) are a new class of oral antidiabetic drugs used for the treatment of type 2 diabetes mellitus. Recently, the SGLT2i dapagliflozin was approved for use in type 1 diabetes (T1DM) as an add-on to insulin therapy.Material and methodsWe conducted a retrospective observational study which included demographic and clinical-analytical data from 16 patient...

ea0037gp.13.05 | Diabetes and obesity – Translational cardiovascular and obesity | ECE2015

The effects of cross-sex hormone therapy on body weight and fat percentage in transgender individuals

Klaver Maartje , Vlot Mariska , Dekker Marieke , Megens Jos , Heijer Martin den

Introduction: Cross-sex hormone therapy is part of the treatment of individuals with gender dysphoria and affects several factors such as body composition and thereby cardiovascular risk. However, little is known about the specific effects on body weight and fat percentage in the first year of treatment.Aim: The aim of this study is to examine the effects of cross-sex hormones on body weight and total fat percentage during the first year of treatment.</p...

ea0020p444 | Obesity and Metabolism | ECE2009

Letrozole normalizes serum testosterone and reduces body weight in morbidly obese men with obesity-related hypogonadotropic hypogonadism

Loves Sandra , de Jong Jos , van Sorge Adriaan , Telting Darryl , de Boer Hans

Introduction: Hypogonadotropic hypogonadism is frequently observed in morbidly obese men, due to aromatase-dependent conversion of androgens to estrogens in adipocytes. The clinical impact of this sex hormone imbalance is not known.Aim: To evaluate the clinical effects of aromatase inhibition in obesity-related hypogonadotropic hypogonadism.Methods: Double-blind, placebo-controlled trial for 6 months in severely obese men (BMI &#62...

ea0073aep276 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Heterozygous familial hypercholesterolemia with intolerance to PCSK9 inhibitors

Saraiva Miguel , Palma Pedro , José Alexandre Queirós , Palma Isabel

IntroductionHeterozygous familial hypercholesterolemia is one of the most common genetic disorders and it is associated with an at least ten times higher risk of coronary heart disease. Frequently, it is necessary to medicate the patients with PCSK9 inhibitors (PCSK9i) so they can reach LDL-c target values. In Portugal, the only evolocumab is available and the most commonly reported adverse effects are local pruritus and upper airway symptoms.<p clas...

ea0073aep582 | Reproductive and Developmental Endocrinology | ECE2021

Hyperandrogenism and portosystemic shunt - report of two cases

Manique Inês , Rego Teresa , Fonseca Fernando , Agapito Ana , José Silva-Nunes

IntroductionSevere hyperandrogenism is a warning sign in young women. Differential diagnosis includes neoplastic, non-neoplastic and iatrogenic causes. The association of hyperandrogenism and congenital or acquired portosystemic shunt (PSS) has been rarely described, with its pathophysiology being unclear.Case 1A 22 year-old woman with diagnosis of autoimmune hepatitis, portal hypertension and PSS since 15 ye...