Endocrine Abstracts

Pro-opiomelanocortin (POMC) is endoproteolysed to ACTH and alpha MSH which bind to the melanocortin-1 receptor, (MC-1R), and act as principal mediators of human skin pigmentation. In addition there is increasing evidence that alpha MSH has important anti-inflammatory actions in the skin. The aim of this study was to determine the efficiency of processing and the involvement of the different peptides in melanogenesis. To address this question we utilized specific two-site immun...

Objectives: To determine if a single intra- or peri-articular injection of corticosteroid for post-traumatic or microtraumatic skeleton injuries in healthy young subjects would induce a suppression of hypothalamo-pituitary-adrenal axis activity and reactivity.Methods: 10 young healthy male sportsmen (28.8±2.5 years) received a single intra- or peri-articular injection of either cortivazol or betamethasone for post-traumatic or microtraumatic skeleto...

Glucocorticoids (Gcs) act via the glucocorticoid receptor (GR) to inhibit proliferation of many epithelial cell types, and induce apoptosis in others, notably lymphoblastic leukemia. Resistance to Gcs occurs in human small cell lung cancer (SCLC), manifest clinically as dysregulated secretion of ACTH-related peptides. Currently nothing is known of the biological consequences such resistance causes. We have previously shown that a panel of human SCLC cell lines secrete ACTH rel...

BackgroundThe gut hormone peptide YY (PYY) is released postprandially acting as a satiety signal. Obese adults have reduced concentrations of PYY in the fasting and postprandial state. Animal data suggest that lower PYY levels are likely to be a consequence rather than a cause of obesity. We aimed to investigate PYY in the fasting state and after a 420 kcal meal in post pubertal children.MethodNine normal wei...

ObjectiveBariatric surgery has an important role in the management of morbidly obese patients. Roux-en-Y gastric bypass (RYGB) is an established bariatric procedure. In this study, we aimed to investigate prospective changes in the entero-hypothalamic endocrine axis following RYGB, examining the meal-stimulated responses of peptide-YY (PYY), glucagon-like peptide 1 (GLP-1) and ghrelin.MethodsSix female patien...

Background: Obese subjects are usually in a positive energy balance despite their best efforts to lose weight. This study aimed to determine if hunger, nausea and satiety levels differ in lean and obese subjects after consuming varying calorific meals.Method: Following an overnight fast, test meals of 250, 500, 1000, 2000 and 3000 kcal were consumed by 19 lean and 19 obese subjects. Hunger, nausea and satiety levels were measured using visual analogue sc...

Glucocorticoid sensitivity is dependent on the intracellular concentration of the glucocorticoid receptor (GR). GR expression is regulated in a complex, cell-type specific manner, but in most cell types the GR is subject to negative autoregulation by glucocorticoid exposure. Many human diseases are associated with reduced tissue sensitivity to glucocorticoids, including inflammatory arthritis, asthma, and chronic obstructive pulmonary disease. Therefore there is interest in ap...

Background: Lamin A/C mutations show heterogeneous phenotypes expanding from cardiopathies to lipodystrophies. R482-LMNA gene mutation is the hot-spot for familial partial lipodystrophic syndromes (FPLD2) and is characterized by an increase of intra-abdominal (visceral) fat. In contrast, the visceral fat phenotype of non-R482-LMNA mutated patients has not been well studied.Objectives: To compare the fat amount and visceral repartition o...

Introduction: LMTK3 is an oncogenic Receptor Tyrosine Kinase (RTK) implicated in resistance to endocrine therapy in breast cancer. Initially, LMTK3 was described as a regulator of Estrogen Receptor alpha (ERα) since it was found able to protect it from ubiquitin-mediated proteasomal degradation. In a cohort of breast cancer (BC) patients (n>600), LMTK3 protein levels and intronic polymorphisms were significantly associated with disease-free and overall surviv...

Introduction: Oxidative stress (OX) plays a role in the pathogenesis of moderate to severe Graves’ ophthalmopathy (AMS-GO).Aim: We evaluated the impact of clinical conditions related to OX on the outcome of parenteral glucocorticoids (PGLUC) therapy in AMS-GO.Methods: We retrospectively evaluated patients with AMS-GO treated with PGLUC from January 2013 to May 2022. GO clinical evaluation was performed at baseline, at 6 (W6), ...