Endocrine Abstracts

Background: Radioiodine (RAI) therapy has been used for a long time in benign and malign diseases of the thyroid gland. During the application of radioiodine treatment, parathyroid glands may also be exposed to radiation due to its close proximity to the thyroid gland. There is interest in the effects of RAI treatment on parathyroid functions in clinical studies. The aim of this study is to evaluate whether the dose of RAI treatment for benign or malignant thyroid diseases has...

Aim: Serum sclerostin levels as an indicator of bone resorption in children with congenital adrenal hyperplasia (CAH) have not been evaluated to date. The aim of this study was to determine the role of osteoprotegerin (OPG) and sclerostin in bone metabolism in children with CAH.Methods: Thirty-one patients (19 girls, 12 boys) with CAH (aged 11.6±3.7 years) and 31 healthy children (age- and sex-matched) as controls were included in the study. The patie...

Neuroendocrine tumors (NETs) of the breast are very rare. They represent less than 1% of breast carcinomas. It is important to differentiate metastatic neuroendocrine neoplasia from primary neuroendocrine neoplasia of the breast. Histopathological misinterpretation of a breast NET is common. In a study of 18 NET cases that metastasized to the breast, it was found that 62% of these tumors originated from the gastrointestinal tract and 28% from the lung. Forty-four percent of th...

Introduction: Feochromositoma is a rare neuroendocrine tumor derived from chrommaffin cells of adrenal medulla. The most characteristic clinical symptoms are headache, perspiration, palpitation, and paroxysismal hypertension. Childhood feochromositoma is generally genetic while it is mostly sporadic in adults. Here we report three feochromositoma cases in whom two had von Hippel Lindau syndrome (VHLs).Case 1: 10 years old girl with admitted with fever. H...

Pituitary tumors are the most frequent intracranial neoplasm, affecting 11 000 of the world wide population. However metastases in this location are rare and uncommon presentation of systemic malignancy. Although diabetes insipidus secondary to cancer metastasis to the pituitary gland is a common manifestation, anterior pituitary failure is rare. We present a −57-year-old man with hypopituitarism secondary to pituatry metastasis from lung cancer.Ca...

Thyroid cancer is the most prevalent cancer among endocrine malignancies. In clinically, surgical resection combined with radioactive iodine therapy has been proved effective in treating differentiated thyroid cancer, including papillary and follicular thyroid cancers (FTC). However, patients with incurable differentiated thyroid cancer (DTC), poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) exhibit worse prognosis. Therefore, a novel and effecti...

Objective: We longitudinally assessed the overall and age- and sex-specific incidence rates and relative risks of newly diagnosed diabetes mellitus in patients surviving the first-attack acute pancreatitis (AP) as compared to matched controls.Methods: Study cohort included 2966 AP patients and 11 864 non-AP controls individually matched on age, sex and date of index admission, with an AP/non-AP ratio of 1:4. Incidence rate was estimated under Poisson ass...

Thyroid cancer is the most prevalent cancer among endocrine malignancies. Surgical resection combined with radioactive iodine therapy has been proved effective in treating differentiated thyroid cancer, including papillary and follicular thyroid cancers (FTC). However, patients with incurable differentiated thyroid cancer (DTC), poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) exhibit worse prognosis. Therefore, a novel and effective treatment is...

Introduction: Cushing’s disease (CD) is a potentially fatal disease caused by corticotrophic adenoma of the pituitary gland. Crooke Cell Adenomas (CCA) are a rare variant characterized by cytoplasmic ring deposits of cytokeratin filaments. They are usually aggressive macroadenomas with a higher rate of recurrence and malignancy.Clinical case: A 36 year old man, with 34 kg weight gain and uncontrolled hypertension for 4 years presented at the Emerge...

Multiple endocrine neoplasia type 1 (MEN1) is an inherited tumour syndrome characterized by the development of tumours of the parathyroid, anterior pituitary and pancreatic islets, etc. Heterozygous germ line mutations of MEN1 gene are responsible for the onset of MEN1. Here We reported totally 87 patients from 24 unrelated Chinese families associated with MEN1 and identified five novel mutations and several previously reported mutations. Furthermore, we detected a loss of het...