Searchable abstracts of presentations at key conferences in endocrinology

ea0029p238 | Calcium & Vitamin D metabolism | ICEECE2012

Role of chromogranin-A in the truncation of parathyroid hormone in cultured parathyroid cells from patients of the secondary hyperparathyroidism

Kanai G. , Sawada K.

Introduction: Two major assay systems have been used for evaluation of parathyroid hormone (PTH) secretion. Whole PTH (wPTH) recognizes full-length 84 amino acid residues [PTH(1–84)], and Intact PTH (iPTH) recognizes NH2-truncated forms, such as PTH(7–84), in addition to PTH(1–84). Patients with chronic renal failure have increased amount of PTH(7–84) in circulations, so that the ratio of wPTH/iPTH indicates 0.7 or below usually. On the other hand, chromogr...

ea0029p297 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Effect of triiodothyronine and angiotensin-II on expression of (pro)renin receptor in the human erythroid cell line, YN-1

Nishiyama H. , Kaneko K. , Ohba K. , Yoshioka T. , Shimizu T. , Hirose T. , Totsune K. , Takahashi K.

The renin–angiotensin system is known to enhance erythropoiesis. (Pro)renin receptor ((P)RR), a specific receptor for renin and prorenin, has recently been identified. We have recently shown expression of (P)RR in a human erythroid cell line, YN-1. It is known that triiodothyronine (T3) and angiotensin-II (A-II) stimulate proliferation of erythroid cells. The aim of the present study is to clarify effects of T3 and A-II on expression of (P)RR in the ...

ea0029p442 | Clinical case reports - Thyroid/Others | ICEECE2012

A case of pneumomediastinum and tracheomalasia in thyroid storm with longstanding goiter

Lee K. , Park C.

Tracheomalasia is extremely rare condition in Graves’ disease and may result in pneumomediastium with fistular formation from longstanding compression by a large goiter. There is no report that Graves’ disease combined with tracheomalasia and pneumomediastinum. A 24-year-old woman presented with abdominal pain, diarrhea and fever. On physical examination, a large goiter was detected on her anterior neck. Computed tomography of chest showed large amount of air in ante...

ea0029p490 | Developmental endocrinology | ICEECE2012

Characterization of a mouse model of paediatric combined hormone deficiency

Prince K. , Rhodes S.

To better understand the molecular and cellular nature of paediatric combined pituitary hormone deficiency diseases, our laboratory has recently generated a novel mouse model of the severe paediatric diseases caused by mutations in the LHX3 transcription factor gene. Through gene targeting, we have produced an Lhx3 W227Ter mouse modeling the LHX3 W224Ter (loss of carboxyl terminus) human disease. Patients with the W224Ter mutation are of short stature and ...

ea0029p634 | Diabetes | ICEECE2012

Development of a high-sensitive urinary albumin immunosensor based on MCM-41-PVA nanocomposite and AuNPs

Omidfar K , Gholizadeh F

Accurate and sensitive detection of the biomarkers is important both for preclinical research fields such as biochemistry, biomedicine, and clinical diagnostics. Immunosensors are the miniaturized analytical devices that combine high specificity of immunological reaction with sensitivity of detection techniques.In this study, we developed a new competitive immunosensor with employing antibody (Ab) labeled AuNP (Ab-AuNP) and mobile crystalline material-41...

ea0027s21 | Symposium 3–Insulin Resistance and Type 2 Diabetes: Novel Insights | BSPED2011

Genetic disorders of insulin signalling

Semple Robert K

Driven by the rising global tide of obesity, insulin resistance is already at pandemic levels, and is intimately associated with major pathologies including type 2 diabetes, ovulatory dysfunction and hyperandrogenism, the spectrum of fatty liver disease, and disorders of growth including cancer. Yet despite intensive study of prevalent forms of the condition, major questions remain both about the nature of the genetic predisposition to insulin resistance, and the mechanisms li...

ea0026s19.2 | Management of endocrine disease in adolescence | ECE2011

The challenges of managing childhood cancer survivors during adolescence

Gleeson H K

In the UK 1 in 500 children will develop cancer in childhood. Survival from childhood cancer has more than doubled since the 1960s. Survivorship is increasingly on the agenda and the National Cancer Survivorship Initiative has been launched in the UK.During adolescence the endocrinologist is faced with four challenges in managing childhood cancer survivors:-1. Managing the immediate endocrine consequences of cancer therapy, in part...

ea0026p8 | Adrenal cortex | ECE2011

Validation of the disease-specific quality of life questionnaire AddiQoL in European Addison patients

Oksnes M , Lovas K

Introduction: Patients with Addison’s disease (AD) self-report impairment in specific dimensions on well-being questionnaires. An AD disease-specific quality of life questionnaire (AddiQoL) was developed to aid evaluation of patients. We here aimed to validate translated questionnaires in terms of internal consistency and reliability and to improve the construct of the scale.Methods: After translation by a multistep approach, the final versions were...

ea0024p39 | (1) | BSPED2010

Case series: is thiamine responsive megaloblastic anaemia and diabetes associated with cardiac anomalies

Aswani N , Price K

We describe four cases of Thiamine Responsive Megaloblastic Anaemia (TRMA), Rogers Syndrome. Three cases are siblings, the fourth from another family. They are all of Pakistani origin and born to consanguineous parents. All have the clinical triad of megaloblastic anaemia, non-type 1 diabetes mellitus, and sensorineural deafness.The SLC19A2 gene mutation affects the transport of thiamine, which is required for normal tissue growth and development in huma...

ea0024p48 | (1) | BSPED2010

A rare complication of Hashimoto’s thyroiditis

Kiriella K , Raine J

Primary thyroid gland lymphomas account for less than 5% of all thyroid malignancies. They mainly occur in the setting of lymphocytic thyroiditis or Hashimoto’s disease. The majority are mucosa-associated lymphoid tissue lymphomas and diffuse large B-cell lymphomas. There have not been any cases of thyroid lymphoma reported in children in the last 20 years.Our patient is a 9-year-old boy who was noted to have a lump on the right side of his neck in ...