Endocrine Abstracts

Introduction: Since aggressive pituitary tumors are rare, there are no clear guidelines considering treatment of these tumors. A wide range of treatments have been used, with various success.Case report 1: A 58-year old lady presented with sudden severe headache and ptosis of the left eye. MRI revealed an expansive intrasellar, suprasellar and bilateral parasellar process with extension to the skull base which was inaccessible for neurosurgery. Pituitary...

A 64-year-old lady presented feeling unwell with nausea, vomiting, headaches and dizziness. She was taking sulpiride for schizophrenia and had an 8-year history of hyponatraemia. The hyponatraemia, was associated with mild hyperprolactinaemia, prompting investigation for hypopituitarism twice previously by endocrinologists in a different hospital. Secondary adrenal insufficiency had been excluded on the basis of: cortisol 576 nmol/l at 30 min after 250 mcg synacthen and cortis...

The aim of these two case reports (husband and wife) is to highlight the importance of homeopathic medication on HPA axis.The first case is a 60-year-old Indian lady known to have diabetes mellitus, hypertension and hypercholesterolaemia, who presented with difficulty in losing weight and generalised aches and pains. As part of the investigations by her General Practitioner her serum cortisol was found to be low at 32 mmol/l. Short synacthen test showed ...

This is an unusual case of sleep apnoea treated with C-PAP as a result of multinodular goitre (MNG) which was overlooked.This is a case of a 69-year-old gentleman who was referred to the endocrine clinic for assessment of his diabetes. Sleep apnoea was diagnosed around four years ago and he has been using C-PAP every night. Enlargement of multinodular goitre coincided with the diagnosis of sleep apnoea. He has previously been seen by another endocrinolog...

A 47-year-old lady presented with a long history of resistant hypertension. Her GP referred her for further investigation to a cardiologist who found a smaller right kidney on ultrasound scan and an elevated rennin level. Renal artery MRA revealed right renal artery stenosis. On September 2008, she underwent right renal artery stenting and was advised to stop taking the antihypertensive medications (doxazosin and amlodipine). A week later she was admitted with headache, vomiti...

69-year-old male with background of hypertension and dyslipidaemia was admitted to ENT with a food bolus obstruction. CXR on admission revealed a well-defined mass in the right lower lobe consistent with lung cancer. Oesophagoscopy revealed a narrowing level secondary to external compression. A staging CT of chest and abdomen confirmed a mass on the right base invading the main right lower lobe bronchus. Incidentally there was an 8 cm infra renal abdominal aortic aneurysm. The...

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Graves’ disease typically follows a relapsing and remitting course. Most patients with recurrent hyperthyroidism after withdrawal of antithyroid drugs (ATDs) are offered definitive treatment with radioactive iodine. This retrospective study aimed to identify clinical and biochemical indices that predict relapse following ATD withdrawal, which could allow earlier definitive treatment to be initiated.We studied 70 patients with Graves’ disease wh...

Background: Adiponectin and resistin belong to the group of adipocytokines, that are thought to be involved in regulation of insulin sensitivity, and that also exert the opposite effects on inflammatory processes related to atherosclerosis and cardiovascular risk. Glucocorticoids have anti-inflammatory properties, but also increase insulin resistance. There are, however, conflicting data on the effects of glucocorticoids on serum concentrations of adiponectin and resistin....

Studies show men and women differ in their aptitude towards different cognitive tests, which may be attributable to hormonal differences. It has also been postulated that oestrogen has disease-assuaging properties in some mental illness. The aim of this study was to assess the Cambridge Neuropsychological Test Automated Battery (CANTAB) as a tool for measuring cognitive differences between the sexes.A total of 43 volunteers, 20 women and 22 men, aged bet...