Endocrine Abstracts

Objective: Matrix γ-carboxyglutamate (Gla) protein (MGP) is a marker of athero-sclerosis reflecting the degree of inhibition of ongoing calcification processes in the vascular wall. Osteoprotegerin (OPG) and adiponectin (ADP) exerts anti-inflammatory and anti-atherosclerotic effects. We aimed at determining in type 2 diabetes patients the relationship between serum MGP, OPG, ADP levels and the HbA1c, HOMA insulin-sensitivity or B-cell function.Resea...

Disruption of the normal cell cycle is one of the most frequent alterations in tumour cells, contributing to uncontrolled cell proliferation during tumour development. The CDK inhibitor p27 plays a pivotal role in controlling cell proliferation during development and tumourigenesis, and has been implicated in tumorigenesis in rats. Previous studies have demonstrated changes in p27 protein expression, in human pituitary tumours,especially in corticotroph tumours, where p27 prot...

Background: Pregnancy with type 1 diabetes mellitus (T1DM) carries risks for many adverse outcomes; the most common are large-for-gestational-age neonates (LGA). Proper glycemic control reduces the risk for LGA. However, it occurs in almost 40% of T1DM pregnancies despite of achieving almost normoglycemia. Some studies suggested the contributing role of maternal body mass index (BMI) and glucovariability, but the effect on development of LGA still remains unclear.<p class=...

Introduction: In 2009 the Endocrine Society’s clinical practice guidelines for management of hypoglycemic disorders, confirming previous suggestions, have stated that the new cut-off of insulin for the diagnosis of insulinoma should be lowed to 3 μU/mL in presence of hypoglycemia (serum glucose ≤55 mg/dL). Moreover hypoglycemia in post-prandial status has been reported in insulinoma, alone or associated with fasting hypoglycemia. Finally preexisting diabetes me...

Aim of the study: Presenting the changes in surgical management and patients’ characteristics based on a single-center data.Material and method: From 29/10/1997 to 31/04/2011 824 adrenalectomies were carried out, 641 (78%) laparoroscopic and 183 (22%) open. In all cases of laparoscopic adrenalectomy (LA) lateral transabdominal approach was used. Bilateral simultaneous adrenalectomy with the changing patient position was performed for bilateral pheoc...

Androgens are one of the most important agents influencing folliculogenesis. They can modulate follicular function by interactions with various factors and promote granulosa cells differentiation. On the other hand, androgens can antagonize follicular development by inducing apoptosis in granulosa cells. Therefore, androgens can promote follicular atresia. The purpose of the present study was to test the hypothesis that androgen receptor antagonists (2-hydroxyflutamide (2-Hf) ...

All evidence so far indicates a role of different connexins during gonadal development, gamete formation and testicular and ovarian functions. Connexin 43 (Cx43) is one of the predominant gap junction proteins in the testis and ovary. It is well established that gonads development is highly sensitive to hormonal disruption induced by various endocrine active compounds during fetal period. Therefore, it was interesting to study whether communication via gap junctions is altered...

Introduction: It is believed that key pathogenic mechanism of PCOS is hyperinsulinemia. Insulin synthesis is linked to C-peptide release, but the role of C-peptide in PCOS remains unknown.Methods: The aim of this study was to evaluate of C-peptide serum levels in obese women with PCOS with concomitant assessment of possible link between C-peptide concentrations and metabolic disturbances and androgens levels in those individuals.Si...

Patients with non-functional FOXE1 (forkhead transcription factor) display congenital hypothyroidism, ‘spikey’ hair and other abnormalities. In the thyroid, FoxE1 controls migration of the developing gland and adult expression of thyroid specific genes. Our earlier studies demonstrated FOXE1 protein expression in keratinocytes of the epidermis and hair-follicle outer root sheath.We aimed to characterise the expression and functional activity of...

In addition to its central role in the control of thyrocyte growth and function, the TSHR is expressed during the differentiation of mesenchymal precursors. To explore further, we have developed an in vitro model in which TSHR activation is achieved by introducing constitutively active (M453T, L629F) TSHR, using retroviral vectors.We aimed to investigate the effect of TSHR activation on body composition, via the production of TNFα and express...