Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep376 | Diabetes (pathiophysiology & epitemiology) | ECE2015

Gonadal hormone regulates the expression MATE1 and OCT2 in type 2 diabetes mice

Ai Ligen , Zhang Dandan , Hou Wolin , Lu Junxi , Tang Junling , Lu Huijuan , Zheng Taishan , Liu Fang

Background and aims: Multi-drug and toxin extrusion 1 (MATE1) and organic cation transporters 2 (OCT2) are important proteins of metformin transport and excretion in liver and kidney. Our previous study showed that there were gender difference of metformin’s hypoglycaemic effect and it was independently linked with the oestrogen and testosterone levels in type 2 diabetes patients. This study was designed to observe the impact of oestrogen and androgen on the renal express...

ea0070ep451 | Thyroid | ECE2020

When levothyroxine is not enough- combination therapy with liothyronine

Veríssimo David , Reis de Almeida Luís , Monteiro Manuel , Dias Luís

Introduction: The treatment of central hypothyroidism with a combination of levothyroxine (T4) and liothyronine (T3) is not recommended for most patients since it does not show an advantage over T4L monotherapy. However, in certain patients who remain symptomatic under replacement therapy with T4L and thyroid stimulating hormone (TSH) within the reference values, combined treatment with T4 and T3 can be tested.Clinical case: Male, 39 years old, medical h...

ea0090ep698 | Pituitary and Neuroendocrinology | ECE2023

Are neurosteroids related to anxiety and quality of life in cases with acromegaly?

Burhan Sebnem , Hacıoğlu Yalcın , Polat Yeliz , Furkan Arslan Hilmi , Balcı Ekmekci Ozlem , Niyazoğlu Mutlu , Hatipoğlu Esra Şuheda

Background: Anxiety level is higher in the samples consisting of people diagnosed with pituitary adenoma, including patients with acromegaly, compared to the normal population. A higher level of anxiety indicates a lower Quality of Life (QoL) in acromegaly. This study aimed to evaluate and discuss the possible relationship between anxiety and NS in people with acromegaly.Method: This cross-sectional comparative study included an acromegaly group (AG, <em...

ea0050apw1.1 | Tissue Engineering for Regenerative Medicine in Endocrinology | SFEBES2017

Reprogramming gastric tissues for insulin production

Ariyachet Chaiyaboot , Lu Jiaqi , Kim Hyunkee , Zhou Qiao

Generating functional insulin-secreting cells is a major goal of developing cell therapies for diabetes. Studies have shown that insulin+ cells can be derived from non-beta cells by cellular reprogramming. We carried out a genetic screen in mouse to identify adult cell types amenable for direct conversion to insulin+ cells by a cocktail of reprogramming factors (Ngn3, Pdx1, and Mafa, termed NPM factors). Surprisingly, the antral stomach epithelial cells w...

ea0050apw1.1 | Tissue Engineering for Regenerative Medicine in Endocrinology | SFEBES2017

Reprogramming gastric tissues for insulin production

Ariyachet Chaiyaboot , Lu Jiaqi , Kim Hyunkee , Zhou Qiao

Generating functional insulin-secreting cells is a major goal of developing cell therapies for diabetes. Studies have shown that insulin+ cells can be derived from non-beta cells by cellular reprogramming. We carried out a genetic screen in mouse to identify adult cell types amenable for direct conversion to insulin+ cells by a cocktail of reprogramming factors (Ngn3, Pdx1, and Mafa, termed NPM factors). Surprisingly, the antral stomach epithelial cells w...

ea0041gp41 | Bone &amp; Calcium Homeostasis (1) | ECE2016

A serum 25 hydroxy-vitamin D concentration in search of a bone disease

Shah Sonali , Chiang Cherie , Sikaris Ken , Lu Zhong , Seeman Ego

Introduction: Vitamin D insufficiency and deficiency are defined as a serum 25-hydroxy-vitamin D (25(OH)D) below 50 and 30 nmol/l respectively. We aimed to determine whether there is a serum 25(OH)D that signals a low serum calcium and phosphate, secondary hyperparathyroidism, high bone remodelling, low area bone mineral density (aBMD), and so, an increased risk for microstructural deterioration and bone fragility.Method: Concentrations of 25(OH)D, calci...

ea0070ep381 | Reproductive and Developmental Endocrinology | ECE2020

46, XX male syndrome- testicular disorder of sexual differentiation

Köseoğlu Derya , Helvaci Nafiye

Introduction: 46, XX male syndrome–testicular disorder of sexual differentiation (DSD) is a rare condition, that was first described by la Chapelle et al. in 1964. The phenotypes of 46, XX testicular DSD include males with normal phenotype, males with genital ambiguities or males with true hermaphrodites. The diagnosis may be more difficult in adults with normal gender development than in children. Here, we present hormonal and cytogenetic conditions of an adult male who...

ea0032p388 | Diabetes | ECE2013

Identification of plasma biomarkers in human diabetic retinopathy

Lee Ying-Ray , Lu Chieh-Hsiang , Chan Hong-Lin

Retinopathy has been observed in around 25% of patients with type one and type two diabetes for 3–5 years. Diabetic retinopathy can cause poor vision and even blindness since high glucose has been evidenced to weaken retinal capillary leading to leakage of blood into the surrounding space. Therefore, the prevention, diagnosis and therapy of diabetes retinopathy are very important in diabetes patients. Here, we adopted a proteomics-based approach using 2D-DIGE and MALDI-TO...

ea0031p167 | Neoplasia, cancer and late effects | SFEBES2013

Crizotinib induced hypogonadism: a novel complication of lung cancer treatment

Lu Shir Kong , Htay Thein , Popat Sanjay , Morganstein Daniel

Tyrosine kinase inhibitors and other targeted treatments are revolutionizing the treatment of cancer. However multiple endocrine side effects of these treatments are emerging.Crizotinib, a multi-targeted small molecule tyrosine kinase inhibitor of ALK and c-met, has been approved by the FDA for the treatment of non small cell lung cancer (NSCLC) patients with a novel oncogenic gene fusion, EML4-ALK and its variants. Crizotinib is generally well tolerated...

ea0028p218 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2012

Unique roles of CRH-Rs controlling adipocyte biology and transdifferentiation

Lu Buyu , Markovic D. , Pessin Jeff , Lehnert Hendric , Grammatopoulos Dimitris

In addition to well established role in coordinating mammalian adaptive responses to stressful stimuli, the family of “stress” peptides that includes corticotropin releasing hormone (CRH) and urocortins (Ucns) are emerging as important regulators of the homeostatic mechanisms regulating energy balance and metabolism. CRH acting through specific G-protein coupled receptors, CRH-R1 and R2 can target multiple peripheral tissues such as skeletal muscle and adipose tissue...