Searchable abstracts of presentations at key conferences in endocrinology

ea0005p22 | Clinical Case Reports | BES2003

A little hard to swallow. A rare cause of dysphagia in scleroderma

Wright K , Albon L , Gittoes N

A 41 year old woman presented with a 4 month history of oropharyngeal spasms precipitated by eating, yawning or talking. Such manouvres caused her to fear for her life due to profound choking and 'going blue';as a result she had stopped eating. On direct questioning she complained of circumoral tingling, paraesthesia and carpopedal spasm. She described profuse diarrhoea over the preceding year and had lost 15 kilograms. She was taking no drugs to interfere ith calcium homeosta...

ea0005p26 | Clinical Case Reports | BES2003

"My feet are killing me!" An unusual presentation of Cushing's syndrome

Albon L , Rippin J , Franklyn J

Adverse effects of steroid excess on bone metabolism are well established but presentation of Cushing's syndrome with metabolic bone disease is reported to be uncommon. We describe a case of Cushing's syndrome presenting with pathological fractures probably present for 8 years before diagnosis.A 33 year old nurse first sustained spontaneous stress fractures of her metatarsals in 1994, with repeated fractures occurring up to 2002. In 2001 she developed hypertension, acute l...

ea0005p34 | Clinical Case Reports | BES2003

Developing an endocrine nurse specialist post can improve service to patients with endocrine disease

Munday L , Wotherspoon F , Meeking D

BACKGROUND: Dynamic function tests are needed to diagnose a range of endocrine disorders but often require in-patient investigation. A recent audit of our endocrine service revealed deficiencies that included frequent delay to investigations and cancellation of planned appointments. We developed an Endocrine Nurse Specialist (ENS) post whose role included carrying out endocrine testing in an out-patient setting to assess whether this might improve quality of care for our patie...

ea0005p55 | Clinical Case Reports | BES2003

Growth hormone deficiency and pregnancy

Brackenridge A , Breen L , Russell-Jones D

It is recognised that growth hormone deficiency causes disturbances in reproductive function. Indeed growth hormone has been used for ovulation induction in the treatment of subfertility in women with hypopituitarism. During normal pregnancy growth hormone is produced by the placenta (placental growth hormone). From 15 to 20 weeks gestation placental growth hormone gradually replaces pituitary growth hormone in the maternal circulation and is the main determinant of maternal I...

ea0005p158 | Endocrine Tumours and Neoplasia | BES2003

Retrospective audit of care of patients undergoing pituitary surgery in Plymouth

Wotherspoon F , Dyer R , Pobereskin L

BACKGROUND: An audit of facilities and medical and surgical care based on the 1997 Royal College of Physicians and Society for Endocrinology guidelines for the management of pituitary tumours was carried out in the South West in 2001. We present the results for patients referred to one specialist pituitary surgeon in Plymouth.METHODS: 1. A questionnaire was sent to each endocrinology department covering staff resources, facilities for investigations and the process of care...

ea0005p245 | Steroids | BES2003

Audit of adrenal vein sampling for primary aldosteronism

Sibal L , Raza A , Leen B , Kelly W

INTRODUCTION: Hypertension with hypokalaemia suggests primaryaldosteronism, which is confirmed by high plasma aldosterone with low renin concentrations. CT and MRI scans frequently fail to detect small primary aldosteronomas, and may incorrectly identify ' incidentalomas', so adrenal vein sampling is needed.AIM: To review the clincal and biochemical results on 12 patients who had catheter sampling of adrenal and ivc aldosterone(A) and Cortisol (C)with calculation of Aldosteron...

ea0004oc25 | Neuroendocrinology and diabetes | SFE2002


Larder R , Chang L , Brown P

In women, gonadotropin releasing hormone (GnRH) is secreted from the hypothalamus and conveyed via the portal vasculature to the anterior pituitary gland every 60-90 minutes. This binds GnRH receptor and triggers pulsatile release of gonadotrophin hormones, Follicle stimulating and Luteinising hormone (FSH and LH), which stimulate and regulate folliculogenesis. The interdependence of these events accounts for the high number of cycling disorders in women, and the origin of the...

ea0004p44 | Diabetes, metabolism and cardiovascular | SFE2002

A Possible Role for Protein Kinase C Epsilon in Growth Hormone Signalling

Semple J , Pooley L , Vernon R

Growth hormone (GH) acts chronically to decrease adiposity, at least in part by the inhibition of lipogenesis. One or more of the twelve isoforms of Protein kinase C (PKC) may be involved in this chronic effect of GH on lipogenesis in adipocytes.Two approaches were adopted to examine the role of PKC isoforms in GH signalling. The first method involved maintaining explants of Finn/Dorset sheep adipose tissue with insulin, GH or a combination of both, for ...

ea0004p88 | Steroids | SFE2002

Measurement of urinary 18-hydroxytetrahydro-11-dehydrocorticosterone (18-OHTHA) excretion rate by gas chromatography-mass spectrometry using the heterologous standard, beta-cortol

Shakerdi L , Connell J , Fraser R , Wallace A

Introduction. As for many minor metabolites of steroids, no authentic standard is commercially available for 18-OH-THA. This compound is the principal urinary metabolite of 18-hydroxycorticosterone, a putative intermediate in the synthesis of aldosterone and of diagnostic value in screening for hypermineralocorticoidism. Since de novo synthesis is time-consuming and expensive, we tested the possibility of using beta-cortol, which produces an ion at m/z 457 in common wit...

ea0004p94 | Thyroid | SFE2002

Apoptotic gene expression in Autoimmune Thyroid Disease

Waheed S , Hammond L , Biro A , Mirakian R

Apoptosis or programmed cell death, is a principal mechanism controlling the physiological development of most living organs by removing unwanted cells without inducing an inflammatory response. It is known that in autoimmune thyroid conditions such as Graves' disease, thyroid cells die by apoptosis. Dysregulation of pro- and anti-apoptotic gene expression may be critical to the induction of the destructive process via the activation of a sequence of caspases (proteases).<...