Searchable abstracts of presentations at key conferences in endocrinology

ea0070ep522 | Thyroid | ECE2020

Autoimmune polyglandular syndrome type 3

Besrour Chayma , Nacef Ibtissem Ben , Imen Rojbi , Youssef Lakhoua , Nadia Mchirgui , Karima Khiari

Introduction: Autoimmune polyendocrine syndrome ( APS ) is a rare, inherited disorder, characterized by autoimmune thyroiditis with another organ specific autoimmune disease.ObservationWe report the case of 55 years old woman, descendant of a first degree consanguineous marriage, who presented at the age of 35 a premature ovarian insufficiency and alopecia. Eight months later, she developed a goiter with hyperthyroidism and the dia...

ea0022p104 | Bone/Calcium | ECE2010

Wermer syndrome revealed by primary hyperparathyroidism: a case report

Nadia Mchirgui , Ali Insaf Hadj , Karima Khiari , Hela Cheikhrouhou , Youssef Lakhoua , Nejib Ben Abdallah

Multiple endocrine neoplasia type 1 (MEN1) is a rare but misleading disease. The diagnosis is evocated when two main lesions are present (parathyroid, pituitary gland, endocrine pancreas tumor: Gastrinoma). We studied a 36 year-old woman hospitalized in orthopedics for a neck femur fracture. A hypercalcaemia (Ca++=2.84 mmol/l) with elevated PTH=500 pg/ml were discovered before intervention. The bone biopsy concluded to primary hyperparathyroidism lesions.<p class="abstext"...

ea0022p105 | Bone/Calcium | ECE2010

Severe primary hyperparathyroîdism related multiple clear cell adenome

Karima Khiari , Ali Insaf Hadj , Youssef Lakhoua , Nadia Mchirgui , Hela Cheikhrouhou , Abdallah Nejib Ben

We report a 25 years old man who admitted in our department for primary hyperparathyroidism. He has previously been diagnosed with urolithiasis in 2006 and two pathological fracture of the humerus in 2009.Physical exam was normal laboratory findings showed hypercalcemia (4.06 mmol/l) associated to a high parathyroid hormone level (PTH: 1930 pg/ml).Ultrasound examination of the neck showed two enlarged parathyroid adenoma.<p cla...

ea0022p490 | Female reproduction | ECE2010

Spontaneous pregnancy in Sheehan syndrome

Nadia Mchirgui , Insaf Hadj Ali , Karima Khiari , Youssef Lakhoua , Nejib Ben Abdallah

Spontaneous pregnancy in the course of Sheehan syndrome is extremely rare because of gonadotrophic insufficiency, which is almost present.The aim of our study is to analyse cases of pregnancies occurring spontaneously in patients with Sheehan syndrome.It is a retrospective study of 46 women who had a Sheehan syndrome diagnosed in the Internal Medicine and endocrinology department of Charles Nicolle Hospital during the period betwee...

ea0022p491 | Female reproduction | ECE2010

Sheehan syndrome: metabolic and hormonal abnormalities (46 cases)

Insaf Hadj Ali , Emna Haouat , Nadia Mchirgui , Karima Khiari , Youssef Lakhoua , Nejib Ben Abdallah

Sheehan syndrome is a global or partial pituitary defect occurring after an obstetrical haemorrhage.The aim of this study is to describe metabolic complications in 46 consecutive patients with Sheehan syndrome and to determine correlations between these complications and the clinical, hormonal and therapeutic aspects of this syndrome.All patients have had a physical examination: weight measurement, body mass index (BMI) determinati...

ea0022p629 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Flexion contractures syndrome as the initial manifestation of hypopiptuitarism

Insaf Hadj Ali , Karima Khiari , Nadia Mchirgui , Youssef Lakhoua , Nejib Ben Abdallah

We present a 58 years old woman admitted in our department for bradycardia, diarrhea, epigastralgia, anorexia and weight loss. Physical examination showed low blood pressure and inability to walk or stand due to severe flexion contractures of the lower extremities without neurological abnormalities. The biological findings showed severe hyponatremia, hyerkaliemia tendency, low levels of plasma cortisol and ACTH suggesting pituitary adrenal axis deficiency. Hormonal investigati...

ea0056ep48 | Diabetes, Obesity and Metabolism | ECE2018

Diabetes during paraneoplastic cushing: about two cases

Khiari Marwa , Nacef Ibtissem Ben , Mechrigui Nadia , Lakhoua Youssef , Khiari Karima , Abdallah Nejib Ben

Diabetes in paraneoplastic Cushing is often severe with a risk of acute metabolic complications.Observation n° 1: A 36-year-old patient, with no medical history, was hospitalized for inaugural diabetic ketoacidosis with no intercurrent infection. The physical examination found facio-truncal obesity, amyotrophy of extremities, melanoderma, arterial hypertension and severe psychiatric disorders. The blood tests showed an hypokalemia at 1.9 mmol/l. Hig...

ea0056ep49 | Diabetes, Obesity and Metabolism | ECE2018

Diabetes profile during cyclic Cushing syndrome: about one case

Khiari Marwa , Rojbi Imen , Mechergui Nadia , Lakhoua Youssef , Khiari Karima , Abdallah Nejib Ben

Endogenous CushingÂ’s syndrome comes generally with permanent hypercorticism often complicated by diabetes which can be difficult to control. However, the cortisolÂ’s excessive production may be cyclic or intermittent, and, therefore, complications may have a specific course which leads to diagnostic and therapeutic delay.Observation: We report the case of a 28-year-old woman with no previous medical history who was hospitalized for a Cushing&#14...

ea0073aep41 | Adrenal and Cardiovascular Endocrinology | ECE2021

A case of adrenergic myocarditis in pheochromocytoma mimicking COVID-19 pneumonia

Adel Meriem , Rojbi Imen , Majdoub Marwa , Mchirgui Nadia , Lakhoua Youssef , Nacef Ibtissem Ben , Khiari Karima

IntroductionPheochromocytomas are rare catecholamine-producing neuroendocrine tumors derived from the sympathetic or parasympathetic nervous system. The clinical presentation of pheocromocytoma has varying forms, which makes diagnosing it challenging. Here, we report a case of Adrenergic cardiomyopathy mimicking COVID-19.Case reportA 40-year-old woman with a history of pulmonary edema during cesarean delivery...

ea0073aep393 | Endocrine-Related Cancer | ECE2021

Severe hypoglycemia: First manifestation of an advanced hepatocellular carcinoma

Elhaj Wiem Ben , Rojbi Imen , Adel Meriem , Mchirgui Nadia , Lakhoua Youssef , Nacef Ibtissem Ben , Khiari Karima

BackgroundHypoglycemia is a well-established as a serious paraneoplastic complication of hepatocellular carcinoma (HCC). However, hypoglycemia presenting the first presentation of HCC is not frequent. In this regard, we present the case of a patient who had hypoglycemia as first manifestation of HCC.ObservationA 55yearold man presented to the Emergency Department with loss of consciousness preceded by dizzine...