Endocrine Abstracts

Hyponatremia is one of the commonest electrolyte abnormality. Various neurological conditions including Guillain Barre syndrome could precipitate it. Very few citations in literature report SIADH in CIDP.A 68-year-old gentleman was admitted with worsening confusion and unsteady gait following a flu like illness few weeks ago, with increasing drowsiness for 3 days. His past medical history included hypertension and benign prostatic hypertrophy, being trea...

Background: Vitamin-D deficiency and type 2 diabetes (T2D) are common in South Asians (SA). The diagnosis of a vitamin-D deficiency in the setting of a chronic disease depends on a high index of suspicion and adequate investigation. This involves bone profile, occasionally in conjunction with serum 25-hydroxyvitamin-D. The ability of routine investigations to identify vitamin-D deficient patients have not been widely studied.Aims: To assess the ability o...

Cushing’s syndrome is a rare disorder of hypercortisolism with an incidence of three cases per million each year. The 1 mg overnight dexamethasone suppression test (ODST) is a commonly used screening test. Other screening tests include 24 h urinary free cortisol and diurnal variability of serum cortisol.We carried out an audit of ODST with the intention of examining patient outcome.Data were collected retrospectively over a tw...

Generalised resistance to glucocorticoid is a rare familial or sporadic disease with partial target tissue insensitivity to glucocorticoids. Compensatory activation of the hypothalamo–pituitary–adrenal axis occurs with raised andrenocorticotrophic (ACTH) hormone levels and increased synthesis of adrenal steroids. The phenotype varies from asymptomatic to excess glucocorticoid, mineralocorticoid and androgenic effects.A 20-year-old female was fo...

A 45-year-old male to female transsexual presented with poor female fat distribution. She had been treated with oestrogen for 13 years, initially as ethinyl oestradiol to a maximum dose of 150 ug/day, presently taking 100 mcg with GNRH analogue. On this regimen she had B cup breast development but underwent breast augmentation surgery and still suffered from low self-esteem. She was dissatisfied with her body image because she perceived a male body fat distribution. Her initia...

Aim: Thyroidectomy is a common surgical procedure done in adults. However, thyroid surgery in children is infrequently undertaken. But due to genetic screening of families with multiple endocrine neoplasia (MEN) syndromes, more paediatric thyroidectomies are being performed. It is suggested that general and endocrine specific complications in children after thyroid surgery are higher than in adults. In this study we explored the indications for thyroidectomy and the post opera...

Radio-iodine is a safe and effective treatment of thyrotoxicosis, but carries a risk of the late development of hypothyroidism several years after therapy. Patients treated with radio-iodine require long-term follow-up to ensure that late hypothyroidism is detected and treated. Current changes in health care commissioning propose an increasing reliance on primary care for the long term follow-up of patients with thyroid disease. We report a study of the 8 year follow-up of 100...

Introduction: Septo optic dysplasia is a triad of conditions, which include MPHD, IGHD and ONH. We have analysed data in our regional cohort primarily focusing on MRI brain scans.Patients and methods: MRI scans of the brain including T1/T2 weighted high resolution images in children with a diagnosis of septo optic dysplasia (SOD (N=38)), multiple pituitary hormone deficiency (MPHD (N=19)) and isolated GH deficiency (IGHD (n=14)) (tot...

Aim: Thyroid surgery in children is infrequently undertaken, but due to genetic screening of families with multiple endocrine neoplasia (MEN) syndromes, more paediatric thyroidectomies are being performed. In this study we explored the indications for thyroidectomy and the post operative course and consequences of surgery carried out in our unit.Methods: Retrospective review of medical case notes of children who had either total or partial thyroidectomie...

Context: Exogenous oestrogen administration causes prolactinoma formation in rats and there are anecdotal reports of oestrogen treatment and prolactinoma formation in gender reassignment males to females. It remains unclear whether chronic exposure to high dose oestrogen in women is linked with prolactinoma development.Aim: The aim of this study was to determine the effect of high dose subcutaneous estrogen on prolactin and gonadotrophin levels of 101 wo...