Searchable abstracts of presentations at key conferences in endocrinology

ea0082oc2 | Oral Communications | SFEEU2022

A case of multiple paragangliomas in a chronic hypoxic patient with congenital heart disease

Khanam Amina , Tharma Tharani , Joshi Mamta , Velusamy Anand , Carroll Paul

A 50-year-old female with complex chronic hypoxic congenital heart disease was incidentally identified with a 2 cm extra-vesicular nodule of the bladder during a surveillance ultrasound scan. Suspicious of a bladder carcinoma she uneventfully underwent open partial cystectomy. Histology confirmed a bladder paraganglioma with local lymph node invasion. Post-operative biochemical work-up disclosed raised plasma metanephrine”s: normetadrenaline 7073 pmol/l (120-1180 pmol/l),...

ea0065p139 | Endocrine Neoplasia and Endocrine Consequences of Living with and Beyond Cancer | SFEBES2019

Clinical spectrum of endocrine toxicities of Immune checkpoint therapy: single centre experience

Joshi Mamta , Duffy Leo , Velusamy Anand , Papa Sophie , Carroll Paul

Introduction: Checkpoint inhibitor (CPI) related endocrine toxicities are increasingly commonly with the use of these new cancer agents. With one of the largest cancer departments in UK, we studied the clinical management and outcome of patients who developed different endocrine toxicities over the last five years, with the use of CTLA-4, PD-1 and PDL-1 agents.Methods: All patients treated with CPI between 1 Jan 2014 to 31 Jan 2019 were included for the ...

ea0063p1041 | Interdisciplinary Endocrinology 2 | ECE2019

Identification, management and outcome of endocrine toxicities related to immune checkpoint inhibitors

Duffy Leo , Joshi Mamta , Velusamy Anand , Papa Sophie , Carroll Paul

Introduction: Immunotherapy has become standard treatment for an increasingly wide range of cancers. Checkpoint inhibitors (ICT; CTLA4, PD1 & PD-L-1) can cause endocrine toxicity, principally affecting the pituitary and thyroid glands. We have studied the clinical management and outcome of patients with endocrine adverse effects over 5 years at our cancer centre.Methods: All patients treated with ICT agents between 1 Jan 2014 to 31 Jan 2019 were incl...

ea0063p1042 | Interdisciplinary Endocrinology 2 | ECE2019

Use of Simple Referral system to provide quality care in the management of Endocrine Toxicities with Immune checkpoint therapy: Auditing the effectiveness of a new referral system

Duffy Leo , Joshi Mamta , Velusamy Anand , Papa Sophie , Carroll Paul

Introduction: Immune checkpoint therapies are novel cancer agents, which have been associated with the development of endocrine toxicities. ESMO and SfE endorsed management guidelines have been helpful for the early recognition of these toxicities, but in clinical practice, having early access to specialist endocrine advice improves the decision making and effective use of these agents when toxicities occur. In response to need we developed an easily accessible interdisciplina...

ea0082p20 | Poster Presentations | SFEEU2022

Adrenocortical carcinoma in two young patients

J Tharma Tharani , Khanam Amina , Joshi Mamta , Velusamy Anand , Carroll Paul

The first case is a 19-year-old male who presented to his GP with lumbar pain, scrotal bruising, and weight loss. Abdominal CT showed a left 6.4 cm x 12 cm suprarenal mass; the right adrenal gland was atrophic. Plasma metanephrines and MIBG were normal. Urinary steroid profile (USP) showed raised 11-deoxycortisol, consistent with adrenocortical carcinoma (ACC). He underwent a left nephrectomy and adrenalectomy. Histology confirmed ACC. The lesion was encapsulated with negative...

ea0091wg2 | Workshop G: Disorders of appetite and weight | SFEEU2023

Severe hyperandrogenism due to ovarian hyperthecosis in a young woman

Ahamed Sadiq Shafana , Jeyaka Neha , Maltese Giuseppe , Johri Nikhil , Joshi Mamta , Hyer Steve

Case History: Hyperandrogenism is a relatively common clinical problem. However, severe hyperandrogenism causing virilisation is rare. A 22-year-old lady with no significant past medical history, presented with oligomenorrhoea, hirsutism and male pattern hair loss over last 3 years duration. She has no acne or change in voice or clitoromegaly. She was also noted to be having high BP on clinic visit and grade 1 acanthosis nigricans.Investigations: Her tot...

ea0091p32 | Poster Presentations | SFEEU2023

Non-islet cell tumour hypoglycaemia (NICTH) caused by an intrathoracic tumour and responding well to glucocorticoid therapy

Ahamed Sadiq Shafana , Jeyakar Neha , Maltese Giuseppe , Johri Nikhil , Joshi Mamta , Hyer Steve

Case History: An 81-year-old gentleman was brought to A&E by ambulance after being found to be hypoglycaemic at home by paramedics. His wife reported that he experienced unsteadiness and slurred speech after waking up in the morning and she called the emergency number. On arrival of paramedics, his capillary blood glucose was found to be 1.2 mmol/l and he was administered intravenous dextrose. He also had a couple of similar episodes which were resolved with food. He is no...

ea0062wb1 | Workshop B: Disorders of growth and development | EU2019

Ectopic posterior pituitary syndrome with hypopituitarism and pubertal delay

Howells Lara , Saqib Aaisha , Bakhit Mohamed , Li Adrian , Joshi Mamta , Carroll Paul

A 19 year old Bangladeshi male attended ED with a fractured finger. He was noted to have a severely delayed bone age of 13.5 years, and no facial hair. He had moved to the UK aged 11 and could recall little information regarding his childhood or his parents. He had no significant medical co-morbidities, and in particular no history of mumps, measles or testicular injury. He reported being the shortest in his class, and being unable to keep up with his classmates in physical ac...

ea0046p27 | (1) | UKINETS2016

Modality to detect pancreatic NETS in MEN1: EUS or MRI?

Joshi Mamta , McGowan Barbara , Powrie Jake , Breen Louise , Jacques Audrey , Izatt Louise , Carroll Paul

Background: Pancreatic neuroendocrine tumours (pNETs) are commonly reported in patients with MEN1. The estimated incidence is reported as 40–80% of adults with MEN1 and pNETs are frequently multifocal. Guidelines recommend that CT, MRI and endoscopic ultrasound (EUS) can be used for detection and surveillance of pNETs in MEN1. MRI has been the most commonly used modality, but EUS may be more sensitive in detecting pNETs.Objective: To compare the sen...

ea0044p128 | Neoplasia, cancer and late effects | SFEBES2016

Timing and outcome of surgery for primary hyperparathyroidism in MEN1

Joshi Mamta , McGowan Barbara , Hubbard Johnathan , Powrie Jake , Breen Louise , Jacques Audrey , Izatt Louise , Carroll Paul

Background: There is no consensus on the optimal timing of surgery for primary hyperparathyroidism (PHPT) in MEN1. Experienced centres recommend subtotal or total parathyroid surgery with three and a half gland surgery along with thymic removal as a favoured procedure; but long-term outcomes have rarely been reported.Objective: To investigate the indications and outcomes for surgery in patients with PHPT in MEN1Methods: Review of c...