Endocrine Abstracts

Introduction: Appropriate replacement therapy of not only gonadotrophins, but other deficient pituitary hormones is important in patients with hypopituitarism for a successful pregnancy. Data regarding GH replacement therapy during pregnancy is limited. We would like to present a case with panhypopituitarism including severe GH deficiency due to Sheehan’s syndrome, who achieved successful pregnancy with GH replacement therapy in the first half of pregnancy.<p class="a...

Objectives: It has been recently recognized that GH may have a role in hematopoiesis and immune system. However, there are conflicting data regarding the effects of GH deficiency (GHD) and/or GH replacement therapy in GH deficient patients on hematopoiesis and immune system. The aim of the present study was to investigate the peripheral blood cell counts, T- and B-lymphocyte subsets and immunoglobulin levels before and after GH replacement therapy in patients with adult onset ...

Objectives: Evaluation of the HPA axis is still a big challenge. This study was performed to compare 1 μg ACTH, 250 μg ACTH and glucagon tests for evaluation of HPA axis in healthy male and female subjects with different ages.Materials and methods: This study was carried out on 57 healthy individuals (29 men, 28 women) between 20 and 70 years of age (the number and gender of the subjects are approximately equal for each decade). Low dose short ...

Introduction: Presence of GH receptor in human skin and its appendages suggests a direct effect of GH on skin characteristics. Wet and oily skin due to hyperhidrosis and increased sebum production were described in acromegaly patients.Objective: The aim of the study was to examine the hydration via capacitance, sebum content, transepidermal water loss, pH and temperature of the skin in patients with acromegaly. The data were compared with that of control...

Objective: Vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor 1 (VEGFR1) are known to be related to thyroid tumorigenesis, but data are limited about their relationship with insulin like growth factor 1 (IGF1) and IGF1 receptor. The aim of this study was to clarify the role of VEGF, VEGFR-1, IGF1 and IGF1 receptor in thyroid tumorigenesis.Methods: We examined 40 patients with differentiated thyroid carcinoma (DTC) a...

Hirsutism, which is characterized by excessive growth of terminal hair in a male pattern, is a common clinical condition in women. Among its etiologies, idiopathic hirsutism (IH) is considered to be one of the most common forms of hirsutism. We have previously shown the presence of insulin resistance in women with IH and our aim was to investigate the effects of metformin therapy in women with IH. The study was approved by the local Ethics Committee. Sixteen women with IH (mea...

Some of the patients with hyperandrogenemia are characterized by regular cycles and normal ovaries on USG and named as idiopathic hyperandrogenemia (IHA). To clarify the pathophysiology of IHA we have investigated both the adrenal and ovarian functions, and insulin resistance in 20 patients with IHA and 10 healthy women. The study was approved by the local Ethics Committee. The patients have at least one increased serum androgen. ACTH stimulation test, buserelin test and an OG...

Objective: Hirsutism, affects between 5% and 10% of women during reproductive age. Hirsutism associated with normal ovulatory function and normal circulating androgen concentrations is defined as idiopathic hirsutism and little information is available regarding the molecular pathogenesis.Aim: Significance of polymorphisms of the genes involved in androgen/oestrogen biosynthesis (SRD5A2,CYP19) and their expressions inmodulating the susceptibility ...

Although the existence of the interaction between sex steroids and immune system is well known, the mechanisms of this interaction are still unclear. Recently a second form of GnRH (GnRH-II) has been described in human, which is significantly expressed in immune tissues suggesting a potential function. In a recent in-vitro study it has been demonstrated that GnRH-II decreases local expression of IL-2R in peripheral lymphocytes (1). However in-vivo interactions of...

Objective: Impaired cognitive function has been demonstrated in adults with GH deficiency (GHD) by using different neuropsychological tests. P300 ERP application is a well established neurophysiological approach in the assessment of cognitive function. Kickboxing is a novel cause of hypopituiatarism due to sports related traumatic brain injury (TBI) and isolated GHD is the most common problem (1).The present preliminary study was therefore designed to in...