Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1433 | Pituitary Clinical | ICEECE2012

Coexistence of macroprolactinaemia and hyperprolactinaemia in women with oligo-/amenorrhoea is associated with high risk of pituitary adenomas

Gasior-Perczak D. , Lewandowski K. , Kowalska A. , Lewinski A.

Background: The so called ‘big-big’ prolactin, also known as macroprolactin is formed by prolactin-immunoglobulin complexes, is considered to be biologically inactive, but may cause elevation of serum prolactin (Prl) concentrations measured by standard assays. In women presenting with oligo- and/or amenorrhoea the cause of menstrual irregularity needs to be explained even in the setting of concomitant macroprolactinaemia. We have therefore attempted to assess the pre...

ea0029p1527 | Pituitary Clinical | ICEECE2012

Pituitary lesions: Pituitary adenomas and what else?

Vourliotaki I. , Boumpaki A. , Alexaki S. , Stamataki K.

Introduction: Pituitary lesions are quite often in the general population and can be symptomatic or not. Most are attributed to pituitary adenomas. Differential diagnosis also includes other causes, such as granulomatous diseases (sarcoidosis, histiocyttosis). Neurosarcoidosis is rare. Sarcoidosis pituitary infiltration is even more rare and usually reported in multifocal forms of the disease.Case report: We describe a 34-year old female with headache an...

ea0029p1649 | Thyroid (non-cancer) | ICEECE2012

Celiac disease in patients with autoimunne thyroiditis – pilot study

Krcma M. , Balihar K. , Dvorakova E.

Introduction: Benefit of general screening for concomitant autoimunne diseases in patients with chronic autoimunne thyroiditis (AIT) is serious problem from medical, even from economic point of view. Some authors advice for screening, some advert to mass occurence of AIT and warn about huge expenses. Situation vary from one country (region) to another.Aim: To assess incidence of celiac disease in patients with chronic autoimunne thyroiditis and find any ...

ea0029p1684 | Thyroid (non-cancer) | ICEECE2012

A rare case of periodic hypokalaemic paralysis secondary to Graves’ thyrotoxicosis

Wernig F. , Wincup C. , Wynne K.

A 42-year-old gentleman of Ghanaian origin presented with a 1 month history of worsening severe proximal myopathy. On presentation his symptoms had progressed to the extent that he was unable to mobilise from his bed. Prior to this illness he had been fit and well. Examination revealed severe proximal myopathy and a uniformly enlarged, smooth thyroid gland. There was no clinical evidence of hyperthyroidism.Blood tests on admission showed a serum potassiu...

ea0029p1720 | Thyroid (non-cancer) | ICEECE2012

A case of toxic multinoduler goiter coexists in TSH-producing pituitary tumor

Kunii Y. , Noh J. , Mukasa K. , Matsumoto M. , Suzuki M. , Iwaku K. , Ohe H. , Watanabe N. , Sekiya K. , Yoshihara A. , Ito K.

Introduction: The frequency of toxic multinoduler goiter (TMNG) is different among the countries depending on an intake of iodine, but it is said to be ~1% of adenomatous goiter in Japan. In addition, the frequency of TSH-secreting pituitary adenoma (TSHoma) is rare with 0.5–1.0% of pituitary gland tumor. There is no report that TMNG coexists in TSHoma so far.Case: A 58 years old female was complained swelling of thyroid and palpitation. We found se...

ea0029p1741 | Thyroid (non-cancer) | ICEECE2012

Increase of Serum Adiponectin And Stable Concentrations of Matrix Metalloproteinases Confirm Safety of Radioiodine Treatment of Thyrotoxicosis

Lewinski A. , Brona A. , Lewandowski K. , Bienkiewicz M. , Milewicz A.

Background: Matrix metalloproteinases (MMPs), together with their tissue inhibitors (TIMPs), remodel extracellular matrix under physiological and pathological conditions and are implicated in pathogenesis of cardiovascular diseases, cancer and in chronic inflammation. We have endeavoured to assess whether concentrations of MMPs, TIMPs, proinflammtory thrombospondin and anti-inflammatory adiponectin are altered by administration of radioiodine during treatment of thyrotoxicosis...

ea0029p1817 | Thyroid cancer | ICEECE2012

Clinical trial of thyroid RFA for papillary microcarcinomas

Fukunari N. , Nakano M. , Arai K.

The management of papillary thyroid microcarcinomas (PTMC) has been controversial and only observation without surgery has been advocated for the low-risk PTMC. Radio-frequency ablation(RFA)has been applied to thyroid nodule, which shows safe and useful results for benign thyroid nodules. In our institution, not only benign nodules, but thyroid malignancies have been attempted to be therapeutic objectives by RFA. The aim of this study is to evaluate the efficacy of RFA for pri...

ea0028p64 | Clinical practice/governance and case reports | SFEBES2012

Danazol falsely elevates oestradiol levels in a woman with ovarian failure

Devine K , Freel E , Perry C

A 29 year old woman with multiply-relapsed Hodgkin’s lymphoma became amenorrhoeic with vasomotor menopausal symptoms following multiple cycles of chemotherapy. Subsequent biochemistry confirmed primary gonadal failure (LH 30.7 U/L, FSH 49.9 U/L, oestradiol <70 pmol/L). Following allogeneic bone marrow transplantation she developed severe haemolytic anaemia and thrombocytopenia. This was resistant to standard therapies, including methylprednisolone, mycophenolate mofet...

ea0026p14 | Adrenal cortex | ECE2011

Autosomal recessive pseudohypoaldosteronism: a rare cause of life-threatening electrolyte imbalance

Tharian K , Warner J T , Gregory J

A well-term baby born to consanguineous healthy Yemenese parents was observed in the hospital as parents had lost previous three babies (both male and female) within 10 days of age (in Yemen). These babies who were initially well were reported to have developed a rash and then collapsed and died. Post-mortems were not done. This baby who appeared well at birth, also developed a facial rash on day seven and was found to have hyponatremia and severe hyperkalemia, albeit a normal...

ea0026p411 | Thyroid (non cancer) | ECE2011

Thyroid peroxidase antibodies in euthyroid children: is long term follow up required?

Tharian K , Evans C , Warner J T

Introduction: The presence of thyroid peroxidase (TPO) antibodies in euthyroid children poses a potential risk for the development of autoimmune hypothyroidism. Little is known about the ontogeny of this process. This retrospective study aims to estimate the risk of developing hypothyroidism in euthyroid children with raised TPO antibodies and provide a guideline for follow up.Methods: Children 0–16 years with raised TPO antibodies (1996–2005) ...