Searchable abstracts of presentations at key conferences in endocrinology

ea0003p299 | Thyroid | BES2002

Thyroid function in early pregnancy. A prospective study

Bohnet H , Martens K

There is ample evidence that despite an overall improvement of iodine intake, not only in Germany but also in many European countries pregnant woman may be deficient of this trace element.Healthy pregnant women (n=66) without a thyroid history volunteered for an ultrasound scan of the thyroid and for a blood sample; TSH, free T ¾ and TPO - antibodies were measured of the thyroid.21 (32%) of the pregnant women exhibited an ...

ea0002p59 | Growth and development | SFE2001

Effect of birth weight on hypothalamo-pituitary adrenal (HPA) function in postnatal pigs

Poore K , Fowden A

Programming of the HPA axis during prenatal and early postnatal life may explain, in part, the association between low birth weight (BW) and the increased incidence of cardiovascular and metabolic disease in later life. The present study examined the effect of variations in intrauterine growth on HPA axis function, assessed by an insulin-induced hypoglycemic challenge, in 3 and 12 month (m) old pigs.Low BW (<1.5 kg; n=22) and high BW (>1.5 kg; n=25...

ea0054oc1 | (1) | NuclearReceptors2018

Heterodimerization of retinoid X receptor with xenobiotic nuclear receptors occurs in the cytoplasmic compartment of cell in a ligand independent manner

Dash Amit K , Yende Ashutosh S , Tyagi Rakesh K

The ‘Nuclear Receptor (NR) Super-family’ is a group of ligand modulated transcription factors with 48 members presently identified in human genome. NRs regulate most of the physiological processes of the body ranging from metabolism to reproduction. Retinoid X Receptor (RXR) is one of the important members of this NR superfamily. It serves as a heterodimeric partner of several other members of this superfamily including two major xenobiotic nuclear receptors i.e. Pre...

ea0081p502 | Thyroid | ECE2022

Comparing non-diagnostic FNA results in thyroid nodules

K Chandra A , Kumar Vijay , Kumar Manish , K Jha R

Introduction: Multiple specialities teach and perform ultrasound-guided fine-needle aspiration biopsy (USG-FNA) of thyroid nodules, including Radiology, Endocrinology, and Pathology. Contrasts in cytopathology results might connect with various USG-FNA procedures just as contrasts in the knobs assessed. This study planned to play out a nitty-gritty investigation of USG-FNA results among these different showing administrations at a solitary scholarly clinical focus.<p class...

ea0083rdp1 | Reproductive and Developmental Endocrinology | EYES2022

A case of postmenopausal hirsutism

T Peshkova , K Kamashidze , L Jashi , K Dundua

Introduction: Progressive hirsutism and moderate to severe male-pattern balding in women requires exclusion of an adrenal or ovarian tumor.Case presentation: A 51-year-old lady presented with excessive hair on her face and lower abdomen of 1 year duration which affected her quality of life. Her menopause started 3 years ago. Her body mass index was 28.6 kg/m2. She had hair on her upper lip, chin, and lower abdomen; she had a Ferriman–Gall...

ea0041ep891 | Pituitary - Clinical | ECE2016

Non-alcoholic fatty liver disease in patients with biochemically cured Cushing’s disease and non-functioning pituitary adenomas: role of adrenal insufficiency and growth hormone deficiency

Auer Matthias K , Stieg Mareike R , Stalla Gunter K

Objective: Nonalcoholic fatty liver disease (NAFLD) is a hallmark of the metabolic syndrome and has been shown to be an independent predictor of cardiovascular mortality. Although glucocorticoids and growth hormone are known to be implicated in its pathophysiology, it has only rarely been investigated in the context of patients with pituitary insufficiency or former cortisol excess.Design: Case-control study, including patients with biochemically control...

ea0029p508 | Diabetes | ICEECE2012

Influences of the 2011 Tohoku Earthquake on glycemic control in patients with diabetes mellitus in Tokyo

Kumagai N. , Muroya Y. , Shimodaira M. , Tsuzawa K. , Honda K.

Objectives: Huge 9.0 magnitude quake and tsunami attacked eastern areas of Japan, on March 11th 2011. They claimed more than 20,000 lives and destroyed the nuclear power plants. Although the property damage was very little in Tokyo, about 250 miles apart from the epicenter, the people in capital faced a lot of hard situations. For example, unusual food supply, the lack of the daily necessities, the limitation of the electricity supply, and a fear of hundreds of aftershocks and...

ea0029p1211 | Obesity | ICEECE2012

ASP injection promotes macrophage infiltration and M1 polarization in obese adipose tissue

Fisette A. , Oikonomopoulou K. , Munkonda M. , Lambris J. , Cianflone K.

Recent integrative approaches showed that adipose tissue play a major endocrine role. Molecules secreted by the expanding adipose tissue modulate systemic inflammation and contribute heavily to the pathology of obesity co-morbidities. Acylation stimulating protein (ASP) is an adipokine that has been linked with energy metabolism and lipid metabolism. The ASP receptor, C5L2, is widespread within tissues in the organism, yet ASP effects outside the adipose tissue remain explored...

ea0029p1502 | Pituitary Clinical | ICEECE2012

A difficult case of hyponatraemia in a neurosurgical patient

Wernig F , Kaura A , Wynne K , Nair R , Meeran K

A 40-year-old female presented with a 6 week history of right-sided headaches and nausea. She was found to have an Arnold-Chiari malformation and an unusual C3 syrinx on MRI brain scanning. She underwent a foramen magnum decompression and C1 laminectomy. Three weeks later, she was admitted with headaches, nausea and vomiting, and blurring of her vision on left lateral gaze. Whilst in the emergency unit, the patient had a tonic-clonic seizure.Following th...

ea0029p1672 | Thyroid (non-cancer) | ICEECE2012

Serum concentrations of thrombospondin-1 and adiponectin in patients with hyperthyroidism before and after normalisation of thyroid function

Dabrowska K. , Lewandowski K. , Skowronska-Jozwiak E. , Brona A. , Milewicz A. , Lewinski A.

Background: Hyperthyroidism is a common endocrine disorder that is linked to increased cardiovascular morbidity and mortality. Thrombospondin, the matricellular protein, is an important player in the process of cardiac remodelling with complex effects on cardiovascular disease (e.g. prothrombotic and antiangiogenic effects vs potential protective effects in heart failure). Adiponectin is an adipose tissue-derived hormone that shows beneficial effects on atherogenesis, endothel...