Searchable abstracts of presentations at key conferences in endocrinology

ea0014oc4.4 | Neuroendocriology basis | ECE2007

Is there a role for dopamine D2 receptor gene polymorphisms in determining cabergoline sensitivity in prolactin-secreting pituitary adenomas?

Filopanti Marcello , Barbieri Anna Maria , Angioni Rita , Lania Andrea , Mantovani Giovanna , Spada Anna , Beck-Peccoz Paolo

Dopamine agonist cabergoline (CB) is the first-choice treatment in prolactin-secreting adenomas (PRL-omas). It is effective in reducing PRL secretion and tumour size in about 90% of patients by binding dopamine D2 receptor (DRD2). Although no mutations in DRD2 were found, it has been reported that several polymorphisms of this locus associate with alcoholism and schizophrenia, diseases in which dopaminergic system plays an important role. To assess the possible asso...

ea0014p532 | (1) | ECE2007

Growth hormone deficiency and recombinant hGH (rhGH) replacement in children with idiopathic isolated GH deficiency: effects on the hypothalamus-pituitary-adrenal axis

Bergamaschi Silvia , Giavoli Claudia , Ferrante Emanuele , Rusconi Roberto , Lania Andrea G , Spada Anna , Beck-Peccoz Paolo

Cortisol and cortisone are interconverted by type 1 and type 2 11ßhydroxysteroid dehydrogenase (11ßHSD) isoenzymes. The type 1 isoenzyme is a widely expressed reductase that converts cortisone to cortisol regulating glucocorticoid tissue exposure. Its activity is inhibited by GH and IGF-I, being increased in GH deficiency (GHD) and decreased in acromegaly. In our experience rhGH therapy unmasked a central hypoadrenal state in adults with organic GHD, likely by normal...

ea0056gp18 | Adrenal Case reports | ECE2018

Bilateral testicular masses and adrenal insufficiency in a young adult: is congenital adrenal hyperplasia the only possible diagnosis?

Tresoldi Alberto Stefano , Betella Nazarena , Pizzocaro Alessandro , Lania Andrea Gerardo Antonio

Testicular adrenal rest tumours (TARTs) are benign tumours deemed to originate from ectopic adrenal cells that descend with the testes during fetal development. These cells grow under chronic ACTH stimulation, typically in patients with congenital adrenal hyperplasia (CAH). TARTs have also been rarely described in other conditions characterised by chronically elevated ACTH, such as autoimmune primary adrenal insufficiency (PAI). These are benign lesions, but could be misdiagno...

ea0081p709 | Reproductive and Developmental Endocrinology | ECE2022

Serum testosterone mirrors inflammation parameteres in females admitted with covid-19 disease

Francesca Birtolo Maria , Vena Walter , Pizzocaro Alessandro , Jaafar Simona , Ciafardini Antea , Brunetti Alessandro , Pigni Stella , Mazziotti Gherardo , Lania Andrea

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is showing a rapid and continuous evolution in terms of new waves, the spread of variants and the evidence of reinfections. The growing heterogeneity of clinical presentation requires the identification of underlying pathogenic mechanisms to allow a better risk stratification. Previous studies analysed the role of sex hormones in disease severity demonstrating in male patients the association of...

ea0081p734 | Thyroid | ECE2022

Short and long-term efficacy of image-guided laser and radiofrequency ablation therapies: a prospective monocentric and single-operator study

Francesca Birtolo Maria , Antonini Simone , Ierace Tiziana , Cristofolini Giacomo , Maida Giulia , Mazziotti Gherardo , Lania Andrea , Solbiati Luigi

Background: In the last decades mini-invasive techniques have been proposed to reduce costs and complications of emithyroidectomy and thyroidectomy, both for benign nodular goiter and thyroid microcarcinoma, and image-guided laser and radiofrequency ablation are the most used.Purpose: To investigate short and long-term efficacy of image-guided laser and radiofrequency ablation as therapy options for benign nodular goiter.Methods: F...

ea0081ep594 | Endocrine-Related Cancer | ECE2022

New CDKN1b mutation in multiple endocrine neoplasia type 4 and brief literature review on clinical management.

Brunetti Alessandro , Lavezzi Elisabetta , Bertuzzi Alexia , Nappo Gennaro , Laffi Alice , Pedicini Vittorio , Vitali Eleonora , Trivellin Giampaolo , Mazziotti Gherardo , Lania Andrea

Background: The fourth type of Multiple Endocrine Neoplasia (MEN) is a rare variant of MEN presenting a MEN1-like phenotype and originating from a germline mutation in CDKN1B. However, due to the small number of cases documented in literature, the peculiar clinical features of MEN4 are still largely unknown, and clear indications about the clinical management of these patients are currently lacking. In order to enlarge our knowledge on MEN4 and to better typify the clinical fe...

ea0063gp164 | Cushing's | ECE2019

Assessment of bone marrow fat by single-voxel vertebral magnetic resonance spectroscopy in cushing’s syndrome with or without vertebral fractures

Ferrau Francesco , Giovinazzo Salvatore , Tessitore Agostino , Messina Erika , Vinci Sergio , Mazziotti Gherardo , Lania Andrea , Longo Marcello , Granata Francesca , Cannavo Salvatore

Chronic hypercortisolism is associated with dramatic increase in fragility fractures. The evaluation of skeletal fragility in Cushing’s syndrome (CS) is a clinical challenge, since fractures may occur even in presence of normal bone mineral density (BMD). Recently, measurement of bone marrow fat (BMF) by vertebral magnetic resonance spectroscopy (MRS) was proposed as alternative tool for evaluating skeletal fragility in primary and secondary osteoporosis. Noteworthy, rece...

ea0049ep924 | Pituitary - Basic | ECE2017

SSTR2 inhibits GH-secreting pituitary tumoral cells migration and invasion by increasing cofilin phosphorylation

Peverelli Erika , Giardino Elena , Treppiedi Donatella , Locatelli Marco , Lania Andrea G , Arosio Maura , Spada Anna , Mantovani Giovanna

Although generally benign, pituitary tumors frequently present local invasiveness that strongly reduces neurosurgery success. We recently demonstrated a role for the actin binding protein cofilin in promoting non functioning pituitary tumors invasiveness and an inhibitory effect of dopamine receptor type 2. Somatostatin (SS) receptor type 2 (SSTR2) is the main target of pharmacological therapy of GH-secreting pituitary tumors, reducing both GH secretion and cell proliferation,...

ea0041gp111 | Endocrine Tumours | ECE2016

Implication of Filamin A in pulmonary neuroendocrine tumors aggressiveness and progression

Vitali Eleonora , Ferrero Stefano , Peverelli Erika , Veronesi Giulia , Alloisio Marco , Santambrogio Luigi , Spada Anna , Mantovani Giovanna , Lania Andrea

Pulmonary neuroendocrine tumors (PNTs) comprise a spectrum of neoplasms, ranging from low grade carcinoids to the highly malignant small cell lung cancers. Several studies identified cytoskeleton protein Filamin A (FLNA) as determinant in cancer progression and metastasis. To date, the role of FLNA in PNTs aggressiveness and progression is still unknown.To address this question, we decided: i) to evaluate FLNA expression in PNTs ranging from typical carc...

ea0037gp.28.05 | Endocrine tumours and neoplasia – NETS | ECE2015

Filamin-A is involved in stabilisation, signal transduction, and angiogenesis regulation mediated by somatostatin receptor 2 in pancreatic neuroendocrine tumors

Vitali Eleonora , Cambiaghi Valeria , Loiarro Federica , Zerbi Alessandro , Colombo Piergiuseppe , Spada Anna , Mantovani Giovanna , Peverelli Erika , Carnaghi Carlo , Lania Andrea

Somatostatin receptor type 2 (SST2) is the main pharmacological target of long-acting somatostatin analogues (SSA) widely used in patients with pancreatic neuroendocrine tumours (P-NETs). A subset of patients is resistant to SSA, although the molecular mechanisms responsible for resistance are poorly understood. Several studies identified cytoskeleton protein interactions as determinant in receptor anchoring, expression and signalling. Since SST2 was recently demonstrated to a...