Endocrine Abstracts

The type 3 deiodinase enzyme (D3) inactivates T3 and prevents activation of T4 to protect the fetus from premature exposure to thyroid hormones. Rapidly falling levels of D3 activity and rising levels of T3 at birth initiate the onset of cell differentiation and organ maturation during the post-natal period. Congenital hypothyroidism causes delayed ossification with reduced bone mineral deposition and short stature. We hypothesize that increase...

Hypercalcemic complications of PHPT include renal, cardiovascular, gastrointestinal, neuromuscular and neuropsychiatric issues, all potentially impacting negatively on HRQOL. As control of the hypercalcemia associated with PHPT might improve HRQOL, the SF-36 and a 6-item scale on cognitive functioning (CF) were included in a phase 2, single-arm study evaluating the ability of cinacalcet to control serum calcium levels in 17 patients with intractable PHPT. Mean±S.E....

While primary hyperparathyroidism is most commonly due to a parathyroid adenoma, very occasionally it may be secondary to a parathyroid carcinoma. A substantial minority of parathyroid adenomas are due to mutations or transpositions in genes in involved in the regulation of the cell cycle. In particular, at the cell cycle checkpoint which regulates exit from G1 phase, there is an interaction between the cyclins and cyclin-dependent kinases (CDKs); specifically, cyclin D intera...

IntroductionThe Sodium Iodide Symporter (NIS) is responsible for the active transport of iodide into thyroid cells. Most of differentiated thyroid carcinomas (TC) retain the functional expression of NIS, which allows the use of radioiodide (RAI) as the systemic treatment of choice for metastatic disease. Still, a significant proportion of patients with advanced thyroid cancer fail to respond to RAI therapy (refractory-TC), which makes their management ve...

BackgroundAutosomal dominant hypocalcaemia, caused by either inherited or de novo mutations in calcium-sensing receptor gene (CASR), is biochemically characterized by the presence of hypocalcaemia, hypercalciuria and inappropriately low levels of PTH. Receptor-activating mutations induce an increase sensitivity to calcium by parathyroid and renal cells, leading to suppression of PTH synthesis and consequently hypocalcaemia. Clinical manifestations are va...

IntroductionExenatide may provide weight loss in type 2 diabetes mellitus (T2D) via agonistic effect on GLP1 receptor. There is no study showing associations between free T4(fT4) and exenatide-related weight loss in T2D. We aimed to reveal the association between fT4 and exenatide-related weight loss, and change in thyroid functions with exenatide in euthyroid adult patients with T2D and obesity.Materials and Methods<p class="a...

IntroductionPrevious studies in women with idiopathic infertility have shown that obesity does not independently contribute to the decrease in the success of assisted reproductive technology (ART) techniques. However, few studies evaluated the success rate of ART between obese and non-obese women in infertility associated with PCOS.ObjectiveTo compare the number of oocytes, mature oocytes, number of embryos a...

Introduction: Diagnostic markers to detect Diabetic Kidney Disease (DKD) at an early stage are important. Neutrophil to Lymphocyte ratio (NLR) is an easily available parameter to assess the inflammatory status of the subject and has shown its usefulness in prognostication of Cardiovascular diseases and Malignancy. Very few studies have explored the association between NLR and DKD in the North-Eastern Indian population with type 2 diabetes mellitus.Object...

Introduction: Myxedema coma is very rare and its mortality is quite high. It is even rarer to occur due to an immune checkpoint inhibitor.Case: A 69-year-old patient presented with complaints of dyspnea, fatigue, edema, and hypotension. He had diabetes mellitus, hypertension, and metastatic lung cancer diagnosis. Three weeks ago, he had taken the 10th cycle of atezolizumab for lung cancer, which he had been taking for 7 months. The patient’s body te...

Introduction: Addison Disease is a rare condition with an estimated incidence in the developed world of 0.8 cases per 100 000 population. It is associated with relevant morbidity and mortality rates, but once the diagnosis is made it can be easily managed. When Addison Disease is associated with other autoimmune diseases, the diagnosis of polyglandular autoimmune syndrome can be set. The recognition of symptoms and signs can be challenging and clinicians should be aware of aty...