Endocrine Abstracts

It has been claimed that the use of the TRH test and the nocturnal TSH surge test might uncover the diagnosis of the so-called 'hidden' central hypothyroidism, in a substantial proportion of euthyroid cranially irradiated children. In our study of 37 euthyroid adult cancer survivors and 34 matched normal controls, patients had significantly (P<0.05) higher basal and stimulated TSH levels and a slightly slower TSH decline between 20 and 60 min during the TRH test; none had b...

A 40-year-old woman was admitted for investigation of severe fatigue, abdominal pain, anorexia and myalgia over the preceding year. Past medical history included vitiligo, coeliac disease and depression. Initial investigations revealed hyperkalaemia, normocytic anaemia and hypercalcaemia with an inappropriately normal parathyroid hormone level. Low TSH with normal free T4 and T3 (0.02 milliunits per litre, 17.1 picomoles per litre and 6.3 picomoles per litre respectively) were...

A 25 year old female presented with a two year history of secondary amenorrhoea and expressible galactorrhoea. There was no history of headache or visual disturbance, and the patient took no regular medication. Examination, including formal perimetry, was normal. Investigations revealed a moderately elevated prolactin 1,029 (NR 59-619 mU/ml), 9am cortisol 366 nmol/L, remainder of pituitary profile normal. An MRI pituitary revealed a macroadenoma with stalk deviation and bowing...

Neurokinin B has been traditionally regarded as a neuropeptide being confined to the CNS, with no peripheral expression. This situation was the cause of some confusion as its preferred receptor (NK3R) is found mainly on peripheral organs such as the portal vein, mesenteric vessels and the heart with relatively low levels in the brain. In 2000 our laboratory reported the placenta to be an abundant peripheral endocrine source of NKB, giving rise to significant plasma concentrati...

Abstract for Society for Endocrinology Conference 2003Category: Clinical case report (Young Endocrinologist)AbstractTitle: A CASE OF HYPERTHYROIDISM PRESENTING AS HAEMATOLOGICAL MALIGNANCYAuthors: K.M. Evans, D.E. Flanagan; Dept. of Endocrinology and Diabetes, Derriford Hospital, Plymouth, PL6 8DHA 30 yr old man was referred to the Haematology department with axil...

Proadrenomedullin N-terminal 20 peptide (PAMP) and adrenomedullin are hypotensive peptides that are cleaved from the proadrenomedullin peptide. Adrenomedullin can act via the complex calcitonin receptor like receptor (CRLR) and receptor activity modifying protein (RAMP) 2 or the putative receptor, CRLR/RAMP3 complex. CGRP (Calcitonin gene related peptide) binding is conferred by the CRLR/RAMP1 complex. This study was carried out to see how adrenomedullin and PAMP affected the ...

OBJECTIVE: To evaluate if follow up in a specialty clinic for Diabetics can result in lower LDL levels.METHODS: A Veterans Administration (VA) diabetes clinic established in 1996 consisted of 5 academic endocrinologists, nurse practitioner, endocrinology fellows, rotating medical housestaff, pharmacist, nutritionist and nurse. All patients enrolled in diabetes clinic for at least one year had their electronic medical record reviewed retrospectively for d...

THE REGULATION OF ADRENOMEDULLIN AND PROADRENOMEDULLIN N-TERMINAL 20 PEPTIDE IN THE ADRENAL GLAND: THE DIFFERENCE BETWEEN ADRENOCORTICAL CELLS AND CHROMAFFIN CELLS.Vakharia K, Hinson JP.Department of Endocrinology, Lab 1.2 Dominion House, Queen Mary University of London, London E, UK.It has been established that the adrenomedullin gene is expressed in the adrenal cortex and adrenal medulla, and that both adre...

OBJECTIVE: To evaluate if follow up in a specialty clinic for Diabetics can result in lower LDL levels.METHODS: A Veterans Administration (VA) diabetes clinic established in 1996 consisted of 5 academic endocrinologists, nurse practitioner, endocrinology fellows, rotating medical housestaff, pharmacist, nutritionist and nurse. All patients enrolled in diabetes clinic for at least one year had their electronic medical record reviewed retrospectively for d...

Presentation: A 66 year old woman, was admitted as an emergency with one week history of profound weakness ('had to crawl to the fridge to get milk for tea'), lethargy, productive cough and hypokalaemia (GP results: Na 141, K 1.5, bicarbonate 47 (23-28), Creatinine 54 (μmol/l). Her medication: Amlodipine 5 mg od, Bendrofluazide 2.5 mg od, Aspirin 75 mg.PMH: hypertension, moderate COPD and peripheral vascular disease. She smoked 20 cigarettes a day an...