Searchable abstracts of presentations at key conferences in endocrinology

ea0013p80 | Clinical practice/governance and case reports | SFEBES2007

Hyperchloraemic metabolic acidosis with hypokalaemia and osteomalacia

Gardner Daphne S-L , Flanagan Daniel E

Background: A 52-y-old lady (Mrs M) presented with a 10-day history of progressive generalised weakness, dysarthria and un-coordination. 26 y ago, she had cervical carcinoma, requiring a hysterectomy, oophorectomy and radiotherapy. This led to a vesicovaginal fistula, requiring a cystectomy and ureterosigmoidostomy. She is known to have osteoporosis. Medications: calfovit D3 one/d (started 5 days prior to admission), risedronate, lansoprazole. She had HRT until 50 y. Examinati...

ea0013p158 | Diabetes, metabolism and cardiovascular | SFEBES2007

Modification of insulin receptor exon 11 alternative splicing by antisense oligonucleotides

Srirangalingam Umasuthan , Chew Shern L , Khoo Bernard

Introduction: There are two isoforms of the insulin receptor (IR), generated by the alternative splicing of exon 11 to give IR-A (exon 11-) and IR-B (exon 11+) isoforms. The differing distribution and function of the isoforms has been postulated to play a role in the pathogenesis of diabetes mellitus, myotonic dystrophy and thyroid carcinoma. Previous work investigating IR alternative splicing has identified hormonal factors, splicing elements and factors which modulate the re...

ea0011s35 | Clinical lessons from novel aspects of G protein-coupled receptors signalling | ECE2006

Alpha- and beta-adrenoceptor dysfunction

Hein L , Beetz NB , Knaus A , Muthig V

The family of adrenergic receptors contains nine different subtypes of G protein-coupled receptors which mediate the biological effects of adrenaline and noradrenaline. With few exceptions, the full therapeutic potential of subtype-selective therapy has not yet been explored for the group of adrenergic receptors. In the absence of sufficiently subtype-selective ligands which can distinguish between individual receptor subtypes of the adrenergic family, gene-targeted mouse mode...

ea0011p80 | Clinical case reports | ECE2006

Long-term outcome of untreated Cushing’s syndrome due to pituitary microadenoma

Nduwayo L , Othmani J , Rousseaux P

Background: The diagnosis of Cushing’s syndrome is based on clinical suspicion and biochemical confirmation. Most cases are caused by an ACTH secreting pituitary microadenoma. In its severe form and when untreated, Cushing’s syndrome is associated with high mortality. We report a case of untreated Cushing’s syndrome due to pituitary microadenoma 8 years after the earlier manifestations.Observation: A 21-years-old woman was referred for pro...

ea0011p110 | Clinical case reports | ECE2006

Post-partum thyroiditis (PPT): colour-doppler ultrasonography evaluation

De Remigis P , De Remigis A , Vianale L

Colour-Doppler Ultrasonography (CDU) is applied to the study of many thyroid diseases. In the last one semiquantitative (colour-signal) and quantitative (peak flow velocity at inferior thyroid artery) evaluations are considered. Graves’ disease (GD), amiodarone-induced thyrotoxicosis were better characterized, even Hashimoto thyroiditis and De Quervain thyroiditis were studied. We described a case of Silent Thyroiditis (ST), showing the possibility to distinguish it from ...

ea0011p288 | Diabetes, metabolism and cardiovascular | ECE2006

Mortality risks of diabetic patients who reach end stage renal disease (ESRD) in the united states: age and gender differences

Stack AG , O’Shea L

Prior studies have demonstrated that diabetes as a cause of or contributing factor to end stage renal disease (ESRD) has a detrimental impact on survival. What is unclear is whether this effect varies by age and gender.Methods: The objective of this study was to evaluate mortality differences by age and gender among diabetic and non-diabetic ESRD patients in a national cohort. Data on all new ESRD patients (n=451,296) who were initiated on dialysi...

ea0011p422 | Diabetes, metabolism and cardiovascular | ECE2006

Correlations between leptin, insulin resistance and lipid profile in postmenopausal women

Poiana C , Stoian L , Stefanescu AM

Leptin is a circulating hormone produced primarily by the adipose tissue, which controls food intake and energy homeostasis. Important peripheral actions of leptin involve inhibition of insulin biosynthesis and secretion in pancreatic ß-cells. In turn, insulin stimulates leptin secretion from adipose tissue, establishing a hormonal regulatory feedback loop: ‘adipo-insular axis’. The aim of our study was to determine the interrelations between leptin, insulin/ins...

ea0011p617 | Neuroendocrinology and behaviour | ECE2006

The levels of ghrelin and leptin and body fat mass in patients treated for thyroid dysfunction

Brunova J , Karasova L , Kasalicky P

Introduction: Patients successfully treated for hyperthyroidism show often the excessive weight gain and patients with hypothyroidism seldom regain their premorbid weight despite satisfactory control of their thyroid function.Aim of study: We compared the levels of hormones of ghrelin and leptin in patients with hyper and hypothyroidism, treated and untreated. We aimed to find if they play a role in a new energy balance in these patients.<p class="ab...

ea0011p738 | Steroids | ECE2006

Long-term glucocorticoid repression of pro-opiomelanocortin (POMC) expression

Eltobgi A , Abbott L , Newell-Price J

Background: A functioning Hypothalamo-pituitary-adrenal (HPA) axis is essential for life. Prolonged high circulating levels of glucocorticoids inhibit pituitary Pro-opiomelanocortin (POMC) gene expression. Repression continues even in the absence of continued glucocorticoid exposure. To date there are no molecular explanations for this observation.Hypothesis: Long-term exposure to glucocorticoids causes de-novo DNA methylation of the pituit...

ea0057037 | Euglycemic ketoacidosis in diabetes type 1 | BES2018

Euglycemic ketoacidosis in diabetes type 1

Van den Mooter L , Mathieu C

Background: SGLT2i have shown promising results as an adjunct therapy in T1DM, resulting in better glucose control, weight loss and lower blood pressure. No increase in hypoglycemia risk, in particular severe hypoglycemia, was observed, but, an mild increased risk of (euglycemic) diabetic DKA was reported (Van den Mooter L. et al. Exp Opinion Pharm 2018).Case report: A 49-year-old Caucasian female nurse with underlying type 1 diabetes was admitt...