Searchable abstracts of presentations at key conferences in endocrinology

ea0035p856 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

GH replacement therapy during pregnancy in a patient with Sheehan's syndrome

Karaca Zuleyha , Tanriverdi Fatih , Uludag Semih Zeki , Ozgun Tuncay , Unluhizarci Kursad , Kelestimur Fahrettin

Introduction: Appropriate replacement therapy of not only gonadotrophins, but other deficient pituitary hormones is important in patients with hypopituitarism for a successful pregnancy. Data regarding GH replacement therapy during pregnancy is limited. We would like to present a case with panhypopituitarism including severe GH deficiency due to Sheehan’s syndrome, who achieved successful pregnancy with GH replacement therapy in the first half of pregnancy.<p class="a...

ea0022p567 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Effects of GH replacement therapy on hematopoiesis and immune function: a placebo controlled study

Cakir Ilkay , Tanriverdi Fatih , Karaca Zuleyha , Kaynar Leylagul , Elbuken Gulsah , Eser Bulent , Unluhizarci Kursad , Kelestimur Fahrettin

Objectives: It has been recently recognized that GH may have a role in hematopoiesis and immune system. However, there are conflicting data regarding the effects of GH deficiency (GHD) and/or GH replacement therapy in GH deficient patients on hematopoiesis and immune system. The aim of the present study was to investigate the peripheral blood cell counts, T- and B-lymphocyte subsets and immunoglobulin levels before and after GH replacement therapy in patients with adult onset ...

ea0022p568 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Comparison of 1 μg ACTH, 250 μg ACTH and glucagon tests for assessment of the hypothalamo-pituitary–adrenal axis in healthy subjects

Tanriverdi Fatih , Lale Ayhan , Karaca Zuleyha , Kula Mustafa , Unluhizarci Kursad , Kelestimur Fahrettin

Objectives: Evaluation of the HPA axis is still a big challenge. This study was performed to compare 1 μg ACTH, 250 μg ACTH and glucagon tests for evaluation of HPA axis in healthy male and female subjects with different ages.Materials and methods: This study was carried out on 57 healthy individuals (29 men, 28 women) between 20 and 70 years of age (the number and gender of the subjects are approximately equal for each decade). Low dose short ...

ea0022p593 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Investigation of skin characteristics in patients with acromegaly

Borlu Murat , Karaca Zuleyha , Yildiz Hatice , Tanriverdi Fatih , Elbuken Gulsah , Unluhizarci Kursad , Kelestimur Fahrettin

Introduction: Presence of GH receptor in human skin and its appendages suggests a direct effect of GH on skin characteristics. Wet and oily skin due to hyperhidrosis and increased sebum production were described in acromegaly patients.Objective: The aim of the study was to examine the hydration via capacitance, sebum content, transepidermal water loss, pH and temperature of the skin in patients with acromegaly. The data were compared with that of control...

ea0022p759 | Thyroid | ECE2010

Expressions of vascular endothelial growth factor (VEGF), VEGF receptor 1 (VEGF1), insulin like growth factor 1 (IGF1) and IGF1 receptor in differentiated thyroid carcinoma

Karaca Zuleyha , Tanriverdi Fatih , Ozturk Figen , Elbuken Gulsah , Cakir Ilkay , Unluhizarci Kursad , Bayram Fahri , Kelestimur Fahrettin

Objective: Vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor 1 (VEGFR1) are known to be related to thyroid tumorigenesis, but data are limited about their relationship with insulin like growth factor 1 (IGF1) and IGF1 receptor. The aim of this study was to clarify the role of VEGF, VEGFR-1, IGF1 and IGF1 receptor in thyroid tumorigenesis.Methods: We examined 40 patients with differentiated thyroid carcinoma (DTC) a...

ea0020p643 | Reproduction | ECE2009

The effects of metformin therapy in women with idiopathic hirsutism

Unluhizarci Kursad , Ahu Baysal Nuran , Karaca Zuleyha , Tanriverdi Fatih , Kelestimur Fahrettin

Hirsutism, which is characterized by excessive growth of terminal hair in a male pattern, is a common clinical condition in women. Among its etiologies, idiopathic hirsutism (IH) is considered to be one of the most common forms of hirsutism. We have previously shown the presence of insulin resistance in women with IH and our aim was to investigate the effects of metformin therapy in women with IH. The study was approved by the local Ethics Committee. Sixteen women with IH (mea...

ea0020p661 | Reproduction | ECE2009

Does idiopathic hyperandrogenemia exist?

Kursad Unluhizarci , Emin Capak Mehmet , Fatih Tanriverdi , Zuleyha Karaca , Fahrettin Kelestimur

Some of the patients with hyperandrogenemia are characterized by regular cycles and normal ovaries on USG and named as idiopathic hyperandrogenemia (IHA). To clarify the pathophysiology of IHA we have investigated both the adrenal and ovarian functions, and insulin resistance in 20 patients with IHA and 10 healthy women. The study was approved by the local Ethics Committee. The patients have at least one increased serum androgen. ACTH stimulation test, buserelin test and an OG...

ea0016p610 | Reproduction | ECE2008

Quantitative determination of aromatase and 5-α reductase mRNA and polymorphisms in the aromatase and 5-α reductase genes in idiopathic hirsutism

Dundar Munis , Okay Caglayan A , Baysal Nuran Ahu , Tanriverdi Fatih , Ozkul Yusuf , Unluhizarci Kursad , Kelestimur Fahrettin

Objective: Hirsutism, affects between 5% and 10% of women during reproductive age. Hirsutism associated with normal ovulatory function and normal circulating androgen concentrations is defined as idiopathic hirsutism and little information is available regarding the molecular pathogenesis.Aim: Significance of polymorphisms of the genes involved in androgen/oestrogen biosynthesis (SRD5A2,CYP19) and their expressions inmodulating the susceptibility ...

ea0014p10 | (1) | ECE2007

Normalization of serum testosterone level alters local GnRH-II and IL-2R mRNA expression in peripheral lymphocytes in patients with idiopathic hypogonadotrophic hypogonadism (IHH)

Tanriverdi Fatih , Akalin Hilal , Caglayan Okay , Demirkoparan Umit , Ozkul Yusuf , Dundar Munis , Bayram Fahri , Kelestimur Fahrettin

Although the existence of the interaction between sex steroids and immune system is well known, the mechanisms of this interaction are still unclear. Recently a second form of GnRH (GnRH-II) has been described in human, which is significantly expressed in immune tissues suggesting a potential function. In a recent in-vitro study it has been demonstrated that GnRH-II decreases local expression of IL-2R in peripheral lymphocytes (1). However in-vivo interactions of...

ea0014p523 | (1) | ECE2007

Evaluation of cognitive functions by using P300 auditory event related potentials (ERPs) in amateur kickboxers: a preliminary study

Tanriverdi Fatih , Yapislar Hande , Suer Cem , Kocyigit Ismail , Unluhizarci Kursad , Kelestimur Fahrettin

Objective: Impaired cognitive function has been demonstrated in adults with GH deficiency (GHD) by using different neuropsychological tests. P300 ERP application is a well established neurophysiological approach in the assessment of cognitive function. Kickboxing is a novel cause of hypopituiatarism due to sports related traumatic brain injury (TBI) and isolated GHD is the most common problem (1).The present preliminary study was therefore designed to in...